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Last Posted: Sep 27, 2022
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Genetic risk factors have a substantial impact on healthy life years
S Jukarainen et al, Nature Medicine, September 12, 2022

The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genetic information from 735,748 individuals and consider 80 diseases. Rare variants had the highest effect on DALYs at the individual level.

Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.
Li Xiangwei et al. Nature communications 2022 9 (1) 5269

DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci.

Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women
P Jain et al, JAMA Network Open, July 27, 2022

This cohort study was a secondary analysis of 3 Women’s Health Initiative ancillary studies among 1813 women eligible to survive to age 90 years by end of study period. The study found that increased epigenetic age acceleration as measured by 4 epigenetic clocks was associated with lower odds of survival to age 90 years with intact mobility; results were similar when including intact cognitive functioning. Meaning These findings suggest that epigenetic age acceleration may be a useful biomarker to estimate functional and cognitive aging among older women.

Age estimation from sleep studies using deep learning predicts life expectancy
AB Kjaer et al, NPJ Digital Medicine, July 21, 2022

After controlling for demographics, sleep, and health covariates, each 10-year increment in age estimate error (AEE) was associated with increased all-cause mortality rate of 29% (95% confidence interval: 20–39%). An increase from -10 to +10?years in AEE translates to an estimated decreased life expectancy of 8.7?years (95% confidence interval: 6.1–11.4?years). Greater AEE was mostly reflected in increased sleep fragmentation, suggesting this is an important biomarker of future health independent of sleep apnea.


Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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