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Hot Topics of the Day|PHGKB
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04/07/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Antisense oligonucleotides for atherosclerotic disease
A Bajaj et al Nature Medicine, April 6, 2020

Novel RNA-targeting antisense therapy is shown to reduce lipoprotein(a) levels in 286 patients with existing atherosclerotic disease by upwards of 80% in a phase 2 clinical trial.

Rapid implementation of mobile technology for real-time epidemiology of COVID-19
DA Drew et al, MEDRXIV, April 6, 2020

The COronavirus Pandemic Epidemiology (COPE) consortium brings together scientists with expertise in big data research and epidemiology to develop a COVID-19 Symptom Tracker mobile application garnering more than 2.25 million users to date. This mobile application offers data on risk factors, herald symptoms, clinical outcomes, and geographical hot spots.

COVID-19 PM2.5: A national study on long-term exposure to air pollution and COVID-19 mortality in the United States
Harvard University, April 6, 2020

Data was collected for approximately 3,000 counties in the United States (98% of the population) up to April 04, 2020. The study found that an increase of only 1 µg/m3 in PM2.5 is associated with a 15% increase in the COVID-19 death rate, 95% confidence interval (CI) (5%, 25%). Results are statistically significant and robust to secondary and sensitivity analyses.

Coronavirus Disease 2019 and Children: What Pediatric Health Care Clinicians Need to Know
SA Rasmussen et al, JAMA Pediatrics, April 5, 2020

While early data suggest that #COVID19 effects on children are less severe than those on adults, yet many questions remain, especially regarding the effects on children with special health care needs.

Management of Hereditary Breast Cancer
ASCO, April 3, 2020

ASCO, American Society for Radiation Oncology, and Society of Surgical Oncology convened an Expert Panel to develop recommendations based on a systematic review. 58 articles met eligibility criteria and formed the evidentiary basis for local therapy recommendations; 6 randomized controlled trials of systemic therapy met eligibility criteria.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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