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89 hot topic(s) found with the query "Telomeres"

Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure
N Aung et al, JAMA Cardiology, July 26, 2023 (Posted: Jul 26, 2023 0PM)

Is leukocyte telomere length (LTL) associated with alterations in cardiovascular structure and function? In this cross-sectional study including 40 459 UK Biobank participants, longer LTL was associated with higher left ventricular mass, larger ventricular and atrial sizes, and higher stroke volumes. Mendelian randomization analysis demonstrated a potential causal genetic association between LTL and left ventricular mass, ventricular size, and left ventricular stroke volume, and longer LTL was associated with a lower risk of incident heart failure after accounting for potential confounders.

The Role of Telomeres in Human Disease.
Mary Armanios et al. Annu Rev Genomics Hum Genet 2022 5 363-381 (Posted: Jul 25, 2023 8AM)

Short telomere syndromes are the most prevalent premature aging disorders, with prominent phenotypes affecting the lung and hematopoietic system. Less understood are a newly recognized group of cancer-prone syndromes that are associated with mutations that lengthen telomeres. A large body of new data from Mendelian genetics and epidemiology now provides an opportunity to reconsider paradigms related to the role of telomeres in human aging and cancer.

Telomere Length and Clonal Hematopoiesis.
George Vassiliou et al. N Engl J Med 2023 5 (26) 2481-2484 (Posted: Jun 29, 2023 7AM)

A recent study proposes a key role for telomere maintenance in the development of clonal hematopoiesis. Some persons with clonal hematopoiesis are at increased risk for the development of myeloid cancers such as acute myeloid leukemia or myelodysplastic syndromes, a risk that increases as the hematopoietic clone expands in size.16 Stopping this expansion may delay or avert leukemic progression, and therapeutic approaches to this end are being developed and tested.

Familial Clonal Hematopoiesis in a Long Telomere Syndrome.
Emily A DeBoy et al. N Engl J Med 2023 5 (26) 2422-2433 (Posted: Jun 29, 2023 7AM)

A total of 17 POT1 mutation carriers and 21 noncarrier relatives were initially included in the study, and a validation cohort of 6 additional mutation carriers was subsequently recruited. A majority of the POT1 mutation carriers with telomere length evaluated (9 of 13) had long telomeres (>99th percentile). POT1 mutation carriers had a range of benign and malignant neoplasms involving epithelial, mesenchymal, and neuronal tissues in addition to B- and T-cell lymphoma and myeloid cancers.

Link Between Long Telomeres and Long Life Is a Tall Tale, Study Finds
G Kolata, NY Times, May 4, 2023 (Posted: May 10, 2023 6AM)

The longer a person’s telomeres, researchers found, the greater the risk of cancer and other disorders, challenging a popular hypothesis about the chromosomal roots of vitality. While short telomeres do lead to health problems, long telomeres lead to health problems of their own. Far from extending life, long telomeres appear to cause cancer and a blood disorder known as CHIP, a condition that increases the risk of blood cancers and heart disease.

Genetic and Clinical Determinants of Telomere Length
P Allaire et al, HGG Advances, April 2023 (Posted: May 03, 2023 6AM)

Our GWAS confirmed 11 genetic loci previously associated with leucocyte telomere length (LTL) and two novel loci in SCNN1D and PITPNM1. PheWAS of LTL identified 67 distinct clinical phenotypes associated with both short and long LTL. We demonstrated that several diseases associated with LTL were related to one another but were largely independent from LTL genetics. Age of death was correlated with LTL independent of age.

Genetics of human telomere biology disorders.
Revy Patrick et al. Nature reviews. Genetics 2022 9 (Posted: Sep 27, 2022 8AM)

Numerous factors localize at telomeres to regulate their length, structure and function, to avert replicative senescence or genome instability and cell death. In humans, Mendelian defects in several of these factors can result in abnormally short or dysfunctional telomeres, causing a group of rare heterogeneous premature-ageing diseases, termed telomeropathies, short-telomere syndromes or telomere biology disorders (TBDs). Here, we review the TBD-causing genes identified so far and describe their main functions associated with telomere biology.

Association of Newborn Telomere Length With Blood Pressure in Childhood.
Martens Dries S et al. JAMA network open 2022 8 (8) e2225521 (Posted: Aug 06, 2022 6AM)

In this birth cohort study including 485 newborns, participants with a longer birth TL had a significantly lower diastolic and mean arterial pressure at the age of 4 to 6 years. Furthermore, longer newborn TL was significantly associated with lower odds of having high childhood blood pressure. These results suggest that TL at birth associates with early life vascular health and that newborn TL may be a programmed molecular mediator containing genetic and prenatal environmental exposure information contributing to vascular health later in life.

Polygenic basis and biomedical consequences of telomere length variation
V Codd et al, Nature Genetics, October 5,2021 (Posted: Oct 06, 2021 7AM)

We characterize the genetic architecture of naturally occurring variation in leukocyte telomere length (LTL) and identify causal links between LTL and biomedical phenotypes in 472,174 well-characterized UK Biobank participants. We identified 197 independent sentinel variants associated with LTL at 138 genomic loci (108 new). Genetically determined differences in LTL were associated with multiple biological traits, ranging from height to bone marrow function, as well as several diseases spanning neoplastic, vascular and inflammatory pathologies. We estimated that, at the age of 40?years, people with an LTL >1?s.d. shorter than the population mean had a 2.5-year-lower life expectancy compared with the group with =1?s.d. longer LDL.

Genomic and evolutionary classification of lung cancer in never smokers
T Zhang et al, Nature Genetics, September 6, 2021 (Posted: Sep 07, 2021 6AM)

Whole-genome sequencing of 232 LCINS showed 3 subtypes defined by copy number aberrations. The dominant subtype (piano), which is rare in lung cancer in smokers, features somatic UBA1 mutations, germline AR variants and stem cell-like properties, including low mutational burden, high intratumor heterogeneity, long telomeres, frequent KRAS mutations and slow growth, as suggested by the occurrence of cancer drivers’ progenitor cells many years before tumor diagnosis. The other subtypes are characterized by specific amplifications and EGFR mutations (mezzo-forte) and whole-genome doubling (forte). No strong tobacco smoking signatures were detected, even in cases with exposure to secondhand tobacco smoke.

Association of leucocyte telomere length with frailty: a large-scale cross-sectional analysis in UK Biobank
V Bountziouka et al, MEDRXIV, June 13, 2021 (Posted: Jun 14, 2021 6AM)

Telomere biology disorders
MLW Kam et al, NPJ Genomic Medicine, May 28, 2021 (Posted: May 29, 2021 9AM)

A constellation of bone marrow failure, pulmonary fibrosis, liver cirrhosis and premature greying is suggestive, however incomplete penetrance results in highly variable manifestations, with idiopathic pulmonary fibrosis as the most common presentation. Currently, the true extent of TBD burden is unknown as there is no established diagnostic criteria and the disorder often is unrecognized.

Polygenic basis and biomedical consequences of telomere length variation
V Codd et al, MEDRXIV, March 24, 2021 (Posted: Mar 25, 2021 8AM)

We characterize the genetic architecture of naturally-occurring variation in leucocyte telomere length (LTL) and identify causal links between LTL and biomedical phenotypes in 472,174 well-characterized participants in UK Biobank. We identified 197 independent sentinel variants associated with LTL at 138 genomic loci (108 novel).

A Mendelian randomization study of telomere length and blood-cell traits
CDC Adams et al, MEDRXIV, June 3, 2020 (Posted: Jun 04, 2020 7AM)

Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies
KG Arbeev et al, JAMA Network Open, February 26, 2020t (Posted: Feb 27, 2020 7AM)

This cohort study included 3259 participants from 3 longitudinal studies, of whom 1525 died during the follow-up period. Leukocyte telomere length–associated mortality from noncancer causes increased as participants aged, approaching their age at death. These data suggest that leukocyte telomere length is associated with a life span limit among contemporary humans.

Tobacco smoking and somatic mutations in human bronchial epithelium.
Yoshida Kenichi et al. Nature 2020 Jan (Posted: Jan 31, 2020 9AM)

A population of cells in individuals with a history of smoking had mutational burdens that were equivalent to those expected for people who had never smoked: these cells had less damage from tobacco-specific mutational processes, were fourfold more frequent in ex-smokers than current smokers and had longer telomeres than their more-mutated counterparts.

Novel genetic determinants of telomere length from a multi-ethnic analysis of 75,000 whole genome sequences in TOPMed
MA Taub et al, BioRXIV preprints, September 4, 2019 (Posted: Sep 05, 2019 8AM)

Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival
T Hamada et al, CEBP, August 2019 (Posted: Aug 29, 2019 8AM)

Targeting Telomeres and Telomerase: Studies in Aging and Disease Utilizing CRISPR/Cas9 Technology.
Brane Andrew C et al. Cells 2019 Feb (2) (Posted: Mar 04, 2019 2PM)

The telomere world and aging: Analytical challenges and future perspectives.
Mensà Emanuela et al. Ageing research reviews 2019 Jan 27-42 (Posted: Feb 14, 2019 9AM)

Mood Disorders, Accelerated Aging, and Inflammation: Is the Link Hidden in Telomeres?
Squassina Alessio et al. Cells 2019 Jan (1) (Posted: Feb 14, 2019 9AM)

Revisiting Telomere Shortening in Cancer.
Okamoto Keiji et al. Cells 2019 Jan (2) (Posted: Feb 14, 2019 9AM)

Telomere length and cardiovascular disease risk.
Zhan Yiqiang et al. Current opinion in cardiology 2019 Feb (Posted: Feb 14, 2019 9AM)

When the shoelaces fray: short telomere syndromes
BJ Toman, Mayo Clinic blog, February 14, 2019 (Posted: Feb 14, 2019 9AM)

Telomere Length as Cardiovascular Aging Biomarker
T De Meyer et al, JACC Review Topic of the Week, AUgust 7, 2018 (Posted: Aug 08, 2018 1PM)

Cryo-EM Images Capture Key Enzyme Tied to Cancer, Aging
NIH Director Blog, May 1, 2018 Brand (Posted: May 01, 2018 0PM)

Effects of Diet on Telomere Length: Systematic Review and Meta-Analysis.
Pérez Lisiane Marçal et al. Public health genomics 2018 Feb (Posted: Mar 04, 2018 7PM)

Short telomeres - A hallmark of heritable cardiomyopathies.
Chang Alex C Y et al. Differentiation; research in biological diversity 2018 Feb 10031-36 (Posted: Feb 28, 2018 10AM)

The future of telomere length in personalized medicine.
Gorenjak Vesna et al. Frontiers in bioscience (Landmark edition) 2018 Mar 231628-1654 (Posted: Jan 03, 2018 10AM)

Biological and clinical implications of telomere dysfunction in myeloid malignancies.
Kishtagari Ashwin et al. Therapeutic advances in hematology 2017 Nov (11) 317-326 (Posted: Dec 11, 2017 9AM)

Telomeres and Telomerase in Hematopoietic Dysfunction: Prognostic Implications and Pharmacological Interventions.
Vasko Theresa et al. International journal of molecular sciences 2017 Oct (11) (Posted: Dec 11, 2017 9AM)

Telomeres, Aging and Exercise: Guilty by Association?
Chilton Warrick et al. International journal of molecular sciences 2017 Nov (12) (Posted: Dec 11, 2017 9AM)

Diagnostic utility of telomere length measurement in a hospital setting
JK Alder et al, BioRXIV, Dec 2017 (Posted: Dec 11, 2017 9AM)

Telomere Length and Childhood Stress Don’t Always Correlate
K Zimmer, the Scientist, Nov 17, 2017 (Posted: Nov 19, 2017 8AM)

Is telomere length associated with the cognitive response to a lifestyle intervention?
Science Mag, August 30, 2017 (Posted: Sep 01, 2017 8AM)

Ancestry, Telomere Length, and Atherosclerosis Risk.
Benetos Athanase et al. Circulation. Cardiovascular genetics 2017 Jun (3) (Posted: Aug 09, 2017 0PM)

Telomeres and telomerase in prostate cancer development and therapy.
Graham Mindy Kim et al. Nature reviews. Urology 2017 Jul (Posted: Aug 09, 2017 0PM)

Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis.
Astuti Yuliana et al. Environmental research 2017 Jul 480-489 (Posted: Aug 09, 2017 0PM)

Decoding Telomere Biology and Cancer Risk
NIH Intramural Research, 2017 Brand (Posted: Aug 09, 2017 0PM)

Telomere length predicts cancer risk
Science Magazine, April 3, 2017 (Posted: Apr 04, 2017 8PM)

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases
JAMA Oncology, February 23, 2017 (Posted: Feb 26, 2017 9AM)

Telomeres in cancer: tumour suppression and genome instability.
Maciejowski John et al. Nature reviews. Molecular cell biology 2017 01 (Posted: Feb 10, 2017 1PM)

Telomere Length and Breast Cancer Prognosis: A Systematic Review
KE Idrissi et al, CEBP, January 2017 (Posted: Feb 10, 2017 1PM)

Elizabeth Blackburn on the telomere effect: ‘It’s about keeping healthier for longer’
The Guardian, February 2017 (Posted: Feb 06, 2017 8AM)

Systematic analysis of telomere length and somatic alterations in 31 cancer types
FB Barthel et al, Nature Genetics, January 30, 2017 (Posted: Jan 31, 2017 8AM)

Telomeres and telomerase in the clinical management of colorectal cancer.
Piñol-Felis C et al. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2016 Oct (Posted: Jan 03, 2017 11AM)

Role of telomeres and associated maintenance genes in Type 2 Diabetes Mellitus: A review.
Sethi Itty et al. Diabetes research and clinical practice 2016 Dec 92-100 (Posted: Jan 03, 2017 11AM)

You may have more control over aging than you think, say ‘The Telomere Effect’ authors
K Weintraub, StatNews, January 3, 2017 (Posted: Jan 03, 2017 11AM)

Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults
Rehkopf D et al, PLOS Medicine, November 2016 (Posted: Nov 29, 2016 3PM)

Racial and Socioeconomic Variation in Genetic Markers of Telomere Length: A Cross-Sectional Study of U.S. Older Adults
R Hamad et al, Ebiomedicine, August 2016 (Posted: Aug 22, 2016 2PM)

Telomere Length: The Intersection of Sociology, Molecular Biology, and Human Disease
BT Joyce et al, Ebiomedicine, August 2016 (Posted: Aug 22, 2016 2PM)

Long telomeres and cancer risk among 95568 individuals from the general population
L Rode et al, Int Journal Epidemiology, August 2016 (Posted: Aug 08, 2016 1PM)

Therapeutic Targeting of Telomerase.
Jäger Kathrin et al. Genes 2016 (7) (Posted: Aug 07, 2016 4PM)

Telomere-associated aging disorders.
Opresko Patricia L et al. Ageing research reviews 2016 May (Posted: Jun 20, 2016 6PM)

Telomere and Telomerase Therapeutics in Cancer.
Xu Yucheng et al. Genes 2016 (6) (Posted: Jun 20, 2016 6PM)

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
M Jafri et al, Genome Medicine, June 20, 2016 (Posted: Jun 20, 2016 6PM)

Increase of Telomere Length by a Sex Hormone
NEJM Video, May 18, 2016 (Posted: May 18, 2016 6PM)

Danazol Treatment for Telomere Diseases
DM Townsley et al, NEJM, May 18, 2016 (Posted: May 18, 2016 6PM)

The epigenetic clock and telomere length are independently associated with chronological age and mortality
RE Marioni, Int J Epidemiology, April 2016 (Posted: Apr 19, 2016 9PM)

The association between telomere length and cancer risk in population studies.
Zhu Xun et al. Scientific reports 2016 22243 (Posted: Apr 07, 2016 9PM)

Changes of telomere status with aging: An update.
Ishikawa Naoshi et al. Geriatrics & gerontology international 2016 Mar 30-42 (Posted: Apr 07, 2016 9PM)

Telomere attrition and diabetes mellitus.
Tamura Yoshiaki et al. Geriatrics & gerontology international 2016 Mar 66-74 (Posted: Apr 07, 2016 9PM)

Role of Telomeres and Telomerase in Aging and Cancer.
Shay Jerry W et al. Cancer discovery 2016 Mar (Posted: Apr 07, 2016 9PM)

Predicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Study
D Gei et al., PLOS ONE< APril 2016 (Posted: Apr 07, 2016 9PM)

Do telomeres have a higher plasticity than thought? Results from the German Chronic Kidney Disease (GCKD) study as a high-risk population.
Raschenberger Julia et al. Experimental gerontology 2015 Dec 162-6 (Posted: Dec 15, 2015 0PM)

Commentary: The reliability of telomere length measurements
S Verhulst et al. International Journal Epidemiology, September 24, 2015 (Posted: Sep 26, 2015 4PM)

Leukocyte telomere length dynamics in women and men: menopause vs age effects
C Dalgard et al. Int J Epidemiol, September 2015 (Posted: Sep 20, 2015 0PM)

Genetic and epigenetic trends in telomere research: a novel way in immunoepigenetics.
Melicher Dora et al. Cell. Mol. Life Sci. 2015 Jul 20. (Posted: Sep 20, 2015 0PM)

The short and long telomere syndromes: paired paradigms for molecular medicine.
Stanley Susan E et al. Curr. Opin. Genet. Dev. 2015 Jul 28. 1-9 (Posted: Sep 20, 2015 0PM)

The wide-ranging clinical implications of the Short Telomere Syndromes.
Barbaro Pasquale et al. Intern Med J 2015 Aug 6. (Posted: Sep 20, 2015 0PM)

Questioning causal involvement of telomeres in aging.
Simons Mirre J P et al. Ageing Res. Rev. 2015 Aug 21. (Posted: Sep 20, 2015 0PM)

Is childhood stress associated with shorter telomeres?
Næss Ane Brandtzæg et al. Tidsskr. Nor. Laegeforen. 2015 Aug (15) 1356-1360 (Posted: Sep 20, 2015 0PM)

Telomere length and the risk of cutaneous melanoma and non-melanoma skin cancer: a review of the literature and meta-analysis.
Caini Saverio et al. J. Dermatol. Sci. 2015 Aug 22. (Posted: Sep 20, 2015 0PM)

Telomere maintenance and the etiology of adult glioma.
Walsh Kyle M et al. Neuro-oncology 2015 May 25. (Posted: Jul 13, 2015 11AM)

Cardiorespiratory Capacity and Leukocyte Telomere Length Among Adults in the United States
PF Loprinzi. Int J Epidemiology, July 2015 (Posted: Jul 13, 2015 11AM)

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.
Lindqvist Daniel et al. Neurosci Biobehav Rev 2015 May 18. 333-364 (Posted: Jul 13, 2015 11AM)

Poverty, Race and Telomeres
GenomeWeb, May 11, 2015 (Posted: May 14, 2015 8AM)

Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort
L Hou et al.Ebiomedicine, April 2015 (Posted: May 03, 2015 6PM)

Are Telomeres The Key To Aging And Cancer?
University of Utah, Learn Genetics Website (Posted: May 02, 2015 8AM)

mRNA deadenylation and telomere disease.
Mason Philip J et al. J. Clin. Invest. 2015 May 1. (5) 1796-1798 (Posted: May 02, 2015 8AM)

Widespread telomere instability in prostatic lesions.
Tu LiRen et al. Mol. Carcinog. 2015 Apr 27. (Posted: May 02, 2015 8AM)

Computel: computation of mean telomere length from whole-genome next-generation sequencing data.
Nersisyan Lilit et al. PLoS ONE 2015 (4) e0125201 (Posted: May 02, 2015 8AM)

Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample.
Geronimus Arline T et al. J Health Soc Behav 2015 Apr 30. (Posted: May 02, 2015 8AM)

Telomere length as a marker of sleep loss and sleep disturbances: a potential link between sleep and cellular senescence.
Tempaku Priscila F et al. Sleep Med. 2015 Feb 14. (Posted: May 02, 2015 8AM)

From cellular senescence to Alzheimer's disease: The role of telomere shortening.
Boccardi Virginia et al. Ageing Res. Rev. 2015 Apr 17. 1-8 (Posted: May 02, 2015 8AM)

The long-term impact of adverse caregiving environments on epigenetic modifications and telomeres.
Blaze Jennifer et al. Front Behav Neurosci 2015 79 (Posted: May 02, 2015 8AM)

Telomere length and telomerase in a well-characterized sample of individuals with major depressive disorder compared to controls.
Simon Naomi M et al. Psychoneuroendocrinology 2015 Apr 13. 9-22 (Posted: May 02, 2015 8AM)

The role of telomeres and vitamin D in cellular aging and age-related diseases.
Pusceddu Irene et al. Clin. Chem. Lab. Med. 2015 Mar 21. (Posted: May 01, 2015 9AM)

Tell me more about telomeres
Brand (Posted: Feb 25, 2015 0PM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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