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Hot Topics of the Day|PHGKB
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04/13/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Biophysical characterization of the SARS-CoV2 spike protein binding with the ACE2 receptor explains increased COVID-19 pathogenesis
R Chowdhury et al, BIORXIV, April 12, 2020

Insights on early mutational events in SARS-CoV-2 virus reveal founder effects across geographical regions
C Farkas et al, BIORXIV, April 12, 2020

We describe early mutational events across samples from publicly available sequences. Of 30 high quality datasets, 27 datasets (90%) contain at least a single founder mutation and most of the variants are missense (over 63%). Five-point mutations with clonal (founder) effect were found in USA sequencing samples.

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)- A Review
JAM Sanders et al, JAMA, April 13, 2020

No proven effective therapies for this virus currently exist. The rapidly expanding knowledge regarding SARS-CoV-2 virology provides a significant number of potential drug targets. The most promising therapy is remdesivir. Remdesivir has potent in vitro activity against SARS-CoV-2, but it is currently is being tested in ongoing randomized trials.

Who Is Immune to the Coronavirus? About this question, too, decisions with great consequences are being made, as they must be, based on only glimmers of data.
M Lipsitch, NY Times, April 13, 2020

How digital data collection can help track covid-19 cases in real time
E Topol, Washington Post, April 10, 2020

No other method provides continuous, real-time monitoring of people besides digital technologies. To contemplate reopening our economy without putting public health at unnecessary risk, we need a practical strategy that exploits our digital infrastructure.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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