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Hot Topics of the Day|PHGKB
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09/18/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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SARS-CoV-2 Nasopharyngeal Swab Testing—False-Negative Results From a Pervasive Anatomical Misconception
TS Higgins et al, JAMA Oto Laryngo, September 17, 2020

A qualitative real-time polymerase chain reaction of nasopharyngeal secretions is the criterion standard for identifying respiratory viruses, including severe acute respiratory syndrome coronavirus SARS-CoV-2).However, major concerns have been raised regarding the rates of false-negative results in community testing locations.

Severe COVID-19 Infections—Knowledge Gained and Remaining Questions
LDJ Bos et al, JAMA Internal Medicine, September 18, 2020

Despite rapid progress, much remains to be learned about severe COVID-19. For example, the pathophysiological pathways in COVID-19 that result in ARDS and how these relate to the classical understanding of ARDS are uncertain.

Predictors of characteristics associated with negative SARS-CoV-2 PCR test despite proven disease and association with treatment and outcomes. The COVID-19 RT-PCR Study.
JB Lascarou et al, MEDRXIV, September 15, 2020

Leveraging pathogen sequence and contact tracing data to enhance vaccine trials in emerging epidemics
R Kahn et al, MEDRXIV, September 16, 2020

Clinical course and potential predictive factors for pneumonia of adult patients with Coronavirus Disease 2019 (COVID-19): a retrospective observational analysis of 193 confirmed cases in Thailand
WA Pongpirul et al, MEDRXIV, September 16, 2020

Internet search patterns reveal clinical course of COVID-19 disease progression and pandemic spread across 32 countries
T Lu et al, MEDRXIV, September 16, 2020

Genomic epidemiology of a densely sampled COVID19 outbreak in China
L Geidelberg et al, MEDRXIV, September 16, 2020

Comparison of media and standards for SARS-CoV-2 RT-qPCR without prior RNA preparation
KB Ragan et al, MEDRXIV, September 17, 2020

Estimating Risk of Mechanical Ventilation and Mortality Among Adult COVID-19 patients Admitted to Mass General Brigham: The VICE and DICE Scores
CJ Nicholson et al, MEDRXIV, September 17, 2020

Optimizing direct RT-LAMP to detect transmissible SARS-CoV-2 from primary nasopharyngeal swab and saliva patient samples
DM Dudley et al, MEDRXIV, September 17, 2020

Quantifying SARS-CoV-2 infection risk within the Google/Apple exposure notification framework to inform quarantine recommendations
AM Wilson et al, MEDRXIV, September 14, 2020

Implementing Cancer Genomics in State Health Agencies: Mapping Activities to an Implementation Science Outcome Framework.
Green Ridgely Fisk et al. Public health genomics 2020 Sep 1-12

We identified state health agency activities addressing hereditary breast and ovarian cancer and Lynch syndrome by reviewing project narratives from Centers for Disease Control and Prevention Cancer Genomics Program funding recipients, leading discussions with state health agencies, and conducting an environmental scan.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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