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Health Equity PHGKB

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Last Posted: Jun 29, 2022
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Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge et al, Genome Medicine, June 29, 2022

We integrated T2D GWAS in European, African, and East Asian populations to construct a trans-ancestry T2D PRS using a newly developed Bayesian polygenic modeling method, and assessed the prediction accuracy of the PRS in the multi-ethnic Electronic Medical Records and Genomics (eMERGE) study (11,945 cases; 57,694 controls), four Black cohorts (5137 cases; 9657 controls), and the Taiwan Biobank (4570 cases; 84,996 controls). We additionally evaluated a post hoc ancestry adjustment method that can express the polygenic risk on the same scale across ancestrally diverse individuals and facilitate the clinical implementation of the PRS in prospective cohorts.

Virtual Workshop on Integrating Climate and Environmental Data and Justice into the All of Us Research Program
NIH, All of Us Research Program Workshop, July 28-29, 2022

The goal of this workshop is to discuss innovative project ideas for potential Ancillary Studies between the All of Us Research Program and the National Institute for Environmental Health Sciences. An ‘Ancillary Study’ is one that creates a new data type for All of Us by virtue of the question(s) it aims to answer. Ancillary Studies may also add new participants to the program. Workshop participants will also discuss environmental exposures or data linkages that should be considered for collection in the entire All of Us cohort.

How COVID has deepened inequality — in six stark graphics
SM Sidick, Nature, June 23, 2022

Troubling data show how the pandemic has exacted an unequal toll, pushing tens of millions into poverty and having the greatest effects on already-disadvantaged groups. The shock waves of the COVID-19 pandemic have reverberated throughout the world. But the latest data reveal that the burden of COVID and its aftermath does not rest equally. In six graphics, Nature details how the pandemic has worsened existing inequalities and exposed others in terms of income, health, safety and more.

Dispensing of Oral Antiviral Drugs for Treatment of COVID-19 by Zip Code–Level Social Vulnerability — United States, December 23, 2021–May 21, 2022
JAW Gold et al, MMWR, June 21, 2022

Lagevrio and Paxlovid are oral antiviral drugs effective at preventing hospitalization and death in patients with mild to moderate COVID-19 who are at risk for progression to severe disease. During December 23, 2021–May 21, 2022, 1,076,762 oral antiviral prescriptions were dispensed in the United States. The overall number of antivirals dispensed increased; however, by the end of the study period, dispensing rates were lowest in high vulnerability zip codes, despite these zip codes having the largest number of dispensing sites.

news Latest News and Publications
The genetic and evolutionary determinants of COVID-19 susceptibility. External Web Site Icon
Kerner Gaspard et al. European journal of human genetics : EJHG 2022 6
SARS-CoV-2 omicron: Light at the end of the long pandemic tunnel or another false dawn for immunodeficient patients? External Web Site Icon
Ameratunga Rohan, et al. The journal of allergy and clinical immunology. In practice 2022 0 0.
BNT162b2 Booster Vaccination Induced Immunity against SARS-CoV-2 Variants among Hemodialysis Patients. External Web Site Icon
Herman-Edelstein Michal, et al. Vaccines 2022 0 0. (6)
SARS-CoV-2 Mutant Spectra at Different Depth Levels Reveal an Overwhelming Abundance of Low Frequency Mutations. External Web Site Icon
Martínez-González Brenda, et al. Pathogens (Basel, Switzerland) 2022 0 0. (6)
A multi-stakeholder approach is needed to reduce the digital divide and encourage equitable access to telehealth. External Web Site Icon
Gallegos-Rejas Victor M, et al. Journal of telemedicine and telecare 2022 0 0. 1357633X221107995
Assessing the Capability of Government Information Intervention and Socioeconomic Factors of Information Sharing during the COVID-19 Pandemic: A Cross-Country Study Using Big Data Analytics. External Web Site Icon
Park Sejung, et al. Behavioral sciences (Basel, Switzerland) 2022 0 0. (6)
How COVID has deepened inequality — in six stark graphics External Web Site Icon
SM Sidick, Nature, June 23, 2022
Dispensing of Oral Antiviral Drugs for Treatment of COVID-19 by Zip Code–Level Social Vulnerability — United States, December 23, 2021–May 21, 2022
JAW Gold et al, MMWR, June 21, 2022
Quantifying Inequities in COVID-19 Vaccine Distribution Over Time by social vulnerability, race and ethnicity, and location: A Population-Level Analysis in St. Louis and Kansas City, Missouri External Web Site Icon
A Mody et al, MEDRXIV, June 16, 2022
Exploring association of mobile phone access with positive health outcomes and behaviors amongst post-partum mothers in rural Malawi. External Web Site Icon
Anto-Ocrah Martina, et al. BMC pregnancy and childbirth 2022 0 0. (1) 485
Effects of social support on depression risk during the COVID-19 pandemic: What support types and for whom? External Web Site Icon
KW Choi et al, MEDRXIV, May 16, 2022
A machine learning-driven spatio-temporal vulnerability appraisal based on socio-economic data for COVID-19 impact prevention in the U.S. counties. External Web Site Icon
Moosazadeh Mohammad, et al. Sustainable cities and society 2022 0 0. 103990
Bayesian spatial modeling of COVID-19 case-fatality rate inequalities. External Web Site Icon
Polo Gina, et al. Spatial and spatio-temporal epidemiology 2022 0 0. 100494
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR. External Web Site Icon
Schwarz Megan et al. Nature biotechnology 2022 6
COVID-19 Vaccination Coverage, by Race and Ethnicity — National Immunization Survey Adult COVID Module, United States, December 2020–November 2021
JL Kriss et al, MMWR, June 10, 2022
Longitudinal SARS-CoV-2 RNA wastewater monitoring across a range of scales correlates with total and regional COVID-19 burden in a well-defined urban population. External Web Site Icon
Acosta Nicole, et al. Water research 2022 0 0. 118611
Nasal Spray of Neutralizing Monoclonal Antibody 35B5 Confers Potential Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern (VOCs): A Small-scale Clinical Trial. External Web Site Icon
Lin Yao, et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 0 0.
COVID-19 Variant Surveillance and Social Determinants in Central Massachusetts: Development Study. External Web Site Icon
Shi Qiming, et al. JMIR formative research 2022 0 0.
A novel textual track-data-based approach for estimating individual infection risk of COVID-19. External Web Site Icon
Wei Lu, et al. Risk analysis : an official publication of the Society for Risk Analysis 2022 0 0.
Development and implementation of a simple and rapid extraction-free saliva SARS-CoV-2 RT-LAMP workflow for workplace surveillance. External Web Site Icon
Li Zhiru, et al. PloS one 2022 0 0. (5) e0268692


Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.