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Hot Topics of the Day|PHGKB
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02/06/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Recommendations for designing genetic test reports to be understood by patients and non-specialists
GD Farmer et al, EJHG, February 5, 2020

Clinical genomic testing: what matters to key stakeholders?
S Best et al, EJHG, February 5, 2020

Beyond a narrow focus on cost and outcomes, robust evidence of what is valued in genomic medicine is scarce. We gathered views on value from key stakeholders (clinical genomic staff, operational genomic staff and community representatives) in relation to three testing contexts.

Lymelight: forecasting Lyme disease risk using web search data
A Sadilek et al, NPJ Digital Medicine, February 2020

Pan-Cancer Analysis of Whole Genomes
Nature Special, February 2020

Cancer is a disease of the genome, caused by a cell's acquisition of somatic mutations in key cancer genes. The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Project performed whole genome sequencing and integrative analysis on over 2,600 primary cancers and their matching normal tissues across 38 distinct tumor types.

The era of massive cancer sequencing projects has reached a turning point- The future of cancer genomics lies in the clinic
Nature editorial, February 6, 2020

This week, Nature is publishing a suite of papers that sheds new light on the genetic causes of cancer. The results show how far our understanding of cancer has come — and how far we still have to go.

Inter- and intraindividual variability in daily resting heart rate and its associations with age, sex, sleep, BMI, and time of year: Retrospective, longitudinal cohort study of 92,457 adults.
Quer Giorgio et al. PloS one 2020 (2) e0227709

Individuals have a daily resting heart rate (RHR) that is normal for them but can differ from another individual's normal by as much as 70 bpm. Within individuals, RHR was much more consistent over time, with a small but significant seasonal trend, and detectable discrete and infrequent episodes outside their norms


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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