Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content
Cancer PHGKB

Specific PHGKB|Cancer|PHGKB
Last Posted: Oct 21, 2021
spot light Spotlight

Genetic Counseling and Testing in African American Patients With Breast Cancer: A Nationwide Survey of US Breast Oncologists.
Ademuyiwa Foluso O et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2021 10 JCO2101426

We demonstrated that racial differences exist in oncology physicians' perceived barriers to GCT for patients with breast cancer. This nationwide survey will serve as a basis for understanding physicians' determinants of GCT for African American women and highlights the necessity of education and interventions to address bias among physicians. Awareness of such physician biases can enable further work to address inequities, ultimately leading to improved GCT equity for African American women with breast cancer.

Tumour burden and efficacy of immune-checkpoint inhibitors.
Dall'Olio Filippo G et al. Nature reviews. Clinical oncology 2021 10

In this Review, we summarize evidence supporting the utility of tumour burden as a biomarker to guide the use of immune-checkpoint inhibitors. We also describe data and provide perspective on the various tools used for tumour burden assessment, with a particular emphasis on future therapeutic strategies that might address the issue of inferior outcomes among patients with cancer with a high tumour burden.

ctDNA: An emerging neoadjuvant biomarker in resectable solid tumors.
Abbosh Christopher et al. PLoS medicine 2021 10 (10) e1003771

Findings from recent studies add to an emerging literature highlighting a need to explore the translational potential for ctDNA assessment as a response biomarker in the neoadjuvant setting. These data are particularly relevant in LARC and MIBC where treatment response biomarkers that are not reliant on pathological examination of resection specimens are required to guide non-operative management decisions.

Single-cell RNA sequencing for the identification of early-stage lung cancer biomarkers from circulating blood
J Kim et al, NPJ Genomic Medicine, October 15, 2021

We performed single-cell RNA-sequencing (scRNA-seq) analysis using Fluidigm C1 systems to characterize human lung cancer transcriptomes at single-cell resolution. Validation of scRNA-seq differentially expressed genes (DEGs) through quantitative real time-polymerase chain reaction found a positive correlation in fold-change values between C-X-C motif chemokine ligand 1 (CXCL1) and 2 (CXCL2) compared with bulk-cell level in 34 primary lung adenocarcinomas (LUADs) from Stage I patients. Furthermore, we discovered an inverse correlation between chemokine mRNAs, miR-532-5p, and miR-1266-3p in early-stage primary LUADs. Specially, miR-532-5p was quantifiable in plasma from the corresponding LUADs. Collectively, we identified markers of early-stage lung cancer that were validated in primary lung tumors and circulating blood.

news Latest News and Publications
A four-gene prognostic signature for predicting the overall survival of patients with lung adenocarcinoma. External Web Site Icon
Liu Lei et al. PeerJ 2021 9e11911
Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing. External Web Site Icon
Shin Saeam et al. Annals of laboratory medicine 2021 42(2) 141-149
Communication processes about predictive genetic testing within high-risk breast cancer families: a two-phase study design. External Web Site Icon
Blomen Chiara L et al. Scientific reports 2021 11(1) 20178
Comparison of the Metastasis Predictive Potential of mRNA and Long Non-Coding RNA Profiling in Systemically Untreated Breast Cancer. External Web Site Icon
Do Thi T N et al. Cancers 2021 13(19)
Comprehensive Analysis of mC RNA Methylation Regulator Genes in Clear Cell Renal Cell Carcinoma. External Web Site Icon
Wu Jiajin et al. International journal of genomics 2021 20213803724
Data on Utility in Cost-Utility Analyses of Genetic Screen-and-Treat Strategies for Breast and Ovarian Cancer. External Web Site Icon
Simões Corrêa Galendi Julia et al. Cancers 2021 13(19)
Genomic Biomarkers of Meningioma: A Focused Review. External Web Site Icon
Pawloski Jacob A et al. International journal of molecular sciences 2021 22(19)
IMProving care After inherited Cancer Testing (IMPACT) study: protocol of a randomized trial evaluating the efficacy of two interventions designed to improve cancer risk management and family communication of genetic test results. External Web Site Icon
Cragun Deborah et al. BMC cancer 2021 21(1) 1099
Integrative Predictive Modeling of Metastasis in Melanoma Cancer Based on MicroRNA, mRNA, and DNA Methylation Data. External Web Site Icon
Kutlay Aysegül et al. Frontiers in molecular biosciences 2021 8637355
Is radiomic MRI a feasible alternative to OncotypeDX® recurrence score testing? A systematic review and meta-analysis. External Web Site Icon
Davey M G et al. BJS open 2021 5(5)
Medical guidelines for Li-Fraumeni syndrome 2019, version 1.1. External Web Site Icon
Kumamoto Tadashi et al. International journal of clinical oncology 2021
Patients' Expectations of Benefits From Large-Panel Genomic Tumor Testing in Rural Community Oncology Practices. External Web Site Icon
Anderson Eric C et al. JCO precision oncology 2021 5
Preexisting TP53-Variant Clonal Hematopoiesis and Risk of Secondary Myeloid Neoplasms in Patients With High-grade Ovarian Cancer Treated With Rucaparib. External Web Site Icon
Kwan Tanya T et al. JAMA oncology 2021
Factors Influencing Patient Preferences for Telehealth Cancer Genetic Counseling During the COVID-19 Pandemic. External Web Site Icon
Breen Kelsey E, et al. JCO oncology practice 2021 0 0. OP2100301
A Machine Learning Approach to the Classification of Acute Leukemias and Distinction From Nonneoplastic Cytopenias Using Flow Cytometry Data. External Web Site Icon
Monaghan Sara A et al. American journal of clinical pathology 2021
Artificial Intelligence Applications in Pediatric Brain Tumor Imaging: A Systematic Review. External Web Site Icon
Huang Jonathan et al. World neurosurgery 2021
Deep Mining Generation of Lung Cancer Malignancy Models from Chest X-ray Images. External Web Site Icon
Horry Michael et al. Sensors (Basel, Switzerland) 2021 21(19)
Detection of Metastatic Tumor Cells in the Bone Marrow Aspirate Smears by Artificial Intelligence (AI)-Based Morphogo System. External Web Site Icon
Chen Pu et al. Frontiers in oncology 2021 11742395
The Crohn's-like lymphoid reaction density: a new artificial intelligence quantified prognostic immune index in colon cancer. External Web Site Icon
Zhao Minning et al. Cancer immunology, immunotherapy : CII 2021
The use of deep learning on endoscopic images to assess the response of rectal cancer after chemoradiation. External Web Site Icon
Haak Hester E et al. Surgical endoscopy 2021


Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.