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Hot Topics of the Day|PHGKB
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06/28/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Clinical, Pathology, Genetic, and Molecular Features of Colorectal Tumors in Adolescents and Adults 25 Years or Younger.
de Voer Richarda M et al. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Jun

We found features of CRCs in adolescents or young adults to differ from those of patients older than 60 years. In 39% of patients a genetic tumor-risk syndrome was identified. This suggests new strategies for clinical management. Performing genetic analyses for every individual diagnosed with CRC at age 25 years or younger would aid in this optimization.

Genetic drug target validation using Mendelian randomisation
AF Schmidt et al, Nature Comms, June 26, 2020

Proteins are typically the proximal effectors of biological processes encoded in the genome. Moreover, proteins are the targets of most medicines, so mendelian randomization studies of drug targets are becoming a fundamental tool in drug development. To enable such studies, we introduce an analytical framework for evaluating the robustness of analyses.

NHGRI commemorates 20th anniversary of White House event announcing draft human genome sequence
NHGRI, June 26, 2020 Brand

The signature goal of the Human Genome Project (HGP) was to generate a sequence of the three billion letters (A, C, G and T) in the human DNA instruction book. The multidisciplinary, international consortium worked tirelessly towards this goal, recognizing the incredible resource it would provide for the biomedical research enterprise.

Saliva sampling is an excellent option to increase the number of SARS CoV2 diagnostic tests in settings with supplies shortages
JM Contreras et al, BIORXIV, June 27, 2020

Evaluating Data Types-A Guide for Decision Makers using Data to Understand the Extent and Spread of COVID-
NASEM, June 2020

National Academies Offers Guidance to Decision-Makers on Evaluating COVID-19 Data
J Stephenson, JAMA Health Forum, June 25, 2020

An expert consultation says that decision-makers leading the response to COVID-19 should consider specific criteria when evaluating numbers of confirmed cases, hospitalizations, excess deaths, and other data to make COVID-19–related policy decisions, such as restricting or allowing public gatherings or mandating the wearing of face masks in public places.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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