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Hot Topics of the Day|PHGKB
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05/18/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

COVID-19 and the Need for a National Health Information Technology Infrastructure
DF Sittig et al, JAMA, May 18, 2020

The need for timely, accurate, and reliable data about the health of the US population has never been greater. Critical questions include: (1) how many individuals test positive and how many are affected by the disease in a given geographic area; (2) what are the age and race of these individuals; (3) how many people sought care, and many more.

Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)- An Unprecedented Partnership for Unprecedented Times
FS Collins et al, JAMA< May 18, 2020

Critical discussions culminated in a decision to form a public-private partnership to focus on speeding the development and deployment of therapeutics and vaccines for COVID-19. The group assembled 4 working groups to focus on preclinical therapeutics, clinical therapeutics, clinical trial capacity, and vaccines.

CRISPR tool scales up to interrogate a huge line-up of viral suspects
GA Storch, Nature News, May 18, 2020

Rapid, reliable identification of an unknown viral infection is challenging. Use of CRISPR technology can simultaneously detect nucleic acids of many viruses and pinpoint specific ones, such as the virus that causes COVID-19.

The sprint to solve coronavirus protein structures — and disarm them with drugs- Stopping the pandemic could rely on breakneck efforts to visualize SARS-CoV-2 proteins and use them to design drugs and vaccines.
M Scudellari, Nature News, May 15,2020

Saliva is less sensitive than nasopharyngeal swabs for COVID-19 detection in the community setting
D Becker et al, MEDRXIV, May 17,2020

A non-competing pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
Y Wu et al, MEDRXIV, May 17,2020

Why the Coronavirus Hits Kids and Adults So Differently- COVID-19 is much less severe in children, and it could have to do with a child’s still-developing immune system.
S Zhang, the Atlantic, May 15, 2020

The therapeutic potential of exosomes
J Madhusoodanan, Nature Outlook, May 13, 2020

Extracellular vesicles released in response to cigarette smoke might trigger chronic obstructive pulmonary disease, but engineered versions could be a treatment.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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