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Hot Topics of the Day|PHGKB
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08/07/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Inflammasome activation in COVID-19 patients
TS Rodrigues et al, MEDRXIV July 6, 2020

Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand
JL Geoghegan et al, MEDRXIV, August 7, 2020

Phylogenetic analysis of SARS-CoV-2 data is difficult
B Morel et al, BIORXIV, August 6, 2020

Pathogenetic Perspective of Missense Mutations of ORF3a Protein of SARS-CoV2
SS Hassan et al, August 6, 2020

Fast, cheap tests could enable safer reopening
RF Service, Science, August 7, 2020

Modelling the impact of testing, contact tracing and household quarantine on second waves of COVID-19
A Aleta et al, Nature Human Behavior, August 5, 2020

We integrate anonymized, geolocalized mobility data with census and demographic data to build a detailed model of transmission in Boston. We find that strict social distancing followed by testing, contact-tracing and quarantine could keep the disease within capacity of healthcare system while enabling the reopening of economic activities.

Using a real-world network to model localized COVID-19 control strategies
JA Firth et al, Nature Medicine, August 7, 2020

It remains unclear how real-world social networks could influence the effectiveness and efficiency of such approaches. To address this issue, we simulated control strategies for SARS-CoV-2 transmission in a real-world social network generated from high-resolution GPS data.

Smart Pooling: AI-powered COVID-19 testing
M Escobar et al, MEDRXIV<,August 5, 2020

Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR
I Smyralcki et al, MEDRXIV, August 5, 2020

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis
MG Ferrarini et al, BIORXIV, August 5, 2020

A distinct innate immune signature marks progression from mild to severe COVID-19
S Chevrier et al, BIORXIV, August 4, 2020

Mining Google and Apple mobility data: Twenty-one shades of European social distancing measures for COVID-19
G Cacciapaglia et al, ARXIV< August 6, 2020

Genetic variability in the expression of the SARS-CoV-2 host cell entry factors across populations
LO Fernandez et al, Genes and Immunity, August 6, 2020

We devised a quantitative measure to estimate genetic determinants of ACE2 and TMPRSS2 expression and applied this measure to >2500 individuals. Our data show significant variability in genetic determinants of expression among individuals and between populations, and indicate a predisposition for lower expression levels in African populations.

Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patients With SARS-CoV-2 Infection in a Community Treatment Center in the Republic of Korea
S Lee et al, JAMA Internal Medicine, August 6, 2020

In this cohort study of 303 patients with SARS-CoV-2 infection isolated in a community treatment center in Korea, 110 (36.3%) were asymptomatic at the time of isolation and 21 (19.1%) developed symptoms during isolation. The threshold values of reverse transcription–polymerase chain reaction in asymptomatic patients were similar to those in symptomatic patients.

Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians
M Wang et al, JACC, August 6, 2020

Genome-wide polygenic scores (GPS) integrate information from many common DNA variants into a single number. Because rates of coronary artery disease (CAD) are substantially higher among South Asians, a GPS to identify high-risk individuals may be particularly useful in this population.

Averting hunger in sub-Saharan Africa requires data and synthesis
J Porciello et al, Nature, August 5, 2020

As the United Nations warns of famine on a scale not seen in 50 years, researchers must help to build agile, inclusive data collection and analysis to inform agricultural policy.

Current Perspective on Age-Related Macular Degeneration
U Chakravarty et al, JAMA, August 6, 2020

Impressive progress in the understanding of age-related macular degeneration has been made in the last few decades. In spite of strong genetic associations, genetic testing is not recommended because there is no consistent evidence of benefit to the individual.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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