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Hot Topics of the Day|PHGKB
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05/17/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden.
Qing Tao et al. Nature communications 2020 May (1) 2438

Assessment of the Value of Tumor Variation Profiling Perceived by Patients With Cancer
P Butow et al, JAMA Network Open, May 14, 2020

In this survey study of 777 patients with advanced cancer, 689 individuals (89%) indicated that they would have tumor molecular profiling for as little as a 1% actionable return rate, but fewer were willing to pay for it.

Implications of SARS-CoV-2 mutations for genomic RNA structure and host microRNA targeting
AH Rad et al BIORXIV, May 16, 2020

A Computational Toolset for Rapid Identification of SARS-CoV-2, other Viruses, and Microorganisms from Sequencing Data
S Chen et al, BIORXIV, May 16, 2020

COVID-19 in Spain: age, Interleukin-6, C Reactive Protein and lymphocytes as key clues from a multicentre retrospective study
A Jurado et al, MEDRXIV, May 16, 2020

Correlation between PCR Examination Rate among the Population and the Containment of Pandemic of COVID-19
M Sonoo et al, MEDRXIV, May 16, 2020

Derivation and validation of a prognostic model for predicting in-hospital mortality in patients admitted with COVID-19 in Wuhan, China: the PLANS (Platelet Lymphocyte Age Neutrophil Sex) model
J Li et al, MEDRXIV, May 16, 2020

Tracking the COVID-19 pandemic in Australia using genomics
T Seamann et al, MEDRXIV, May 16, 2020

Sequenced samples from Australia were representative of the global diversity of SARS-CoV-2, consistent with epidemiological findings of multiple importations and limited onward transmission. In total, 76 distinct genomic clusters were identified; these included large clusters and minimal intra-patient SARS-CoV-2 genomic diversity.

DERIVATION OF A SCORE TO PREDICT ADMISSION TO INTENSIVE CARE UNIT IN PATIENTS WITH COVID-19: THE ABC-GOALS SCORE
JM Mejia-Vilet et al, MEDRXIV, May 16, 2020

THE MUC5B PROMOTOR POLYMORPHISM ASSOCIATES WITH SEVERE COVID-19
CHM van Moorsel et al, MEDRX, May 16, 2020

The Evaluation of Deep Neural Networks and X-Ray as a Practical Alternative for Diagnosis and Management of COVID-19
M EL-Gendi et al, MEDRXIV, May 16, 2020

A comprehensive germline variant and expression analyses of ACE2, TMPRSS2 and SARS-CoV-2 activator FURIN genes from the Middle East: Combating SARS-CoV-2 with precision medicine
F Al-Mulla et al, BIORXIV, May 16, 2020

Clinical Application of Computational Methods in Precision Oncology- A Review
OA Panagiotou et al, JAMA Oncology, May 14, 2020

This review evaluates best practices for enabling responsible use of computational methods in the oncology clinic: data quality, data diversity, risk-based software as a medical device regulatory approval pathway, computational reproducibility, face validity, prospective clinical utility trials, training, and multidisciplinary boards.

COVID-19 Disrupting Care for Nine of 10 People with Rare Condition
Global Genes, May 2020

As hospitals have curtailed services to focus on responding to the pandemic and minimizing the risk of infecting people, the survey found that six in 10 rare disease patients said they did not have access to medical therapies at home or at the hospital anymore, such as infusions, chemotherapy, and hormonal treatment.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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