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Hot Topics of the Day|PHGKB
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06/06/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Sex hormones signal why virus hits men harder
S Wadman, Science, June 5, 2020

COVID-19 diagnostics in context
R Weissleder et al, Science Trans Med, June 3, 2020

The coronavirus disease 2019 (COVID-19) pandemic has highlighted the need for different types of diagnostics, comparative validation of new tests, faster approval by federal agencies, and rapid production of test kits to meet global demands. In this Perspective, we discuss the utility and challenges of current diagnostics for COVID-19.

COVID-19’s Impact on Genetics at One Medical Center in New York
EM Pereira et al, Genetics in Medicine, June 5, 2020

Due to the unique challenges of social distancing, attempting to keep workforce and patients safe, there have been rapid changes in delivering medical care across the country. We provide this commentary on challenges faced and lessons learned at an academic medical center by modifying how we provide genetic care to a diverse patient population.

The biggest mystery: what it will take to trace the coronavirus source
D Cyranoski, Nature News, June 5, 2020

Impact of Comorbidities on SARS-CoV-2 Viral Entry-Related Genes
JD Breidenbach et al, BIORXIV, June 4, 2020

Inhibition of Corona virus spike protein binding to ACE2
E Peter et al, BIORXIV, June 4, 2020

Analyzing hCov genome sequences: Applying Machine Intelligence and beyond
S Sawmya et al, BIORXIV, June 3, 2020

Pediatric inflammatory syndrome temporally related to covid-19
BMJ Editorial, June 2020

Inflammasome genetics and complex diseases: a comprehensive review
FP Fernandes et al, EJHG June 5, 2020

Several genetic variants in inflammasome components have been associated with common pathologies in the general population, such as autoimmune disorders, cardiovascular diseases, obesity and associated metabolic syndrome, neurodegenerative diseases, and cancer.

The Project Baseline Health Study: a step towards a broader mission to map human health
K Arges et al, NPJ Digital Medicine, June 5, 2020

The PBHS will contribute to precision health and medicine by integrating state of the art testing, longitudinal monitoring and participant engagement, and by contributing to the development of an improved platform for data sharing and analysis

MutSpot: detection of non-coding mutation hotspots in cancer genomes
YA Guo et al, NPJ Genomic Medicine, June 5, 2020

Recurrence and clustering of somatic mutations (hotspots) in cancer genomes may indicate positive selection and involvement in tumorigenesis. MutSpot performs genome-wide inference of mutation hotspots in non-coding and regulatory DNA of cancer genomes. MutSpot performs feature selection across hundreds of epigenetic and sequence features.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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