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Hot Topics of the Day|PHGKB
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06/18/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Genes, Blood Type Tied to Risk of Severe COVID-19
NIH Director's Blog, June 18, 2020 Brand

The analysis identified two places, one on chromosome 3 and covers a cluster of six genes with potentially relevant functions such as a protein known to interact with angiotensin converting enzyme 2 (ACE2). The other association signal popped up on chromosome 9, right over the area of the genome that determines ABO blood type.

Genomewide Association Study of Severe Covid-19 with Respiratory Failure
D Ellinghaus et al, NEJM, June 17, 2020

We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals. We identified a 3p21.31 gene cluster as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and confirmed a potential involvement of the ABO blood-group system.

COVID-19 Update: Blood Type Link, Comorbidities and Mortality
M McNamara, Medscape, June 17, 2020

COVID-19 and Blood Type: 'May Be Something Here'- Evidence is mounting that people with Type A blood could be at higher risk for COVID-19 infection and mortality, according to three recent studies. At the same time, Type O blood may be somewhat protective.

Digital Contact Tracing Using IP Colocation
M Malloy et al, ARXIV, June 16, 2020

Genome-wide mapping of therapeutically-relevant SARS-CoV-2 RNA structures
L Manfredonia et al, BIORXIV, June 15, 2020

Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course
S Tang et al, MEDRXIV, June 17, 2020

FAST: a Flexible, Accurate and Speedy Test Strategy for COVID-19
L Fang et al, MEDRXIV, June 16, 2020

Social determinants of health, data science, and decision-making: Forging a transdisciplinary synthesis
S Galea et al, PLOS Medicine, June 2020

It is time to bring about a transdisciplinary synthesis of different streams. The social determinants of health represent an agenda for action to improve health that can be enhanced by a serious engagement with the role that data and technology are beginning to play in improving population health.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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