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Hot Topics of the Day|PHGKB
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03/06/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

We’re learning a lot about the coronavirus. It will help us assess risk
H Branswell, Stat News, March 6, 2020

There are still many, many questions about this virus and the disease it causes, Covid-19. But in a matter of mere weeks, a number of features of the disease have come into focus, through extraordinarily rapid sharing of research.

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
M Hoffman et al, Cell, March 5, 2020

SARS-CoV-2 uses the SARS-CoV receptor ACE2 for host cell entry The spike protein of SARS-CoV-2 is primed by TMPRSS2 Antibodies against SARS-CoV spike may offer some protection against SARS-CoV-

Coronavirus Disease 2019 (COVID-19)-Updates on COVID-19 diagnosis and treatment
JAMA Network, 2020

Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients
T Fehlmann et al, JAMA Oncology, March 5, 2020

This cohort study used genome-wide microRNA profiles from the blood samples of 3046 individuals to identify patients with lung cancer with 91.4% accuracy, 82.8% sensitivity, and 93.5% specificity. Meaning The findings of this study suggest that circulating microRNAs may be used in a liquid biopsy to complement imaging tests, sputum cytology, and biopsies

New next-generation sequencing technique dramatically shortens diagnosis of sepsis
Eureka Alert, March 4, 2020

A new technique that uses real-time next-generation sequencing (NGS) to analyze tiny amounts of microbial cell-free DNA in the plasma of patients with sepsis, offering the possibility of accurate diagnosis of sepsis-causing agents within a few hours of drawing blood. Current diagnostic tests are neither fast nor specific.

Risk stratification of prostate cancer through quantitative assessment of PTEN loss (qPTEN)
JNCI, March 2020

Compared to previous qualitative approaches, qPTEN improves risk stratification of post-radical prostatectomy patients and may be considered as a complementary tool to guide disease management after surgery.

Using human genetics to guide the repurposing of medicines.
Bovijn Jonas et al. International journal of epidemiology 2020 Feb

Mendelian randomization has unraveled new insights into causal mechanisms of disease. While elucidation of etiological role of risk factors and biomarkers in disease is of clinical and public health importance, it is also valuable to know whether particular pharmacological targets, typically proteins, are of therapeutic relevance in specific diseases.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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