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Hot Topics of the Day|PHGKB
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08/21/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Modeling Contact Tracing Strategies for COVID-19 in the Context of Relaxed Physical Distancing Measures
A Bilinski et al JAMA Network Open, August 21, 2020

To support efforts to control COVID-19, contact tracing must be implemented alongside prompt and extensive community case detection, and a high proportion of contacts must be reached. Our estimates imply that contact tracing could support partial relaxation of physical distancing measures but not a full return to levels of contact before lockdown.

AI Methods Make COVID-19 Forecasting More Local
S Fernandez, Nexgov, August 10, 2020

Artificial intelligence techniques have inspired a new COVID-19 forecasting model provide timely information at a more localized level. The researchers say that officials and anyone in the public can use in their decision-making processes. “We are all overwhelmed by the data, most of which is provided at national and state levels.”

Physics-informed machine learning for the COVID-19 pandemic: Adherence to social distancing and short-term predictions for eight countries
GD Bamparis et al, ARXIV, August 20, 2020

Image quality assessment for closed-loop computer-assisted lung ultrasound
ZMC Baum et al, ARXIV, August 20, 2020

Autonomous Social Distancing in Urban Environments using a Quadruped Robot
T Fan et al, ARXIV, AUgust 20, 2020

A Data-Efficient Deep Learning Based Smartphone Application For Detection Of Pulmonary Diseases Using Chest X-rays
S Shalu et al, ARXIV, August 19, 2020

Considerations, Good Practices, Risks and Pitfalls in Developing AI Solutions Against COVID-19
A Luccioni et al, ARXIV, AUgust 13, 2020

A review on the mobile applications developed for COVID-19: An exploratory analysis
MN Islam et al, ARXIV, August 20, 2020

Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand
JL Geoghegan et al, MEDRXIV, AUgust 20, 2020

We generated 649 SARS-CoV-2 genome sequences from infected patients in New Zealand representing 56% of all confirmed cases in this time period. The proportion of D614G variants in the virus spike protein increased over time due to an increase in their importation frequency, rather than selection within New Zealand. These data also helped to quantify the effectiveness of public health interventions.

Is "No test is better than a bad test"? Impact of diagnostic uncertainty in mass testing on the spread of Covid-19
N Gray et al, MEDRXIV, August 20, 2020

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: monitoring county level vulnerability
SW Marvel et al, MEDRXIV, August 20, 2020

We integrated baseline data on relevant community vulnerabilities with dynamic data on local infection rates and interventions into a Pandemic Vulnerability Index (PVI). The PVI presents a visual synthesis of county-level vulnerability indicators that can be compared in a regional, state, or nationwide context. We describe use of the PVI, supporting epidemiological modeling and machine-learning forecasts, and deployment of an interactive, web Dashboard.

Molecules in the blood of older people promote cancer spread
H Wang et al, Nature News, August 19, 2020

A molecule produced by the metabolism of proteins and fats has been found to accumulate in the blood of older people, and to endow cancer cells with the ability to spread from one site in the body to others.

Health-care practitioners’ preferences for the return of secondary findings from next-generation sequencing: a discrete choice experiment
S Jiang et al, Genetics in Medicine, AUgust 21, 2020

Health-care practitioners’ (HCPs) preferences for returning secondary findings (SFs) will influence guideline compliance, shared decision-making, and patient health outcomes. This study aimed to estimate HCPs’ preferences and willingness to support the return (WTSR) of SFs in Canada.

LIVING WITH LYNCH 2020- Virtual Patient Workshop
Alive and Kicking and Colon Cancer Foundation Webinar October 9, 2020

Join for unique patient perspectives and the latest information from experts on Lynch syndrome.

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
AC Fahed et al, Nature Communications, August 20, 2020

We study 80,928 individuals to examine whether polygenic background can modify penetrance of disease in tier 1 genomic conditions — familial hypercholesterolemia, hereditary breast and ovarian cancer, and Lynch syndrome. Among carriers of a monogenic risk variant, we estimate substantial gradients in disease risk based on polygenic background — the probability of disease by age 75 years ranged from 17% to 78% for coronary artery disease, 13% to 76% for breast cancer, and 11% to 80% for colon cancer.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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