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Hot Topics of the Day|PHGKB
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04/04/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Addressing Social Determinants of Health- Time for a Polysocial Risk Score
JF Figueroa et al, JAMA, April 3, 2020

The polygenic risk score model offers the field of social determinants of health a possible path forward. Developing an individualized “polysocial risk score” could help predict the risk that varying combinations of social conditions are related to specific health outcomes.

The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease-Insights From Cardiovascular Aging Science
JAMA Cardiology, April 3, 2020

Older individuals have reduced ACE2 expression and upregulation of angiotensin II proinflammatory signaling; the increase in ACE2 levels with ACEI/ARB treatment is more likely to be corrective. We hypothesize that with superimposed COVID-19 disease, vial binding to ACE2 acutely exaggerates this background, predisposing subgroups to greater disease severity.

Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis
EA Coomes et al, MEDRXIV, April 3, 2020

Eight published studies, three pre-prints, and five registered trials were eligible. Meta-analysis of mean IL-6 concentrations demonstrated 2.9-fold higher levels in patients with complicated COVID-19 compared with patients with non-complicated disease .

Using ILI surveillance to estimate state-specific case detection rates and forecast SARS-CoV-2 spread in the United States
JD Silverman et al, MEDRXIV, April 3, 2020

The study shows how publicly available CDC influenza-like illness (ILI) outpatient surveillance data can be repurposed to estimate the detection rate of symptomatic SARS-CoV-2 infections. We find a surge of non-influenza ILI above the seasonal average and show that this surge is correlated with COVID case counts across states.

Could wearables like Apple Watch, Fitbit fitness trackers help detect coronavirus
USA Today, April 3, 2020

Hospitals are grasping for new ways to ease the burden, like incorporating wearables into their efforts to track the progress of the pandemic as it spreads across the country; identify doctors, nurses and others who have contracted the disease as quickly as possible, and monitor patients to make better decisions about who should be hospitalized.

How sewage could reveal true scale of coronavirus outbreak-Wastewater testing could also be used as an early-warning sign if the virus returns.
Nature News, April 3, 2020

More than a dozen research groups worldwide have started analysing wastewater for the new coronavirus as a way to estimate the total number of infections in a community, given that most people will not be tested. The method could also be used to detect the coronavirus if it returns to communities.

The Coronavirus Patients Betrayed by Their Own Immune Systems
New York Times, April 1, 2020

Cytokine storms can overtake people of any age, but some scientists believe that they may explain why healthy young people died during the 1918 pandemic and more recently during the SARS, MERS and H1N1 epidemics. And they may offer clues as to why otherwise healthy young people with coronavirus infection are succumbing to acute respiratory distress syndrome.

Google taps vast trove of location data to aid global effort to combat coronavirus
Washington Post, April 3, 2020

In 131 countries, down to the county level in the United States, Google says government experts will soon be able to see whether people are traveling more or less to grocery stores, pharmacies, parks and other businesses, or generally choosing to heed advice and stay at home. Google is presenting the data as aggregated statistics.

Contribution of macronutrients to obesity: implications for precision nutrition
Nat Rev Endrocrinology, March 31, 2020

the interactions of the genetic make-up and/or microbiota features of a person with specific macronutrient intakes or dietary pattern consumption help to explain individualized responses to macronutrients and food patterns, which might represent key factors for comprehensive precision nutrition recommendations.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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