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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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104 hot topic(s) found with the query "Biobanks"

Research biobank participants attitudes towards genetic exceptionalism and health record confidentiality.
Victoria Dortenzio et al. J Community Genet 2024 3 (Posted: Apr 08, 2024 9AM)

From the abstract: "The goals of this study were to determine biobank participants’ attitudes towards genetic exceptionalism and confidentiality and whether those attitudes are related to their preference for return of genetic results. An online questionnaire was distributed to patients with an EHR and email address who had previously enrolled in the BioMe Biobank program. Most participants responded with similar levels of concern in scenarios involving the use of genetic information and other types of health information, suggesting that participants want similar protections for genetic data as other types of sensitive health information, particularly mental health and family history records. "

Multi-ancestry polygenic mechanisms of type 2 diabetes
K Smith et al, Nature Medicine, March 6, 2024 (Posted: Mar 06, 2024 9AM)

From the abstract: "Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for which the underlying biological mechanisms are not fully understood. In this study, we identified multi-ancestry T2D genetic clusters by analyzing genetic data from diverse populations in 37 published T2D genome-wide association studies representing more than 1.4 million individuals. We implemented soft clustering with 650 T2D-associated genetic variants and 110 T2D-related traits, capturing known and novel T2D clusters with distinct cardiometabolic trait associations across two independent biobanks. "

Prospective study design and data analysis in UK Biobank.
Naomi E Allen et al. Sci Transl Med 2024 1 (729) eadf4428 (Posted: Jan 25, 2024 7AM)

From the abstract: " Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank’s study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide."

Revolutionizing Cancer Research: The Impact of Artificial Intelligence in Digital Biobanking
C Frascarelli et al, J Per Med, September 2023 (Posted: Sep 18, 2023 11AM)

From the abstract: "As digital pathology and artificial intelligence (AI) have entered the precision medicine arena, biobanks are progressively transitioning from mere biorepositories to integrated computational databanks. Consequently, the application of AI and machine learning on these biobank datasets holds huge potential to profoundly impact cancer research. Methods. In this paper, we explore how AI and machine learning can respond to the digital evolution of biobanks with flexibility, solutions, and effective services. "

Power of Public Investment in Curated Big Health Data.
Paula Anne Newman-Casey et al. JAMA Ophthalmol 2023 9 (Posted: Sep 08, 2023 9AM)

From the paper: "Public investment from the US and the UK in creating the UK Biobank and the All of Us databases has resulted in the generation of critical new knowledge to better understand human health. Both projects have created publicly available data sets to encourage researchers to leverage large quantities of data to identify patterns and advance health care. Moreover, each database has its unique strengths. The UK Biobank data set goes deep into genomics, metabolomics, brain, heart, and ocular imaging, providing granular and specific measurements to inform many fields of study. The All of Us data set includes biospecimens, linkages to electronic health records, and survey results."

Association of HLA diversity with the risk of 25 cancers in the UK Biobank
QL Wang et al, Ebiomedicine, May 2023 (Posted: May 05, 2023 9AM)

Participation bias in the UK Biobank distorts genetic associations and downstream analyses.
Tabea Schoeler et al. Nat Hum Behav 2023 4 (Posted: Apr 30, 2023 6AM)

To evaluate the impact of selective participation, we derived UK Biobank participation probabilities on the basis of 14 variables harmonized across the UK Biobank and a representative sample. We then conducted weighted genome-wide association analyses on 19 traits. Comparing the output from weighted genome-wide association analyses with that from standard genome-wide association analyses, we found that increasing representativeness led to changes in SNP effect sizes and identified novel SNP associations for 12 traits. While heritability estimates were less impacted by weighting (maximum change in h2, 5%), we found substantial discrepancies for genetic correlations (maximum change in rg, 0.31) and Mendelian randomization estimates (maximum change in ßSTD, 0.15) for socio-behavioral traits.

Addressing Equity, Diversity, and Inclusion in the Conduct and Reporting of Genetics Research.
Kara S Bagot et al. JAMA psychiatry 2023 4 (Posted: Apr 08, 2023 0PM)

Genetic research has often failed to address heterogeneity on a population level, with lack of sustained efforts by researchers and funding agencies to ensure diverse representation among cohorts in genetics studies and in biobanks. We encourage researchers to engage heterogeneous, representative cohorts in genetics research. This will not only improve generalizability of findings but also provide greater understanding of mechanisms of disease among the diverse communities that psychiatrists engage and treat, thus improving health outcomes on the population level.

Analysis of genetic dominance in the UK Biobank.
Duncan S Palmer et al. Science (New York, N.Y.) 2023 3 (6639) 1341-1348 (Posted: Apr 06, 2023 9AM)

We evaluated the contribution of nonadditive genetic effects on trait variation across 1060 traits in the UK Biobank. We identified a modest number of loci and confirmed that heritability explained by dominance is small, in line with previous analyses. Our results support the robustness of the additive model when modeling human complex traits, consistent with the view that most common variants induce small perturbations of continuous latent biological processes aggregated by a mean-field approximation.

Public's awareness of biobanks and willingness to participate in biobanking: the moderating role of social value orientation.
Grežo Matúš et al. Journal of community genetics 2023 1 (Posted: Jan 22, 2023 8AM)

Genetic futurism.
et al. Nature genetics 2022 12 (12) 1757 (Posted: Dec 16, 2022 8AM)

Large-scale genotyping and phenotyping efforts, including biobanks, have revolutionized our understanding of the genetic architecture of human traits and diseases. Years of ever-larger genome-wide association studies (GWAS) have produced a catalog of genetic variants that contribute to complex traits. A corollary of this research has been the development of personalized polygenic scores (PGS) or polygenic risk scores (PRS).

Biobanking as a Tool for Genomic Research: From Allele Frequencies to Cross-Ancestry Association Studies
TE Lazavera et al, J Per Med, December 9, 2022 (Posted: Dec 10, 2022 7AM)

We summarize the main directions in which biobanks aid medical genetics and genomic research, from providing reference allele frequency information to allowing large-scale cross-ancestry meta-analyses. The largest biobanks greatly vary in the size of the collection, and the amount of available phenotype and genotype data. Nevertheless, all of them are extensively used in genomics, providing a rich resource for genome-wide association analysis, genetic epidemiology, and statistical research into the structure, function, and evolution of the human genome.

Multimodal biomedical AI.
Acosta Julián N et al. Nature medicine 2022 9 (Posted: Sep 20, 2022 5AM)

The increasing availability of biomedical data from large biobanks, electronic health records, medical imaging, wearable and ambient biosensors, and the lower cost of genome and microbiome sequencing have set the stage for the development of multimodal artificial intelligence solutions that capture the complexity of human health and disease. In this Review, we outline the key applications enabled, along with the technical and analytical challenges.

Celebrating 20 years of UK Biobank
UK Biobank, YouTube video, March 28, 2022 (Posted: Mar 28, 2022 9AM)

A video reflecting on the past, present and future value of UK Biobank. UK Biobank is a large-scale biomedical database and research resource, containing in-depth genetic and health information from half a million UK participants. The database is regularly augmented with additional data and is globally accessible to approved researchers undertaking vital research into the most common and life-threatening diseases.

Analysis of rare genetic variation underlying cardiometabolic diseases and traits among 200,000 individuals in the UK Biobank
SJ Jurgens et al, Nature Genetics, February 17, 2022 (Posted: Feb 18, 2022 7AM)

Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic component, our understanding of these diseases remains incomplete. Here, we analyzed the contribution of rare variants to 57 diseases and 26 cardiometabolic traits, using data from 200,337 UK Biobank participants with whole-exome sequencing. We identified 57 gene-based associations.

Population-Based Penetrance of Deleterious Clinical Variants.
Forrest Iain S et al. JAMA 2022 1 (4) 350-359 (Posted: Jan 26, 2022 8AM)

This cohort study included 72?434 participants from 2 biobanks who had alleles for pathogenic or loss-of-function variants reported for 157 diseases. Among the 5360 pathogenic/loss-of-function variants, 4795 (89%) were associated with less than or equal to 5% risk difference for disease in individuals with the variant allele; pathogenic variants were associated with 6.9% mean penetrance and benign variants were associated with 0.85% mean penetrance. In these biobanks, the estimated penetrance of pathogenic/loss-of-function variants varied, but was generally associated with a small increase in the risk of disease.

Their DNA Hides a Warning, but They Don’t Want to Know What It Says
G Kolata, NY Times, January 21, 2022 (Posted: Jan 22, 2022 1PM)

What should happen when researchers, while sequencing a participant’s DNA as part of a large study, discover gene variants that increase the risk for conditions that might be prevented with medical treatment or surveillance? Some researchers believe they have an obligation to find the participants — often years after they provided a DNA sample — contact them, and tell them what they have found. But, some research subjects feel they have a right not to know. Is it ethical for doctors to let them insist they can opt out of learning more without first knowing the particular risk they are facing?

The Mass General Brigham Biobank Portal: an i2b2-based data repository linking disparate and high-dimensional patient data to support multimodal analytics.
Castro Victor M et al. Journal of the American Medical Informatics Association : JAMIA 2021 (Posted: Dec 07, 2021 1PM)

Insights Into Immune-Mediated Disease and Cancer Risk-Delivering on the Promise of UK Biobank Big Data.
Stewart Douglas R et al. JAMA oncology 2021 12 (Posted: Dec 03, 2021 11AM)

Large, longitudinal data sets derived from the electronic health records are powerful tools for discovery. A recent study extracted from the big data provided by the UK Biobank clinically and scientifically useful insights and estimates of cancer risk associated with immune-mediated disease.

Why the United States Needs a National, Coordinated Biobanking System.
Compton Carolyn et al. Annals of internal medicine 2021 11 (Posted: Nov 09, 2021 6AM)

The idea of a national networked biobanking initiative is not new. In 2003, the NCI developed and published a plan for such an entity, a public–private partnership that it called the National Biospecimen Network (NBN). In response to the lack of fit-for-purpose human specimens for proteomic and genomic research in cancer, the NBN aimed “to establish a national, pre-competitive, regulatory compliant and genetic-privacy protected, standardized, inclusive, highest quality network of biological sample(s) banks; supported by and developed via novel financial and other partnerships…that is shared, readily accessible, and searchable using state-of-the-art informatics systems.”

Rare variant contribution to human disease in 281,104 UK Biobank exomes
Q Wang et al, Nature, August 10, 2021 (Posted: Aug 10, 2021 3PM)

Genome-wide association studies have uncovered thousands of common variants associated with human disease, but the contribution of rare variation to common disease remains relatively unexplored. The UK Biobank (UKB) contains detailed phenotypic data linked to medical records for approximately 500,000 participants, offering an unprecedented opportunity to evaluate the impact of rare variation on a broad collection of traits

Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank.
Szustakowski Joseph D et al. Nature genetics 2021 6 (Posted: Jul 03, 2021 7AM)

Recognizing the need for large-scale human genetics data, as well as the unique value of the data access and contribution terms of the UKB, the UKB-ESC was formed. As a result, exome data from 200,643 UKB enrollees are now available. These data include ~10?million exonic variants—a rich resource of rare coding variation that is particularly valuable for drug discovery

Fine-scale genetic ancestry as a potential new tool for precision medicine
NP Tatonetti et al, Nature Medicine, June 18, 2021 (Posted: Jun 18, 2021 6AM)

Race and ethnicity (R/E) and genetic ancestry have long been conflated in biomedical research. The use of self-reported R/E as a proxy for genetic ancestry holds back precision medicine by confounding biological risks with those stemming from the environment, economic status, other socioeconomic factors and racism. The advent of large institutional biobanks connected to both genomic databases and electronic health records therefore represents an opportunity for disentangling the social and cultural from the ancestral.

From Genes to Public Health: Building the Evidence Base for DNA-based Population Screening
MJ Khoury et al, CDC Blog, April 9, 2021 Brand (Posted: Apr 10, 2021 7AM)

In the United States and other counties, the vision of DNA-based population screening has begun to be realized in multiple health systems, population-based biobanks and learning health systems research settings. Recently, the American College of Medical Genetics and Genomics published two guidance documents on DNA-based screening of healthy adults.

Preferences of biobank participants for receiving actionable genomic test results: results of a recontacting study.
Henrikson Nora B et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 Feb (Posted: Feb 20, 2021 0PM)

Efforts to recontact biobank participants can yield high response. Though active refusal upon recontact was common, our data do not support assuming initial nonresponse to be refusal. Future research can work toward best practices for reconsenting, especially when clinically actionable results are possible.

ESHG warns against misuses of genetic tests and biobanks for discrimination purposes.
Forzano Francesca et al. European journal of human genetics : EJHG 2021 Jan (Posted: Jan 19, 2021 8AM)

As members of ESHG, professionals working in genetics and genomics, we feel that we must point out the damage that such a collection may cause: first to those directly affected, but also to the reputation of academic and healthcare institutions (including ethics committees), companies and publishers, and the image of genetics in the wider world.

The intersection of genomics and big data with public health: Opportunities for precision public health.
Khoury Muin J et al. PLoS medicine 2020 Oct 17(10) e1003373 (Posted: Oct 30, 2020 10AM)

Precision public health (PPH) has emerged as a response to the increasing availability of genomics, biobanks, and other sources of big data in healthcare and public health. ?The field has evolved starting with genomics to include multiple practical applications such as pathogen genomics that address population health. ?PPH can expand understanding of health disparities, advance strategic public health science, and demonstrate the need for innovation and workforce development.

Host genetics may provide some answers to COVID-19, but only with the right questions
P Duggal et al, Medium blog, May 26, 2020 (Posted: May 27, 2020 7AM)

Large-scale biobanks and longitudinal cohorts provide rich medical histories with existing genetic data and the ability to recontact and test participants. Also, prospective studies that are able to capture clinical data may identify genes that influence different subgroups of COVID-19 individuals like those with thrombolytic events or neuro involvement.

BBMRI-ERIC’s contributions to research and knowledge exchange on COVID-19
P Holub et al, Eur J Hum Genetics, May 22, 2020 (Posted: May 22, 2020 0PM)

Future-proofing biobanks’ governance
F Gille et al, Eur J Hum Genetics, May 18, 2020 (Posted: May 19, 2020 7AM)

We reviewed information available on the websites of 69 biobanks, and directly contacted them for additional information. Our study identified six types of commonly adopted governance strategies: communication, compliance, expert advice, external review, internal procedures, and partnerships.

Researchers Suggest Genetics Might Be Behind Patient Response to COVID-19
M Terry, Biospace, April 8, 2020 (Posted: Apr 09, 2020 7AM)

The hope is that the results will provide insights on who is at unusually high or low risk, and to give clues to possible drugs that can be repurposed to prevent or treat the disease. A number of the world’s biggest biobanks are planning to participate, including the UK Biobank, deCODE Genetics and FinnGen.

Electronic health records and polygenic risk scores for predicting disease risk
R Li et al, Nat Rev Genetics, March 31, 2020 (Posted: Apr 06, 2020 8AM)

Increasingly, electronic health records (EHRs) are being linked to patient genetic data in biobanks, which provides new opportunities for developing and applying polygenic risk scores in the clinic, to systematically examine and evaluate patient susceptibilities to disease. However, the heterogeneous nature of EHR data brings forth many practical challenges.

Contributions of the UK biobank high impact papers in the era of precision medicine.
Glynn Peter et al. European journal of epidemiology 2020 Jan (Posted: Feb 02, 2020 9AM)

In this assessment of the first 7 years of the UK Biobank and first 4 years of genetic data availability, the majority of high impact UK Biobank studies either replicated known associations or generated novel associations without clinically relevant improvements in risk prediction, screening, or treatment.

Return of genetic and genomic research findings: experience of a pediatric biorepository.
Papaz Tanya et al. BMC medical genomics 2019 Nov (1) 173 (Posted: Dec 02, 2019 8AM)

Return of actionable research findings was faster if disclosed directly to the participant by a research genetic counselor. There was a high acceptability amongst participants for receiving the findings, for referral to clinical genetics, and for clinical validation of research findings.

Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
M Goisauf et al, PLOS ONE, September 2019 (Posted: Oct 02, 2019 8AM)

Powering discovery in blood disorders and depression
A Cranage, Sanger Institute, September 2019 (Posted: Sep 16, 2019 8AM)

"UK Biobank data is so vast, and so detailed. It has changed the way we do research in human genetics. We are beginning not only to understand the complex genetic basis of a whole variety of devastating human diseases, but also how to better use this genetic information to understand how to predict and treat these diseases.”

The generosity of 500,000 healthy volunteers could help us all
S Marshall, Wellcome Trust, September 11, 2019 (Posted: Sep 12, 2019 7AM)

UK Biobank's project to sequence the genomes of 500,000 participants will create a unique resource, that will help researchers to unlock new treatments and preventative measures for a wide range of diseases.

UK Biobank Requires Earth's Geneticists To Cooperate, Not Compete
R Harris, NPR, August 31, 2019 (Posted: Sep 03, 2019 8AM)

What makes UK Biobank valuable is not only the half-million volunteers, whose health will be followed for decades, but also its community-spirited scientific strategy. So far, 10,000 researchers from around the world have registered with the resource and we've now gone past 1,000 different research projects that are ongoing.

Biobanking Is Changing The World
J Pandya, Forbes, August 12, 2019 (Posted: Aug 14, 2019 8AM)

Biobanking is here. Artificial Intelligence-driven process automation, data analytics, robotics, the internet, and other rapidly emerging technological advances are driving the revolution of biobanks, biorepositories, and biospecimen science.

The advantages of UK Biobank's open access strategy for health research
Conroy, M. et. al. JIM Journal of Internal Medicine, Jul 8, 2019 (Posted: Jul 15, 2019 9AM)

The UK Biobank is an unparallel resource for public health research in genomics and precision health. It is also an exemplar for the development of open access approaches for other studies and Biobank.

Blood samples reveal valuable data — and life-changing surprises for donors
PD McCluskey, Boston Globe, July 5, 2019 (Posted: Jul 09, 2019 10AM)

More than 103,000 patients have agreed to provide blood to the Partners HealthCare Biobank, and their samples are providing valuable data for some 200 studies about Alzheimer?s, depression, diabetes, epilepsy, heart disease, and other conditions. But the research initiative is also having another impact, one that is more personal and immediate: It?s revealing genetic red flags that patients otherwise might never have seen.

Genomics of disease risk in globally diverse populations
G Gurdasani et al, Nature Rev Genetics, June 24, 2019 (Posted: Jun 24, 2019 9AM)

Large-scale multi-ethnic and representative biobanks and population health resources provide unprecedented opportunities to understand the genetic determinants of disease on a global scale.

New genetic data on 50,000 UK Biobank participants made available to the global health research community
UK Biobank, March 10, 2019 (Posted: Mar 11, 2019 9AM)

UK Biobank Published papers
UK Biobank, 2019 (Posted: Jan 24, 2019 8AM)

Huge trove of British biodata is unlocking secrets of depression, sexual orientation, and more
J Kaiser et al, Science, January 3, 2019 (Posted: Jan 04, 2019 9AM)

Biology in the bank
J Kaiser et al, Science, January 3, 2019 (Posted: Jan 04, 2019 9AM)

UK Biobank debuts as a powerful resource for genomic research
T Manolio, Nature News, December 3, 2018 (Posted: Dec 05, 2018 8PM)

Impact of biobanks on research outcomes in rare diseases: a systematic review.
Garcia Monique et al. Orphanet journal of rare diseases 2018 Nov 13(1) 202 (Posted: Nov 14, 2018 11AM)

UK Biobank — a new era in genomic medicine
OG Bahcall, Nat Rev Genetics, October 23, 2018 (Posted: Oct 24, 2018 8AM)

The UK Biobank resource with deep phenotyping and genomic data.
Bycroft Clare et al. Nature 2018 Oct (7726) 203-209 (Posted: Oct 15, 2018 10AM)

UK Biobank shares the promise of big data
N Cox, Nature News, October 10, 2018 (Posted: Oct 15, 2018 10AM)

How 500,000 Britons are critical to assessing global disease risk UK Biobank volunteers help develop genetic tests for common disorders worldwide
C Elwell, August 22, 2018 (Posted: Aug 27, 2018 2PM)

Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics
G McInnes et al, BioRXIV, Apr 22, 2018 (Posted: Apr 22, 2018 0PM)

The next generation of precision medicine: observational studies, electronic health records, biobanks, and continuous monitoring.
Glicksberg Benjamin S et al. Human molecular genetics 2018 Apr (Posted: Apr 18, 2018 10AM)

Whole genome sequencing will ‘transform the research landscape for a wide range of diseases’
US Biobank, Apr 5, 2018 (Posted: Apr 06, 2018 7AM)

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results.
Rovite Vita et al. Journal of epidemiology 2018 Mar (Posted: Mar 27, 2018 1PM)

Estonia offers 100,000 citizens free genetic testing
Insights, HIMSS Europe, Mar 20, 2018 (Posted: Mar 23, 2018 1PM)

The Struggle to Build a Massive ‘Biobank’ of Patient Data
G Kolata, Mar 19, 2018 (Posted: Mar 19, 2018 8AM)

Finnish researchers to create DNA database of 500,000 people for disease studies
Yle news, January 17, 2018 (Posted: Jan 17, 2018 7PM)

Perceptions of legislation relating to the sharing of genomic biobank results with donors-a survey of BBMRI-ERIC biobanks.
Brunfeldt Minna et al. European journal of human genetics : EJHG 2018 Jan (Posted: Jan 17, 2018 11AM)

Regeneron Forms Consortium of Leading Life Sciences Companies to Accelerate Largest Widely-Available 'Big Data' Human Sequencing Resource with UK Biobank
Regeneron, Jan 9, 2018 (Posted: Jan 09, 2018 7AM)

500,000 Britons’ Genomes Will Be Public by 2020, Transforming Drug Research
A Regalado, Tech Review, Jan 9, 2018 (Posted: Jan 09, 2018 7AM)

Genetics and biobanks converge to resolve a vexing knowledge gap in diabetes
JC Florez, Lancet, Nov 30, 2017 (Posted: Dec 01, 2017 9AM)

What Happens When You Put 500,000 People's DNA Online
S Zhang, The Atlantic, Nov 6, 2017 (Posted: Nov 06, 2017 2PM)

High participation rate among 25 721 patients with broad age range in a hospital-based research project involving whole-genome sequencing - the Lausanne Institutional Biobank.
Bochud Murielle et al. Swiss medical weekly 2017 Oct 147w14528 (Posted: Oct 25, 2017 8AM)

Reaching for the next branch on the biobank tree of knowledge
NJ Cox, Nature Genetics, August 30, 2017 (Posted: Aug 31, 2017 0PM)

Participants' Understanding of Informed Consent for Biobanking: A Systematic Review.
Eisenhauer Elizabeth R et al. Clinical nursing research 2017 Jul 1054773817722690 (Posted: Aug 02, 2017 8AM)

Genetic data from half a million released for research
Medical research Council, UK, July 28, 2017 (Posted: Aug 01, 2017 10AM)

Genes, cells, and biobanks: Yes, there’s still a consent problem
T Caulfield et al, PLOS Biology, July 25, 2017 (Posted: Jul 27, 2017 8AM)

Genome-wide genetic data on ~500,000 UK Biobank participants
C Bycroft et al. BioRxiV, July 20, 2017 (Posted: Jul 24, 2017 2PM)

Has the biobank bubble burst? Withstanding the challenges for sustainable biobanking in the digital era.
Chalmers Don et al. BMC medical ethics 2016 Jul (1) 39 (Posted: Jun 30, 2017 1PM)

Balancing the Local and the Universal in Maintaining Ethical Access to a Genomics Biobank
C Heeney et al, BioRXiv, June 2017 (Posted: Jun 30, 2017 1PM)

Engaging a state: Facebook comments on a large population biobank.
Platt Tevah et al. Journal of community genetics 2017 Apr (Posted: Apr 12, 2017 8AM)

Public Attitudes toward Consent and Data Sharing in Biobank Research: A Large Multi-site Experimental Survey in the US.
Sanderson Saskia C et al. American journal of human genetics 2017 Mar 100(3) 414-427 (Posted: Apr 12, 2017 8AM)

Community recommendations on biobank governance: Results from a deliberative community engagement in California.
Dry Sarah M et al. PloS one 2017 12(2) e0172582 (Posted: Apr 12, 2017 8AM)

Genetic Testing and Molecular Biomarkers
Genetic Testing & Biomarkers, March 2017 (Posted: Apr 03, 2017 2PM)

Regulation of genomic and biobanking research in Africa: a content analysis of ethics guidelines, policies and procedures from 22 African countries.
de Vries Jantina et al. BMC medical ethics 2017 Feb 18(1) 8 (Posted: Feb 08, 2017 9AM)

Whose Biobank? Should Biobanks Serve Research Interests or the Needs for Personalized Medicine? Analysis of the Hungarian Law.
Sándor Judit et al. Genetic testing and molecular biomarkers 2017 Jan (Posted: Jan 25, 2017 10AM)

Biobank attributes associated with higher patient participation: a randomized study.
Gayet-Ageron Angèle et al. European journal of human genetics : EJHG 2016 Oct (Posted: Oct 16, 2016 8AM)

"It's all about trust": reflections of researchers on the complexity and controversy surrounding biobanking in South Africa.
Moodley Keymanthri et al. BMC medical ethics 2016 Oct (1) 57 (Posted: Oct 16, 2016 8AM)

Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies.
Bins Sander et al. The oncologist 2016 Sep (Posted: Sep 27, 2016 11AM)

Ethics Reporting in Biospecimen and Genetic Research: Current Practice and Suggestions for Changes.
Chin William Wei Lim et al. PLoS biology 2016 Aug 14(8) e1002521 (Posted: Aug 10, 2016 9AM)

The Sangre Por Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community.
Shaibi Gabriel et al. Public health genomics 2016 Jul (Posted: Jul 27, 2016 10AM)

Understanding public reactions to commercialization of biobanks and use of biobank resources.
Nicol Dianne et al. Social science & medicine (1982) 2016 Jun 16279-87 (Posted: Jun 29, 2016 1PM)

Implementation of Electronic Consent at a Biobank: An Opportunity for Precision Medicine Research.
Boutin Natalie T et al. Journal of personalized medicine 2016 6(2) (Posted: Jun 15, 2016 10AM)

Broad Consent for Genomic Research and Biobanking: Perspectives from Low- and Middle-Income Countries.
Tindana Paulina et al. Annual review of genomics and human genetics 2016 Feb (Posted: Mar 02, 2016 9AM)

Building the Partners HealthCare Biobank at Partners Personalized Medicine: Informed Consent, Return of Research Results, Recruitment Lessons and Operational Considerations.
Karlson Elizabeth W et al. Journal of personalized medicine 6(1) (Posted: Jan 20, 2016 11AM)

Identifying public expectations of genetic biobanks.
Critchley Christine et al. Public understanding of science (Bristol, England) 2016 Jan (Posted: Jan 20, 2016 11AM)

Biobanks, Data Sharing, and the Drive for a Global Privacy Governance Framework.
Dove Edward S et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2015 Dec (4) 675-89 (Posted: Jan 06, 2016 7PM)

International Guidelines for Privacy in Genomic Biobanking (or the Unexpected Virtue of Pluralism).
Thorogood Adrian et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2015 Dec (4) 690-702 (Posted: Jan 06, 2016 9AM)

Genomic Databases and Biobanks in Israel.
Siegal Gil et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2015 Dec (4) 766-75 (Posted: Jan 06, 2016 9AM)

Regulation of Biobanks in France.
Rial-Sebbag Emmanuelle et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2015 Dec (4) 754-65 (Posted: Jan 06, 2016 9AM)

Spanish Regulation of Biobanks.
Nicolás Pilar et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2015 Dec (4) 801-15 (Posted: Jan 06, 2016 9AM)

Genomic Databases and Biobanks in Denmark.
Hartlev Mette et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2015 Dec (4) 743-53 (Posted: Jan 06, 2016 9AM)

Biobanking and Privacy Law in Brazil.
Dallari Sueli Gandolfi et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2015 Dec (4) 714-25 (Posted: Jan 06, 2016 9AM)

Biobanking and Privacy Laws in Australia.
Chalmers Don et al. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2015 Dec (4) 703-13 (Posted: Jan 06, 2016 9AM)

Returning a Research Participant's Genomic Results to Relatives: Perspectives from Managers of Two Distinct Research Biobanks
GM Petersen et al. J Law, Medicine and Ethics, Fall 2015 (Posted: Oct 21, 2015 7PM)

Million Veteran Program (MVP): A Mega-Biobank to Study Genetic Influences On Health and Disease.
Gaziano John Michael et al. Journal of clinical epidemiology 2015 Oct (Posted: Oct 14, 2015 11AM)

Estonia Wants to Collect the DNA of All Its Citizens
the Atlantic, October 2015 (Posted: Oct 12, 2015 8AM)

Biobanks and the future of genome research
Genome Magazine, September 30, 2015 (Posted: Oct 05, 2015 9AM)

more


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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