Neighborhood Deprivation Measures and DNA Methylation Clocks-Understanding the Real Needs of Each Person.
Benjamin D Horne et al. JAMA Netw Open 2023 11 (11) e2344688 (Posted Dec 02, 2023 9AM)
From the article: " A recent study reports a unique and powerful approach for finding neighborhood factors marking risks of early death and disease.4 Measurement of racial segregation using spatial clustering methods and separating that from economic deprivation (and education) aid in clarifying the sources of health concerns. The study uses methylation patterns which can be remodeled by many factors such as smoking, physical activity, diet, infection, and stressors from the childhood environment (eg, lack of loving adult support, malnutrition), adverse living conditions (eg, noise pollution, particulate matter air pollution), and poor interactions with others (eg, emotional or physical abuse). "
Latina immigrants' breast and colon cancer causal attributions: genetics is key.
Katie Fiallos et al. J Community Genet 2023 11 (Posted Dec 01, 2023 7AM)
From the abstract: "Participants answered semi-structured, open-ended questions regarding the risk factors and rankings. Interviews were transcribed and subjected to thematic analysis. CCA showed no consensus around rank of causes for either cancer, and residual agreement analysis suggested the presence of two subcultural groups. “Genetics” and “hereditary factors” ranked first and second on average across participants for both cancers. Based on interview data, participants were less aware of colon cancer than breast cancer. Participants’ endorsement of heredity as a cause of breast and colon cancer was similar to beliefs reported in studies of primarily non-Latina populations. "
Down Syndrome in a New Era for Alzheimer Disease.
Michael S Rafii et al. JAMA 2023 11 (Posted Nov 29, 2023 9AM)
From the paper: "Despite the ultra-high risk for Alzheimer disease and its effect of a shortened life expectancy, persons with Down syndrome who are experiencing Alzheimer disease–related cognitive decline have limited access to expert clinical evaluation for dementia, let alone these newly approved therapeutics. At the same time, because of the genetic basis for lifelong amyloid accumulation, there are also significant concerns related to cerebral amyloid angiopathy and the risk of adverse events related to amyloid-related imaging abnormalities (ARIA). This requires careful assessment of safety and tolerability in individuals with Down syndrome to be done before these drugs can be widely prescribed in this vulnerable population. "
Public Health Genetics, Gene Therapy, and Duchenne Muscular Dystrophy
CDC Webinar, December 18, 2023 (Posted Nov 27, 2023 10AM)
From the website: "This webinar will review the population health impact of rare diseases such as DMD. Presenters will cover the genetics and clinical impact of DMD, the evolution of gene therapy, the development of FDA-approved gene therapy to treat the underlying protein deficiency that causes DMD, and the health equity challenges. "
Latest News and Publications
Enhancing the value of digital health tools for mental health help-seeking in Canadian transitional aged youth during the pandemic: Qualitative study.
Lo Brian, et al. International journal of medical informatics 2023 0 0. 105299
Characterization of COVID-19 vaccine clinical trial discussions on the social question-and-answer site Quora.
Xu Qing, et al. Trials 2023 0 0. (1) 790
Looking ahead: ethical and social challenges of somatic gene therapy for sickle cell disease in Africa.
Nchangwi Syntia Munung et al. Gene Ther 2023
The implementation and utility of clinical exome sequencing in a South African infant cohort.
L Campbell et al. Front Genet 2023 141277948
Relationships between COVID-19 healthcare outcomes and county characteristics in the U.S. for Delta (B.1.617.2) and Omicron (B.1.1.529 and BA.1.1) variants.
Bruckhaus Alexander A, et al. Frontiers in public health 2023 0 0. 1252668
Relative vaccine effectiveness of mRNA COVID-19 boosters in people aged at least 75 years during the spring-summer (monovalent vaccine) and autumn-winter (bivalent vaccine) booster campaigns: a prospective test negative case-control study, United Kingdom, 2022.
Chatzilena Anastasia, et al. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2023 0 0. (48)
Use of a digital contact tracing system in Singapore to mitigate COVID-19 spread.
Chow Bryan W K, et al. BMC public health 2023 0 0. (1) 2253
The GenoVA study: Equitable implementation of a pragmatic randomized trial of polygenic-risk scoring in primary care.
Jason L Vassy et al. Am J Hum Genet 2023 110(11) 1841-1852
Characterization of SARS-CoV-2 genetic evolution in vaccinated and non-vaccinated patients from the Kenyan population.
Oyola Samuel, et al. Research square 2023 0 0.
Call to Action for Advancing Equitable Genomic Newborn Screening.
Anne L Ersig et al. Public Health Genomics 2023
Population Pharmacogenomics for Health Equity.
I King Jordan et al. Genes (Basel) 2023 14(10)
Predicting Dental Caries Outcomes in Young Adults Using Machine Learning Approach.
Chukwuebuka Ogwo et al. Res Sq 2023
Technical/Algorithm, Stakeholder, and Society (TASS) Barriers to the Application of Artificial Intelligence in Medicine: A Systematic Review.
Linda T Li et al. J Biomed Inform 2023 104531
Detection of SARS-CoV-2 in high-efficiency particulate air (HEPA) filters of low-cost air purifiers in community-based organizations.
Rachel D Clarke et al. Environ Monit Assess 2023 10 (11) 1320
Benefits and concerns of expanded carrier screening: what do pregnant Latina women in Texas think?
Embedzayi Madhiri et al. J Community Genet 2023
A health systems assessment of genetic counseling in cardiovascular care in a large health system: Adherence to genetics recommendations in the Military Health System.
Lydia D Hellwig et al. J Genet Couns 2023
Newborn Screening for Neurodevelopmental Disorders May Exacerbate Health Disparities.
Sarah A Sobotka et al. Pediatrics 2023
The health inequality impact of liquid biopsy to inform first-line treatment of advanced non-small cell lung cancer - a distributional cost-effectiveness analysis.
Jeroen P Jansen et al. Value Health 2023
Polymorphisms within the SARS-CoV-2 Human Receptor Genes Associate with Variable Disease Outcomes across Ethnicities.
Adimulam Theolan, et al. Genes 2023 0 0. (9)
Use of whole genome sequencing to identify low-frequency mutations in SARS-CoV-2 patients treated with remdesivir.
Kuganya Nirmalarajah et al. Influenza Other Respir Viruses 2023 9 (9) e13179