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Hot Topics of the Day|PHGKB
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07/07/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

A one-step, one-tube real-time RT-PCR based assay with an automated analysis for detection of SARS-CoV-2
B Dharavath et al, Cell, July 7, 2020

We developed a rapid and accurate one-step multiplex TaqMan probe-based real-time RT-PCR assay, Our assay could detect to a limit of 15 copies of SARS-CoV-2 transcripts—based on experiments performed by spiking total human RNA with in vitro synthesized viral transcripts. The accuracy of the assay was found to be 100% sensitive and 100% specific.

COVID-19 in Latin America: Contrasting phylodynamic inference with epidemiological surveillance. (Molecular epidemiology of COVID-19 in Latin America)
DM Rojas-Gallardo et al, MEDRXIV, July 6, 2020

Sample Pooling as an efficient strategy for SARS-COV-2 RT-PCR screening: a multicenter study in Spain
A de Salazar et al, MEDRXIV, July 6, 2020

Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity
A Graudenzi et al, BIORXIV, July 6, 2020

Gene Expression Network Analysis Provides Potential Targets Against SARS-CoV-2
AI Hernandez et al, BIORXIV, July 6, 2020

Comparison of three TaqMan Real-Time Reverse Transcription-PCR assays in detecting SARS-CoV-2
Y Xiao et al, BIORXIV, July 6, 2020

A Survey on Applications of Artificial Intelligence in Fighting Against COVID-19
J Chen et al, ARXIV, July 4, 2020

A guide to R — the pandemic’s misunderstood metric- What the reproduction number can and can’t tell us about managing COVID-19.
D Adam, Nature News, July 3, 2020

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper
A Dasari et al, Nature Rev Clin Oncol, July 6, 2020

The panel focused on four key areas in which ctDNA has the potential to change clinical practice, including the detection of minimal residual disease, the management of patients with rectal cancer, monitoring responses to therapy, and tracking clonal dynamics in response to targeted therapies and other systemic treatments.

Strategies to Identify and Care for Individuals with Inherited Cancer Syndromes
NCI Webinar, July 30, 2020 Brand

Focused on health care delivery and identifying best practices for case ascertainment and follow-up care in inherited cancer syndromes, NCI seeks to improve sustainable implementation of care delivery models. This webinar discusses the hereditary cancers Cancer Moonshot effort, research and perspective from a current grantee, and directions for future work.

Don’t ask if artificial intelligence is good or fair, ask how it shifts power
P Kalluri, Nature News, July 7, 2020

Researchers in AI overwhelmingly focus on providing highly accurate information to decision makers. Remarkably little research focuses on serving data subjects. What’s needed are ways for these people to investigate AI, to contest it, to influence it or to even dismantle it.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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