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Hot Topics of the Day|PHGKB
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04/28/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on death and severity of disease in patients with coronavirus disease 2019 (COVID-19): A meta-analysis
S Ghosal et al, MEDRXIV, April 28, 2020

Five studies were eligible for meta-analysis. These included 308 patients on ACEi/ARB, and 1172 not on ACEi/ARB. Compared to patients with COVID-19 not on ACEi/ARB, there was a statistically significant 44% reduction in odds of developing severe disease (OR: 0.56), and 62% reduction in odds of death (OR: 0.38) in those on ACEi/ARB.

Whose coronavirus strategy worked best? Scientists hunt most effective policies-Researchers sift through data to compare nations’ vastly different containment measures.
E Gibney, Nature, April 27, 2020

Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract
JC Smith, et al, BIORXIV, April 26, 2020

Emergence of multiple variants of SARS-CoV-2 with signature structural changes
D Bhowmick et al, BIORXIV, April 27, 2020

Early detection of superspreaders by mass group pool testing can mitigate COVID-19 pandemic
MB Gongalsky, MEDRXIV, April 27, 2020

Metropolitan Wastewater Analysis for COVID-19 Epidemiological Surveillance
W Randazzo et al, MEDRXIV, April 27, 2020

We have used RT-qPCR for SARS-CoV-2 detection in metropolitan wastewaters samples collected during the earliest stages of the epidemic in Valencia, Spain. Our results strongly suggest that the virus was undergoing community transmission earlier than previously believed, and show that wastewater analysis is a sensitive and cost-effective strategy for surveillance.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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