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Hot Topics of the Day|PHGKB
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06/13/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

ation could make coronavirus more infectious, study suggests
M Fox, CNN, June 12, 2020

Rapid point of care nucleic acid testing for SARS-CoV-2 in hospitalised patients: a clinical trial and implementation study
DA Collier et al, MEDRXIV, June 11, 2020

Population-scale Longitudinal Mapping of COVID-19 Symptoms, Behavior, and Testing Identifies Contributors to Continued Disease Spread in the United States
WE Allen et al, MEDRXIV, June 11, 2020

V-pipe: a computational pipeline for assessing viral genetic diversity from high-throughput sequencing data
SP Cespedes et al, BIORXIV, June 11, 2020

Differential expression of COVID-19-related genes in European Americans and African Americans
U Singh et al, BIORXIV, June 10, 2020

Global cataloguing of variations in untranslated regions of viral genome and prediction of key host RNA binding protein-microRNA interactions modulating genome stability in SARS-CoV2
P Mukherje et al, BIORXIV, June 12, 2020

Predicting inhibitors for SARS-CoV-2 RNA-dependent RNA polymerase using machine learning and virtual screening
R Cozac et al, ARXIV, June 9, 2020

Aspirin for Lynch syndrome: a legacy of prevention
MB Yurgelun et al, The Lancet, June 13, 2020

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial
J Burn et al, The Lancet June 13, 2020

In the double-blind, randomized CAPP2 trial, 861 patients from 43 international centres worldwide (707 [82%] from Europe, 112 [13%] from Australasia, 38 [4%] from Africa, and four [<1%] from The Americas) with Lynch syndrome were randomly assigned to receive 600 mg aspirin daily or placebo. Cancer outcomes were monitored for at least 10 years from recruitment.

The limited use of US residual newborn screening dried bloodspots for health disparity research
NO Riches et al, GIM, June 11, 2020

State-run newborn screening programs screen nearly all babies born in the United States at the time of delivery. After newborn screening has been completed, some states store the residual dried bloodspots. It is unknown how they have been used to address health disparities–related research.

Key steps for effective breast cancer prevention
KL Britt et al, Nat Rev Cancer, June 11, 2020

We can estimate a woman’s breast cancer risk using validated risk assessment models. Models are likely to improve over time, particularly with inclusion of polygenic risk and mammographic density. Evidence-based risk-reducing medications are recommended by professional health bodies; however, widespread implementation of these has proven challenging.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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