Digital twins for predictive oncology will be a paradigm shift for precision cancer care
TH Boussard et al, Nature Medicine, November 2, 2021
Cancer patient digital twins (CPDTs) use emerging computing and biotechnologies to build in silico individual representations that dynamically reflect molecular, physiological and lifestyle status across different treatments and time. We propose a CPDT framework with a continuous life cycle for shared decision-making.
Geometric network analysis provides prognostic information in patients with high grade serous carcinoma of the ovary treated with immune checkpoint inhibitors
R Elkin et al, NPJ Genomic Medicine, November 24, 2021
Network analysis methods can potentially quantify cancer aberrations in gene networks without introducing fitted parameters or variable selection. A new network curvature-based method is introduced to provide an integrated measure of variability within cancer gene networks. The method is applied to high-grade serous ovarian cancers (HGSOCs) to predict response to immune checkpoint inhibitors (ICIs) and to rank key genes associated with prognosis.
Readiness for mammography and artificial intelligence
CD Lehman et al, The Lancet, November 20, 2021
One area that has attracted great attention for the use of deep learning artificial intelligence (AI) in health care is medical imaging, especially mammography. Many initial AI studies proclaimed remarkable improvement in accuracy over the performance of radiologists, but a recent systematic review highlighted there is insufficient scientific evidence to support such findings.
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data
AA Connor et al, Nat Rev Cancer, November 17, 2021
Decades of research have improved our understanding of pancreatic cancer, including characterizing germline predisposition, the cell of origin, precursor lesions, the sequence of genetic alterations, including simple and structural alterations, transcriptional changes and subtypes, tumor heterogeneity, metastatic progression and the tumor microenvironment. These fundamental advances inform contemporary translational efforts in primary prevention, screening and early detection, multidisciplinary management and survivorship, as prospective clinical trials begin to adopt molecular-based selection criteria to guide targeted therapies.
News and Publications
Cancer incidence, patterns, and genotype-phenotype associations in individuals with pathogenic or likely pathogenic germline TP53 variants: an observational cohort study.
de Andrade Kelvin César et al. The Lancet. Oncology 2021
Chemoprevention Considerations in Patients with Hereditary Colorectal Cancer Syndromes.
Macaron Carole et al. Gastrointestinal endoscopy clinics of North America 2021 32(1) 131-146
Clinical Outcomes for Plasma-Based Comprehensive Genomic Profiling Versus Standard-of-Care Tissue Testing in Advanced Non-Small Cell Lung Cancer.
Page Ray D et al. Clinical lung cancer 2021
Comparison of risk assessment in 1652 early ER positive, HER2 negative breast cancer in a real-world data set: classical pathological parameters vs. 12-gene molecular assay (EndoPredict).
Jank Paul et al. Breast cancer research and treatment 2021
Dynamic recurrence risk and adjuvant chemotherapy benefit prediction by ctDNA in resected NSCLC.
Qiu Bin et al. Nature communications 2021 12(1) 6770
Genome-wide identification and characterization of circular RNA mA modification in pancreatic cancer.
Ye Ying et al. Genome medicine 2021 13(1) 183
Germline cancer susceptibility gene testing in unselected patients with hepatobiliary cancers: A multi-center prospective study.
Uson Junior Pedro Ls et al. Cancer prevention research (Philadelphia, Pa.) 2021
Lynch Syndrome-Associated Cancers Beyond Colorectal Cancer.
Biller Leah H et al. Gastrointestinal endoscopy clinics of North America 2021 32(1) 75-93
Parental age and retinoblastoma-a retrospective study of demographic data and genetic analysis.
Tanwar Meghana et al. Eye (London, England) 2021
Prediction model based on 18F-FDG PET/CT radiomic features and clinical factors of EGFR mutations in lung adenocarcinoma.
Zhao Hong-Yue et al. Neoplasma 2021
Predictors of Population Awareness of Cancer Genetic Tests: Implications for Enhancing Equity in Engaging in Cancer Prevention and Precision Medicine.
Giri Veda N et al. JCO precision oncology 2021 5
Prevalence of pouchitis in both Ulcerative Colitis and Familial Adenomatous Polyposis: a systematic review and meta-analysis.
Sriranganathan Danujan et al. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2021
Swiss cost-effectiveness analysis of universal screening for Lynch syndrome of patients with colorectal cancer followed by cascade genetic testing of relatives.
Salikhanov Islam et al. Journal of medical genetics 2021
Telephone versus in-person genetic counseling for hereditary cancer risk: Patient predictors of differential outcomes.
Binion Savannah et al. Journal of telemedicine and telecare 2021 1357633X211052220
Breast-conserving therapy for breast cancer with BRCA mutations: a meta-analysis.
Wang Changjun et al. Breast cancer (Tokyo, Japan) 2021
Central Nervous System Tumor Classification: An Update on the Integration of Tumor Genetics.
McLendon Roger E et al. Hematology/oncology clinics of North America 2021
Clinical and pathological analysis of companion diagnostic testing of microsatellite instability-high for pembrolizumab in gynaecologic malignancy.
Takeda Takashi et al. Japanese journal of clinical oncology 2021
Clinical Value of NGS Genomic Studies for Clinical Management of Pediatric and Young Adult Bone Sarcomas.
Gutiérrez-Jimeno Miriam et al. Cancers 2021 13(21)
Concordance of BRCA mutation detection in tumor versus blood, and frequency of bi-allelic loss of BRCA in tumors from patients in the phase III SOLO2 trial.
Hodgson Darren R et al. Gynecologic oncology 2021
Constructing germline research cohorts from the discarded reads of clinical tumor sequences.
Gusev Alexander et al. Genome medicine 2021 13(1) 179
Germline Predisposition to Pediatric Cancer, from Next Generation Sequencing to Medical Care.
Gargallo Pablo et al. Cancers 2021 13(21)
Hereditary cancer panel testing challenges and solutions for the latinx community: costs, access, and variants.
Douglas Michael P et al. Journal of community genetics 2021
Integrating NGS-derived mutational profiling in the diagnosis of multiple lung adenocarcinomas.
Ezer Nicole et al. Cancer treatment and research communications 2021 29100484
Patient-Reported Factors Associated With Older Adults' Cancer Screening Decision-making: A Systematic Review.
Smith Jenna et al. JAMA network open 2021 4(11) e2133406
Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer.
Obón-Santacana Mireia et al. BMC medicine 2021 19(1) 261
Prospective molecular classification of endometrial carcinomas: institutional implementation, practice, and clinical experience.
Devereaux Kelly A et al. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2021
Racial and Ethnic Disparities Among Participants in Precision Oncology Clinical Studies.
Aldrighetti Christopher M et al. JAMA network open 2021 4(11) e2133205
The CIRCULATE Trial: Circulating Tumor DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II Evaluation (AIO-KRK-0217).
Folprecht Gunnar et al. Clinical colorectal cancer 2021
The prevalence of tumour markers in malignant pleural effusions associated with primary pulmonary adenocarcinoma: a retrospective study.
Fjaellegaard Katrine et al. European clinical respiratory journal 2021 8(1) 1984375
TP53 Combined Phenotype Score Is Associated with the Clinical Outcome of TP53-Mutated Myelodysplastic Syndromes.
Yabe Mariko et al. Cancers 2021 13(21)