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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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37 hot topic(s) found with the query "Rheumatoid arthritis"

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.
Ishigaki Kazuyoshi et al. Nature genetics 2022 11 (Posted: Nov 06, 2022 8AM)

We present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P?<?5?×?10-8), of which 34 are novel. Candidate genes at the novel loci suggest essential roles of the immune system (for example, TNIP2 and TNFRSF11A) and joint tissues (for example, WISP1) in RA etiology. PRS based on multi-ancestry GWAS outperformed PRS based on single-ancestry GWAS and had comparable performance between populations of European and East Asian ancestries.

Provocateurs of autoimmunity within the gut microbiota.
Upadhyay Rabi et al. Science translational medicine 2022 10 (668) eadd3901 (Posted: Oct 27, 2022 9AM)

A challenge in the field of microbiota-host interactions has been the difficulty in progressing from correlation to demonstration of causality in the relationship between colonizing bacterial species or communities and disease. A recent study provides strong support for an important role of intestinal microbes in Rheumatoid Arthritis (RA) pathogenesis. Previous studies showed an association in new-onset RA patients with P. copri colonization and, potentially, selective priming of P. copri antigen–specific T cells in patients with RA.

Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate
KH van der Pol et al, EJHG, September 2, 2022 (Posted: Sep 02, 2022 9AM)

This guideline describes the gene-drug interaction of ABCG2 with allopurinol, HLA-B with allopurinol, MTHFR with folic acid, and MTHFR with methotrexate, relevant for the treatment of gout, cancer, and rheumatoid arthritis. A systematic review was performed based on which pharmacotherapeutic recommendations were developed.

Inching closer to precision treatment for rheumatoid arthritis
LT Donlin, Nature Medicine, June 9, 2022 (Posted: Jun 10, 2022 6AM)

Designing precision medicine treatment strategies for rheumatoid arthritis (RA) is an imperative, yet a humbling challenge. Successful examples of precision treatment have, thus far, largely involved conditions where a single causal genomic variant was identified and a counteracting drug was developed. For RA and most autoimmune conditions, however, precise causal mechanisms remain unclear. Fortunately, more than 20 medications are approved for RA and show efficacy in at least a fraction of patients.

Immunogenicity of the third and fourth BNT162b2 mRNA COVID-19 boosters and factors associated with immune response in systemic lupus erythematosus and rheumatoid arthritis patients
T Assawasaksakul et al, MEDRXIV, March 15, 2022 (Posted: Mar 16, 2022 8AM)

Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US
J Sun et al, JAMA Internal Medicine, December 28, 2021 (Posted: Dec 28, 2021 2PM)

Is immune dysfunction associated with an increased risk for COVID-19 breakthrough infection after SARS-CoV-2 vaccination? In this cohort study of 664?722 patients who received at least 1 dose of a SARS-CoV-2 vaccine, those with immune dysfunction, such as HIV infection, rheumatoid arthritis, and solid organ transplant, had a higher rate for COVID-19 breakthrough infection and worse outcomes after full or partial vaccination, compared with persons without immune dysfunction.

Assessment of a Deep Learning Model Based on Electronic Health Record Data to Forecast Clinical Outcomes in Patients With Rheumatoid Arthritis
B Norgeot et al, JAMA Network Open, March 15, 2019 (Posted: Mar 19, 2019 7AM)

Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data.
Cherlin Svetlana et al. Genetic epidemiology 2018 Oct (Posted: Oct 28, 2018 8AM)

Breathing New Life into Interstitial Lung Disease in Rheumatoid Arthritis
PK Gergersen et al, NEJM, October 20, 2018 (Posted: Oct 21, 2018 2PM)

Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission.
Tasaki Shinya et al. Nature communications 2018 Jul (1) 2755 (Posted: Jul 19, 2018 9AM)

Predictors of Treatment Response in Rheumatoid Arthritis.
Lequerré Thierry et al. Joint, bone, spine : revue du rhumatisme 2018 Jul (Posted: Jul 10, 2018 8AM)

Update on the genetic architecture of rheumatoid arthritis.
Kim Kwangwoo et al. Nature reviews. Rheumatology 2017 Jan (1) 13-24 (Posted: Mar 08, 2017 10AM)

A clinical update on the significance of the gut microbiota in systemic autoimmunity.
Rosser Elizabeth C et al. Journal of autoimmunity 2016 Jul (Posted: Aug 23, 2016 9AM)

Cardiovascular risk assessment in patients with rheumatoid arthritis: The relevance of clinical, genetic and serological markers.
López-Mejías Raquel et al. Autoimmunity reviews 2016 Aug (Posted: Aug 23, 2016 9AM)

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
SK Sieberts et al, Nature Communications, August 23, 2016 (Posted: Aug 23, 2016 9AM)

Gut Bacteria Can Cause, Predict and Prevent Rheumatoid Arthritis
S Rosen, Mayo Clinic Blog, July 12, 2016 (Posted: Jul 13, 2016 6AM)

Emerging aspects of molecular biomarkers for diagnosis, prognosis and treatment response in rheumatoid arthritis.
Márquez Ana et al. Expert review of molecular diagnostics 2016 Jun (6) 663-75 (Posted: May 21, 2016 8AM)

Family history of rheumatoid arthritis: an old concept with new developments.
Frisell Thomas et al. Nature reviews. Rheumatology 2016 Apr (Posted: May 21, 2016 8AM)

Rheumatoid arthritis
Brand (Posted: Apr 30, 2016 0AM)

Genetic data: The new challenge of personalized medicine, insights for rheumatoid arthritis patients.
Goulielmos George N et al. Gene 2016 Jun (2) 90-101 (Posted: Apr 22, 2016 10AM)

Review - Rheumatoid arthritis: What have we learned about the causing factors?
Jalil Syed Fazal et al. Pakistan journal of pharmaceutical sciences 2016 Mar (2) 629-45 (Posted: Apr 22, 2016 10AM)

From genetics to functional insights into rheumatoid arthritis.
Suzuki Akari et al. Clinical and experimental rheumatology 2015 Oct (Posted: Oct 15, 2015 6PM)

Germs and joints: the contribution of the human microbiome to rheumatoid arthritis
Geraint B Rogers, Nature Medicine, August 6, 2015 (Posted: Aug 07, 2015 9AM)

Comprehensive review of genetic association studies and meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility.
Fu Lingyu et al. Hum. Immunol. 2014 Sep 11. (Posted: Jul 20, 2015 1PM)

Does a family history of RA influence the clinical presentation and treatment response in RA?
Frisell Thomas et al. Ann. Rheum. Dis. 2015 Jun 19. (Posted: Jun 24, 2015 1PM)

RA Treatment Response Influenced by HLA-DRB1 Haplotype
JC Kelly, Medscape, Apr 28 [by free subscription only] (Posted: Apr 29, 2015 10AM)

Genetic contribution of DKK-1 polymorphisms to RA structural severity and DKK-1 level of expression.
Miceli-Richard Corinne et al. Ann. Rheum. Dis. 2015 Mar 24. (Posted: Apr 28, 2015 7PM)

FcGR genetic polymorphisms and the response to adalimumab in patients with rheumatoid arthritis.
Dávila-Fajardo Cristina Lucía et al. Pharmacogenomics 2015 Mar (4) 373-81 (Posted: Apr 28, 2015 7PM)

Variation at FCGR2A and Functionally Related Genes Is Associated with the Response to Anti-TNF Therapy in Rheumatoid Arthritis.
Avila-Pedretti Gabriela et al. PLoS ONE 2015 (4) e0122088 (Posted: Apr 28, 2015 7PM)

Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study.
Canet Luz M et al. Pharmacogenet. Genomics 2015 Apr 4. (Posted: Apr 28, 2015 7PM)

A genome-wide association study identifies a new locus associated with the response to anti-TNF therapy in rheumatoid arthritis.
Julià A et al. Pharmacogenomics J. 2015 Apr 21. (Posted: Apr 28, 2015 7PM)

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.
Ferreiro-Iglesias A et al. Pharmacogenomics J. 2015 Apr 21. (Posted: Apr 28, 2015 7PM)

Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis.
Furukawa Hiroshi et al. J. Hum. Genet. 2015 Apr 23. (Posted: Apr 28, 2015 7PM)

Genetic architectures of seropositive and seronegative rheumatic diseases.
Kirino Yohei et al. Nat Rev Rheumatol 2015 Apr 28. (Posted: Apr 28, 2015 7PM)

Association of HLA-DRB1 Haplotypes With Rheumatoid Arthritis Severity, Mortality, and Treatment Response
S Viatte et al. JAMA, April 28, 2015 (Posted: Apr 28, 2015 7PM)

To what extent is the familial risk of rheumatoid arthritis explained by established rheumatoid arthritis risk factors?
Jiang Xia et al. Arthritis & rheumatology (Hoboken, N.J.) 2015 Feb (2) 352-62 (Posted: Feb 12, 2015 8AM)

Restless Legs Syndrome
From NHLBI health topic site Brand (Posted: Jan 01, 2014 0AM)

What Is Restless legs syndrome (RLS) is a disorder that causes a strong urge to move your legs. This urge to move often occurs with strange and unpleasant feelings in your legs. Moving your legs relieves the urge and the unpleasant feelings. People who have RLS describe the unpleasant feelings as creeping, crawling, pulling, itching, tingling, burning, aching, or electric shocks. Sometimes, these feelings also occur in the arms. The urge to move and unpleasant feelings happen when you're resting and inactive. Thus, they tend to be worse in the evening and at night. Overview RLS can make it hard to fall asleep and stay asleep. It may make you feel tired and sleepy during the day. This can make it hard to learn, work, and do other daily activities. Not getting enough sleep also can cause depression, mood swings, or other health problems. RLS can range from mild to severe based on: ?The strength of your symptoms and how often they occur ?How easily moving around relieves your symptoms ?How much your symptoms disturb your sleep One type of RLS usually starts early in life (before 45 years of age) and tends to run in families. It may even start in childhood. Once this type of RLS starts, it usually lasts for the rest of your life. Over time, symptoms slowly get worse and occur more often. If you have a mild case, you may have long periods with no symptoms. Another type of RLS usually starts later in life (after 45 years of age). It generally doesn't run in families. This type of RLS tends to have a more abrupt onset. The symptoms usually don't get worse over time. Some diseases, conditions, and medicines may trigger RLS. For example, the disorder has been linked to kidney failure, Parkinson's disease, diabetes, rheumatoid arthritis, pregnancy, and iron deficiency. When a disease, condition, or medicine causes RLS, the symptoms usually start suddenly. Medical conditions or medicines often cause or worsen the type of RLS that starts later in life. Outlook RLS symptoms often get worse over time. However, some people's symptoms go away for weeks to months. If a medical condition or medicine triggers RLS, the disorder may go away if the trigger is relieved or stopped. For example, RLS that occurs due to pregnancy tends to go away after giving birth. Kidney transplants (but not dialysis) relieve RLS linked to kidney failure. Treatments for RLS include lifestyle changes and medicines. Some simple lifestyle changes often help relieve mild cases of RLS. Medicines often can relieve or prevent the symptoms of more severe RLS. Research is ongoing to better understand the causes of RLS and to find better treatments.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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