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Health Equity PHGKB

Specific PHGKB|Health Equity PHGKB|Public Health Genomics and Precision Health Knowledge Base (PHGKB)

Last Posted: Jun 06, 2024
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Family communication of cancer genetic test results in an ethnically diverse population: a qualitative exploration of more than 200 patients
(Posted Jun 06, 2024 2PM)

From the abstract: " Previous research on family communication of cancer genetic test results has primarily focused on non-Hispanic White patients with high-risk pathogenic variants (PV). There are limited data on patient communication of moderate-risk PVs, variants of uncertain significance (VUS), and negative results. This qualitative study examined communication of positive, negative, and VUS hereditary cancer multi-gene panel (MGP) results in an ethnically and socioeconomically diverse population. "

Sustaining Community Engagement in Genomics Research: A Workshop
(Posted May 30, 2024 0PM)

From the website: "This hybrid workshop will examine how researchers could more meaningfully engage and sustain interactions with historically underrepresented communities in research to foster their participation in genomics and precision health studies. The overarching goal of the workshop is to help improve the quality of genomics research by understanding where obstacles to sustained community involvement remain. "

The acceptability and clinical impact of using polygenic scores for risk-estimation of common cancers in primary care: a systematic review
(Posted May 24, 2024 9AM)

From the abstract: "A total of 190 papers were identified, 18 of which were eligible for inclusion. A cancer risk-assessment tool incorporating PGS was acceptable to the general practice population and their healthcare providers but major challenges to implementation were identified, including lack of evidence for PGS in non-European ancestry and a need for healthcare provider education in genomic medicine. A PGS cancer risk-assessment had relatively limited impact on psychosocial outcomes and health behaviours. However, for prostate cancer, potential applications for its use in primary care were shown. "

Generalization—a key challenge for responsible AI in patient-facing clinical applications
(Posted May 22, 2024 2PM)

From the abstract: "Generalization – the ability of AI systems to apply and/or extrapolate their knowledge to new data which might differ from the original training data – is a major challenge for the effective and responsible implementation of human-centric AI applications. Current debate in bioethics proposes selective prediction as a solution. Here we explore data-based reasons for generalization challenges and look at how selective predictions might be implemented technically, focusing on clinical AI applications in real-world healthcare settings. "

news Latest News and Publications
Results from the Delivery of a Community Health Worker Training to Advance Competencies in Cancer Genomics. External Web Site Icon
Caitlin G Allen et al. Public Health Genomics 2024
Artificial Intelligence in the Provision of Health Care: An American College of Physicians Policy Position Paper. External Web Site Icon
Nadia Daneshvar et al. Ann Intern Med 2024
Equity and AI governance at academic medical centers. External Web Site Icon
Paige Nong et al. Am J Manag Care 2024 30(6 Spec No.) SP468-SP472
The impact of health inequity on spatial variation of COVID-19 transmission in England. External Web Site Icon
Rawson Thomas, et al. PLoS computational biology 2024 0 0. (5) e1012141
Severity of Omicron Subvariants and Vaccine Impact in Catalonia, Spain. External Web Site Icon
de Rioja Víctor López, et al. Vaccines 2024 0 0. (5)
Cascade genetic testing: an underutilized pathway to equitable cancer care? External Web Site Icon
Roni Nitecki Wilke et al. Fam Cancer 2024
Increased prevalence of the COVID-19 associated Neanderthal mutations in the Central European Roma population. External Web Site Icon
Hubácek Jaroslav A, et al. Annals of human biology 2024 0 0. (1) 2341727
Environmental Surveillance of Flood Control Infrastructure Impacted by Unsheltered Individuals Leads to the Detection of SARS-CoV-2 and Novel Mutations in the Spike Gene. External Web Site Icon
Anthony Harrington et al. Environ Sci Technol Lett 2024 5 (5) 410-417
Promoting Artificial Intelligence for Global Breast Cancer Risk Prediction and Screening in Adult Women: A Scoping Review. External Web Site Icon
Lea Sacca et al. J Clin Med 2024 13(9)
Implementation of AZD7442 (Tixagevimab/Cilgavimab) COVID-19 Pre-exposure Prophylaxis (PrEP) in the Largest Health Maintenance Organization in Israel: Real-world Uptake and Sociodemographic and Clinical Characteristics Across Immunocompromised Patient Groups. External Web Site Icon
Hayek Samah, et al. Infectious diseases and therapy 2024 0 0.
Advancing genomics to improve health equity. External Web Site Icon
Ebony B Madden et al. Nat Genet 2024
Artificial Intelligence (AI) for Early Diagnosis of Retinal Diseases. External Web Site Icon
Uday Pratap Singh Parmar et al. Medicina (Kaunas) 2024 60(4)
Inherent Bias in Electronic Health Records: A Scoping Review of Sources of Bias. External Web Site Icon
Oriel Perets et al. medRxiv 2024
Insights from Explainable Artificial Intelligence of Pollution and Socioeconomic Influences for Respiratory Cancer Mortality in Italy. External Web Site Icon
Donato Romano et al. J Pers Med 2024 14(4)
HLA-B and C Expression Contributes to COVID-19 Disease Severity within a South African Cohort. External Web Site Icon
Naidoo Lisa, et al. Genes 2024 0 0. (4)
Enhanced identification of familial hypercholesterolemia using central laboratory algorithms. External Web Site Icon
Shirin Ibrahim et al. Atherosclerosis 2024 393117548
Navigating equity in global access to genome therapy expanding access to potentially transformative therapies and benefiting those in need requires global policy changes. External Web Site Icon
Tsung-Ling Lee et al. Front Genet 2024 151381172
Translational Research and Health Equity: Gene Therapies for Sickle Cell Disease as a Case Study. External Web Site Icon
Mary A Majumder et al. Ethics Hum Res 2024 46(3) 34-39
Harnessing Artificial Intelligence to Address Oral Health Disparities. External Web Site Icon
Hawazin W Elani et al. JAMA Health Forum 2024 5(4) e240642
Impact of Race, Socioeconomic Status, and Geography on Healthcare Outcomes for Children With Sickle Cell Disease in the United States: A Scoping Review. External Web Site Icon
Sameerah Wahab et al. Cureus 2024 16(3) e56089


Disclaimer: Articles listed in the Public Health Knowledge Base are selected by Public Health Genomics Branch to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.