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Hot Topics of the Day|PHGKB
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02/13/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Smoking Cessation: A Report of the Surgeon General
CDC, February 2020 Brand

This report makes it clear that one of the most important actions people can take to improve their health is to quit smoking. This is true regardless of their age or how long they’ve been smoking. We know more about the science of quitting than ever before, including the role of genetic and biological factors. The report serves as a call to action to our nation.

Opportunities and Challenges for Polygenic Risk Scores in Prognostication and Prevention of Cardiovascular Disease
CJ O'Donnell, JAMA Cardiology, February 12, 2020

Many unresolved issues: Which PRS algorithms should be used in risk assessment and ultimately in treatment decisions? What are appropriate PRS thresholds for elevated risk? How does PRS modify monogenic risk? What are the appropriate PRS risk algorithms in multiethnic populations, including African American and Hispanic American groups?

Association of Monogenic vs Polygenic Hypercholesterolemia With Risk of Atherosclerotic Cardiovascular Disease
M Trinder et al, JAMA Cardiology, February 11, 2020

In this cohort study of 48?741 adults recruited by the UK Biobank, individuals with comparable levels of low-density lipoprotein cholesterol, monogenic hypercholesterolemia were found to have a greater risk of CVD compared to those with polygenic hypercholesterolemia.

Global Call to Action on Familial Hypercholesterolemia
YouTube Video, February 10, 2020

How do we prioritize FH as a public health concern? The Global Call to Action on FH was authored by a global panel of scientific experts, advocacy leaders, public health officials, and individuals with familial hypercholesterolemia (FH) from 40 countries. The report notes glaring gaps in screening and guideline-based care for FH.

Major Strides in HER2 Blockade for Metastatic Breast Cancer
P Sharma, NEJM, February 12, 2020

In summary, the HER2CLIMB and DESTINY-Breast01 trials represent major advances in the treatment of HER2-positive metastatic breast cancer and mark the beginning of the next frontier of highly effective HER2-targeted agents.

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
S Modi et al, NEJM, February 12, 2020

Trastuzumab deruxtecan showed durable antitumor activity in a pretreated patient population with HER2-positive metastatic breast cancer. In addition to nausea and myelosuppression, interstitial lung disease was observed in a subgroup of patients and requires attention to pulmonary symptoms and careful monitoring.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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