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Hot Topics of the Day|PHGKB
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06/14/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

SARS-CoV-2 sequence typing, evolution and signatures of selection using CoVa, a Python-based command-line utility
F Ali et al, BIORXIV, June 12, 2020

Broad-Range Virus Detection and Discovery Using Microfluidic PCR Coupled with High-throughput Sequencing
Y Tao et al BIORXIV, June 12, 2020

The impact of super-spreaders in COVID-19: mapping genome variation worldwide
A Gomez-Carballa et al, BIORXIV, June 12, 2020

Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression
C Wu et al, BIORXIV, June 12, 2020

Machine Learning Maps Research Needs in COVID-19 Literature
AL Doanvo et al, BIORXIV, June 12, 2020

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19
G Carissimo et al, BIORXIV, June 12, 2020

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity
L Zhang et al, BIORXIV, June 12, 2020

Profiling the positive detection rate of SARS-CoV-2 using polymerase chain reaction in different types of clinical specimens: a systematic review and meta-analysis
GM Bwire et al, MEDRXIV, June 12, 2020

Evolution and epidemic spread of SARS-CoV-2 in Brazil
D da Silva Candido et al, MEDRXIV, June 12, 2020

Detection of SARS-CoV-2 in wastewater in Japan by multiple molecular assays-implication for wastewater-based epidemiology (WBE)
A Hata et al, MEDRXIV, June 12, 2020

An imperfect tool: COVID-19 'test & trace' success relies on minimising the impact of false negatives and continuation of physical distancing.
EL Davis et al, MEDRXIV, June 13, 2020

Initial Whole Genome Sequencing and Analysis of the Host Genetic Contribution to COVID-19 Severity and Susceptibility
F Wang et al, MEDRXIV, June 13, 2020

This is the first host genetic study in China by deeply sequencing the 332 COVID-19 patients categorized by varying levels of severity. Gene loci associated with severity is located in TMEM189-UBE2V1 involved in the IL-1 signaling pathway. The p.Val197Met missense variant that affects the stability of the TMPRSS2 protein displays a decreasing allele frequency.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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