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Hot Topics of the Day|PHGKB
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03/13/2021

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Vaccine efficacy probable against COVID-19 variants.
Luchsinger Larry L et al. Science (New York, N.Y.) 2021 3 (6534) 1116

Immunity to SARS-CoV-2 variants of concern.
Altmann Daniel M et al. Science (New York, N.Y.) 2021 3 (6534) 1103-1104

Currently, there is concern about reduced vaccine-induced immune protection to emerging variants that have mutations in the spike protein. On page 1152 of this issue, A recent study found reduced induction of neutralizing antibodies from BNT62b2. However, there is likely sufficient efficacy remaining to confer protection from symptomatic disease.

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape.
McCarthy Kevin R et al. Science (New York, N.Y.) 2021 2 (6534) 1139-1142

In the spike glycoprotein, we found that recurrent deletions overcome this slow substitution rate. Deletion variants arise in diverse genetic and geographic backgrounds, transmit efficiently, and are present in novel lineages, including those of current global concern. Deletions in RDRs confer resistance to neutralizing antibodies. By altering stretches of amino acids, deletions appear to accelerate SARS-CoV-2 antigenic evolution and may, more generally, drive adaptive evolution.

Risk for COVID-19 Infection, Hospitalization, and Death By Race/Ethnicity
CDC, March 12, 2021 Brand

Google Trends as a method to predict new COVID-19 cases
T Juric, MEDRXIV, March 12, 2021

Predictive and Causal Analysis of No-Shows for Medical Exams During COVID-19: A Case Study of Breast Imaging in a Nationwide Israeli Health Organization
MO Flato et al, MEDRXIV, March 13, 2021


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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