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Hot Topics of the Day|PHGKB
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02/03/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

A pneumonia outbreak associated with a new coronavirus of probable bat origin
P ZHou et al, Nature, February 3, 2020

The epidemic, which started from 12 December 2019, has caused 2,050 laboratory-confirmed infections with 56 fatal cases by 26 January 2020. Full-length genome sequences were obtained from five patients at the early stage of the outbreak. They are almost identical to each other and share 79.5% sequence identify to SARS-CoV.

China coronavirus: labs worldwide scramble to analyse live samples
E Callaway, Nature, January 31, 2020

New coronavirus threat galvanizes scientists
J Cohen, Science, January 2020

Genomic data show that the jump from animals to humans happened recently. An analysis of the first 30 publicly posted sequences shows they differ from each other by no more than seven nucleotides (see graphic, right). Using these differences and presumed mutation rates, several groups have calculated that the virus began to spread around mid-November 2019.

Quantification of Neighborhood-Level Social Determinants of Health in the Continental United States
M Kolak et al, JAMA Network Open, January 2020

In this cross-sectional study of 71?901 census tracts with approximately 312 million persons across the continental United States, multivariate social determinants of health measures were reduced to 4 indices reflecting advantage, isolation, opportunity, and mixed immigrant cohesion and accessibility and were clustered into 7 neighborhood typologies.

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study.
Skrede Ole-Johan et al. Lancet (London, England) 2020 Feb (10221) 350-360

A clinically useful prognostic marker was developed using deep learning allied to digital scanning of conventional haematoxylin and eosin stained tumor tissue sections. The biomarker stratified stage II and III patients into sufficiently distinct prognostic groups that potentially could be used to guide treatment selection.

Cystic Fibrosis Patient Asks for Increased Efforts Around Antibiotic Resistance
Pew Trust, January 28, 2020

I am living with cystic fibrosis, and many of us with the condition rely on antibiotics every day. In the CF world, antibiotic resistance is commonplace. It is one of the leading complications that contribute to patient death.

Duchenne muscular dystrophy
H Fox et al, BMJ, January 2020

Consider Duchenne muscular dystrophy in boys with delayed motor milestones, positive Gowers’ sign, abnormal gait, muscle pains, calf hypertrophy, unexplained elevated liver enzymes, learning difficulties, behavioral problems, or speech and language delay. Early genetic diagnosis is important, as it can enable entry into appropriate clinical trials.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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