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Hot Topics of the Day|PHGKB
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06/03/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis
D Ellinghaus et al, MEDRXIV, June 2, 2020

G6PD variant distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19
J Da Rocha et al, MEDRXIV, June 2, 2020

Development and Evaluation of an AI System for COVID-19 Diagnosis
C Jin et al, MEDRXIV, June 2, 2020

Rapid Epidemiological Analysis of Comorbidities and Treatments as risk factors for COVID-19 in Scotland (REACT-SCOT): a population-based case-control study
PM McKeigue et al, MEDRXIV, June 2, 2020

Development and Validation of a Survival Calculator for Hospitalized Patients with COVID-19
TJ Levy et al, MEDRXIV< June 2, 2020

GenOMICC study on COVID-19 patients
Genomics England, June 2020

Genomics England is working with the NHS to deliver whole genome sequencing of up to 20,000 people who have been severely affected by COVID-19 – requiring intensive care – and 15,000 people who had mild symptoms. This study aims to find out whether there are genetic factors for some people experiencing severe symptoms.

The CALL score for predicting outcomes in patients with COVID-19.
Grifoni Elisa et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020 May

Thousands of people will help scientists to track the long-term health effects of the coronavirus crisis - Cohort studies that follow populations over years have quickly pivoted to trace the pandemic’s physical, mental and social consequences.
A Abbot, Nature News, June 1, 2020

COVID-19: review of disparities in risks and outcomes - Review into how different factors have affected COVID-19 risk and outcomes.
Public Health England, June 2, 2020

This is a descriptive review of surveillance data on disparities in the risk and outcomes from COVID-19. The review looked at different factors including: age and sex, where people live, deprivation, ethnicity, people’s occupation, care home residence. The findings are based on the latest surveillance data available and from links to wider health data sets.

The need for privacy with public digital contact tracing during the COVID-19 pandemic
Y Bengio et al, Lancet Digital Health, June 2, 2020

Despite their potential advantages, most of the applications in use or under consideration have an impact on individual privacy that democratic societies would normally consider to be unacceptably high. In a free and democratic society, there are major concerns regarding privacy.

Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study
KX Lim et al, PLOS Medicine, June 1, 2020

We used data from UK Biobank participants to investigate 24 potential individual risk factors for self-harm.Out of these 24 risk factors, major depressive disorder, attention-deficit hyperactivity disorder and schizophrenia appeared to be the most plausible causal risk factors for self-harm.?

Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis.
Turk Margaret A et al. Disability and health journal 2020 May 100942

People with intellectual and developmental disabilities had higher prevalence of specific comorbidities associated with poorer COVID-19 outcomes. Distinct age-related differences in COVID-19 trends were present among those with IDD, with a higher concentration of COVID-19 cases at younger ages.

Germline Testing In Advanced Cancer Can Lead to Targeted Tx
R Nelson, Medscape, June 2, 2020

From 7% to nearly 9% of patients with advanced cancer were found to harbor a germline variant with targeted therapeutic actionability in the first study of its kind. The study involved 11,975 patients with various tumor types. All the patients underwent germline genetic testing from 2015 to 2019.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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