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Hot Topics of the Day|PHGKB
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02/07/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Genetics of Congenital Heart Disease.
Williams Kylia et al. Biomolecules 2019 Dec (12)

The genetic workup for structural congenital heart disease.
Jerves Teodoro et al. American journal of medical genetics. Part C, Seminars in medical genetics 2019 Dec

Genetic Contribution to Congenital Heart Disease (CHD).
Shabana N A et al. Pediatric cardiology 2020 Jan (1) 12-23

The elucidation of genetic components remains difficult because it is a genetically heterogeneous disease. Currently, the major identified genetic causes include chromosomal abnormalities, large subchromosomal deletions/duplications, and point mutations. However, much more remains to be unraveled.

The application of big data to cardiovascular disease: paths to precision medicine.
Leopold Jane A et al. The Journal of clinical investigation 2020 Jan (1) 29-38

Association of Germline Genetic Testing Results With Locoregional and Systemic Therapy in Patients With Breast Cancer
AW Kurian et al, JAMA Oncology, February 6, 2020

In a population-based study, women with germline pathogenic variants in BRCA and other breast cancer susceptibility genes have been found to have different patterns of breast cancer treatment, which may be less concordant with practice guidelines, particularly for radiotherapy and chemotherapy.

Shipping of CDC 2019 Novel Coronavirus Diagnostic Test Kits Begins
CDC, February 6, 2020 Brand

A CDC-developed laboratory test kit to detect 2019 novel coronavirus (2019-nCoV) began shipping yesterday to select qualified U.S. and international laboratories. Distribution of the tests will help improve the global capacity to detect and respond to the 2019 novel coronavirus.

From computer to clinic: The challenges of implementing artificial intelligence in practice
Stat News Webinar, February 13, 2020

It’s one thing to train an algorithm to produce headline-grabbing results on paper. It’s quite another to train it to improve care for patients in practice. We will explore the challenges health systems must address to close that crucial gap in the field of artificial intelligence, where the science of validating algorithms is still a work in progress.

CRISPR takes on cancer
J Couzin-Frankel, Science, February 7, 2020

Launching a new chapter in the fast-moving cancer immunotherapy field, scientists have blended two cutting-edge approaches: CRISPR, which edits DNA, and T cell therapy, in which sentries of the immune system are exploited to destroy tumors.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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