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Hot Topics of the Day|PHGKB
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05/23/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

NCI COVID-19 in Cancer Patients Study (NCCAPS)
NCI, May 2020 Brand

Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach
CM Clase et al, Ann Int Med, May 22, 2020

Pooling nasopharyngeal swab specimens to increase testing capacity for SARS-CoV-2
C Anderson et al, BIORXIV, May 22, 2020

Improved measurement of racial/ethnic disparities in COVID-19 mortality in the United States
JR Goldstein et al, MEDRXIV, May 23, 2020

A score-based risk model for predicting severe COVID-19 infection as a key component of lockdown exit strategy
N Dagan et al, MEDRXIV, May 23, 2020

Remdesivir for the Treatment of Covid-19 — Preliminary Report
JH Beigel et al, NEJM, May 22, 2020

Preliminary results from the 1059 patients (538 assigned to remdesivir and 521 to placebo) with data available after randomization indicated that those who received remdesivir had a median recovery time of 11 days, as compared with 15 days in those who received placebo (rate ratio for recovery, 1.32; 95% CI, 1.12 to 1.55; P<0.001).

Diagnosing hereditary cancer predisposition in men with prostate cancer.
Pritzlaff Mary et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 May

A yield of 9.4–12.1% was observed among men with no prior genetic testing. In this group, the positive rate of BRCA1 and BRCA2 was 4.6%; the positive rate for the mismatch repair genes was 2.8%. Increasing Gleason score, personal history, and family history were predictors of positive results.

Automated screening of sickle cells using a smartphone-based microscope and deep learning
K de Haan et al, NPJ Digital Health, May 22, 2020

We present a deep learning framework which can perform automatic screening of sickle cells in blood smears using a smartphone microscope. We blindly tested this mobile sickle cell detection method using blood smears from 96 unique patients that were imaged by our smartphone microscope, and achieved ~98% accuracy, with an area-under-the-curve of 0.998.

Genetic Counseling in the Time of COVID-19
K Bruder et al, CDC Blog, May 22, 2020 Brand

Telehealth has the potential to improve access to services, which is a major benefit in a field where there is a high and growing demand for genetics services. Many genetic counselors consider telehealth to be more convenient than traditional in-person service delivery due to reduced travel times and wait times for patients


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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