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Health Equity PHGKB

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Last Posted: Dec 09, 2023
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Neighborhood Deprivation Measures and DNA Methylation Clocks-Understanding the Real Needs of Each Person.
Benjamin D Horne et al. JAMA Netw Open 2023 11 (11) e2344688 (Posted Dec 02, 2023 9AM)

From the article: " A recent study reports a unique and powerful approach for finding neighborhood factors marking risks of early death and disease.4 Measurement of racial segregation using spatial clustering methods and separating that from economic deprivation (and education) aid in clarifying the sources of health concerns. The study uses methylation patterns which can be remodeled by many factors such as smoking, physical activity, diet, infection, and stressors from the childhood environment (eg, lack of loving adult support, malnutrition), adverse living conditions (eg, noise pollution, particulate matter air pollution), and poor interactions with others (eg, emotional or physical abuse). "

Latina immigrants' breast and colon cancer causal attributions: genetics is key.
Katie Fiallos et al. J Community Genet 2023 11 (Posted Dec 01, 2023 7AM)

From the abstract: "Participants answered semi-structured, open-ended questions regarding the risk factors and rankings. Interviews were transcribed and subjected to thematic analysis. CCA showed no consensus around rank of causes for either cancer, and residual agreement analysis suggested the presence of two subcultural groups. “Genetics” and “hereditary factors” ranked first and second on average across participants for both cancers. Based on interview data, participants were less aware of colon cancer than breast cancer. Participants’ endorsement of heredity as a cause of breast and colon cancer was similar to beliefs reported in studies of primarily non-Latina populations. "

Down Syndrome in a New Era for Alzheimer Disease.
Michael S Rafii et al. JAMA 2023 11 (Posted Nov 29, 2023 9AM)

From the paper: "Despite the ultra-high risk for Alzheimer disease and its effect of a shortened life expectancy, persons with Down syndrome who are experiencing Alzheimer disease–related cognitive decline have limited access to expert clinical evaluation for dementia, let alone these newly approved therapeutics. At the same time, because of the genetic basis for lifelong amyloid accumulation, there are also significant concerns related to cerebral amyloid angiopathy and the risk of adverse events related to amyloid-related imaging abnormalities (ARIA). This requires careful assessment of safety and tolerability in individuals with Down syndrome to be done before these drugs can be widely prescribed in this vulnerable population. "

Public Health Genetics, Gene Therapy, and Duchenne Muscular Dystrophy
CDC Webinar, December 18, 2023 (Posted Nov 27, 2023 10AM)

From the website: "This webinar will review the population health impact of rare diseases such as DMD. Presenters will cover the genetics and clinical impact of DMD, the evolution of gene therapy, the development of FDA-approved gene therapy to treat the underlying protein deficiency that causes DMD, and the health equity challenges. "


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About Health Equity PHGKB

Health Equity PHGKB is an online, continuously updated, searchable database of genomics and precision health information and publications relevant to health equity...more

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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