Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

06/25/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

Redundant meta-analyses are common in genetic epidemiology.
Sigurdson Matthew et al. Journal of clinical epidemiology 2020 Jun

The massive growth in the publication of meta-analyses may cause redundancy and wasted efforts. We performed a meta-epidemiologic study to evaluate the extent of potential redundancy in published meta-analyses in genetic epidemiology.

Genetic Diversity and Genomic Epidemiology of SARS-COV-2 in Morocco
B Badaoui et al, BIORXIV, June 23, 2020

Detailed phylogenetic analysis of SARS-CoV-2 reveals latent capacity to bind human ACE2 receptor
E Britnell et al, BIORXIV, June 23, 2020

Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2
Y Zhang et al, Nature Communications, June 2020

Amid the COVID-19 pandemic, scientists around the globe have been working resolutely to find therapies to treat patients and avert the spreading of the SARS-CoV-2 virus. In this commentary, we highlight some of the latest studies that provide atomic-resolution structural details imperative for the development of vaccines and antiviral therapeutics.

The composition and capacity of the clinical genetics workforce in high-income countries: a scoping review.
Dragojlovic Nick et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Jun

Our results indicate that there is currently a shortage of genetics providers and that there is a lack of consensus about the appropriate boundaries between the scopes of practice for genetics and nongenetics providers. Results point to strategies that may be used to increase productivity and efficiency, including alternative service delivery models.

Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.
Dapas Matthew et al. PLoS medicine 2020 Jun (6) e1003132

Our results suggest that there are distinct forms of PCOS that are associated with different underlying biological mechanisms. Women with PCOS may be poorly served by being grouped under a single diagnosis because PCOS subtypes may differ in responses to therapy and in long-term outcomes.

Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa
CC John et al, NEJM, June 25, 2020

Among children with sickle cell anemia in sub-Saharan Africa, hydroxyurea with dose escalation had superior clinical efficacy to that of fixed-dose hydroxyurea, with equivalent safety.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP