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Hot Topics of the Day|PHGKB
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04/11/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Introductions and early spread of SARS-CoV-2 in the New York City area
ASG Reiche et al, MedRXIV, April 11, 2020

To identify the early events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced COVID19 in patients seeking care at one of the hospitals of Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV2 genomes indicates multiple, independent but isolated introductions mainly from Europe and other parts of the United States.

Fast SARS-CoV-2 detection by RT-qPCR in preheated nasopharyngeal swab samples
JA Florez et al, MEDRXIV, April 11, 2020

Potential dissemination of epidemics based on Brazilian mobile geolocation data. Part I: Population dynamics and future spreading of infection in the states of Sao Paulo and Rio de Janeiro during the pandemic of COVID-19.
PS Peixoto et al, MEDRXIV, April 11, 2020

Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City
CM Petrilli et al, MEDRXIV, April 11, 2020

Testing the association between blood type and COVID-19 infection, intubation, and death
M Ziets et al, MEDRXIV, April 11, 2020

We used observational healthcare data on 1559 individuals tested for SARS-CoV-2 (682 COV+) with known blood type in the New York Presbyterian hospital system. We found a higher proportion of blood group A and a lower proportion of blood group O among COV+ patients compared to COV-.

Apple and Google Team Up to ‘Contact Trace’ the Coronavirus
J Nicas et al, NY Times, April 10, 2020

NIH begins study to quantify undetected cases of coronavirus infection
NIH, April 10, 2020 Brand

Comparative ACE2 variation and primate COVID-19 risk
AD Melin et al, BIORXIV, April 11, 2020

While infection studies have shown that rhesus macaques exposed to the virus develop COVID-19-like symptoms, the susceptibility of other nonhuman primates is unknown. Here, we show that all apes, including chimpanzees, bonobos, gorillas, and orangutans, and all African and Asian monkeys, exhibit the same set of key amino acid residues as human ACE2

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility
EW Stawiski et al, BIORXIV, April 10, 2020

Using recently reported structural data and a recent S-protein-interacting synthetic mutant map of ACE2, we have identified natural ACE2 variants that are predicted to alter the virus-host interaction and thereby potentially alter host susceptibility. Human ACE2 variants S19P, I21V, E23K, K26R, T27A, N64K, T92I, Q102P and H378R may increase susceptibility.

Assessing the risks of "infodemics" in response to COVID-19 epidemics
R Gallotti et al, MEDRXIV, April 11, 2020

We analyzed more than 100 millions Twitter messages posted worldwide in 64 languages during the epidemic emergency due to SARS-CoV-2 and classified the reliability of news diffused. We found that waves of unreliable and low-quality information anticipate the epidemic ones, exposing entire countries to irrational social behavior and serious threats for public health.

Assessing Digital Phenotyping to Enhance Genetic Studies of Human Diseases.
DeBoever Christopher et al. American journal of human genetics 2020 Apr

We evaluate whether GWAS performed using cases in the UK Biobank ascertained from hospital records, questionnaire responses, and family history implicate similar disease genetics. We show that digital phenotyping and unstructured phenotype data can be combined with structured data to identify cases and improve ability to identify genetic associations.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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