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Hot Topics of the Day|PHGKB
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12/29/2022

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The role of genetic testing in diagnosis and care of inherited cardiac conditions in a specialised multidisciplinary clinic
F Stafford et al, Genome Medicine, December 28, 2022

The diagnostic yield of genetic testing for inherited cardiac diseases is up to 40% and is primarily indicated for screening of at-risk relatives. Here, we evaluate the role of genomics in diagnosis and management among consecutive individuals attending a specialized clinic. A total of 888 probands fulfilled the inclusion criteria, and genetic testing identified likely pathogenic or pathogenic (LP/P) variants in 330 individuals (37%) and suspicious variants of uncertain significance (VUS) in 73 (8%).

Neutralization sensitivity, fusogenicity, and infectivity of Omicron subvariants
XJ wang et al, Genome Medicine, December 29, 2022

Omicron subvariants markedly escaped vaccine-elicited neutralizing antibodies after two doses of BBIBP-CorV with comparable efficiency. A third dose vaccination of BBIBP-CorV or ZF2001 increased neutralizing antibody titers and breadth against Delta and three Omicron subvariants. Delta and BA.1 breakthrough infections induced comparable neutralizing antibody titers against D614G and Delta variants, whereas BA.1 breakthrough infections elicited a stronger and broader antibody response against three Omicron subvariants than Delta breakthrough infections.

Omicron Subvariant XBB Jumps to 18% of US COVID Cases: CDC
Medscape, December 27, 2022

The highly contagious Omicron subvariant XBB has surged to more than 50% of COVID-19 cases in the northeastern United States and risks spreading fast as millions of Americans begin holiday travel. In the week ended Dec. 24, XBB was estimated to account for 18.3% of the COVID-19 cases in the United States, up from 11.2% in the previous week,

National Birth Defects Awareness Month: Healthy Communities, Healthy Babies
NBDPN, January 2023

As part of our new awareness efforts, NBDPN would like to recognize that systemic barriers can create gaps in access to the recommended care in our prevention tips. So, we aim to reinforce these prevention tips by sparking more actions and conversations in your local communities to identify, or build, more resources for successful pregnancies! Importantly, we would like to clarify that this theme is focused on the preparation stages of your journey into parenthood. Many of these conditions extend across the lifespan.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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