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Hot Topics of the Day|PHGKB
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01/09/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Polygenic Risk, Fitness, and Obesity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
VL Murthy et al, JAMA Cardiology, January 8, 2020

Comprehensive clinical risk profiles (incorporating BMI, its change over time, and behavioral factors), but not polygenic risk scores, offer substantial predictive ability for future BMI in the context of obesity prevention.

A brief history of human disease genetics
M Claussnitzer et al, Nature, January 8, 2020

Over the past 25 years, genetic discoveries have substantially improved our understanding of the mechanisms responsible for many rare and common diseases and driven development of novel preventative and therapeutic strategies. Medical innovation will increasingly focus on delivering care tailored to individual patterns of genetic predisposition.

The Gene Drive Dilemma: We Can Alter Entire Species, but Should We?
J Kahn, NY Times, January 8, 2020

A new genetic engineering technology could help eliminate malaria and stave off extinctions — if humanity decides to unleash it.

The Patient-Scientist's Mandate.
Vallabh Sonia M et al. The New England journal of medicine 2020 Jan (2) 107-109

8 years ago, at the age of 27, I learned that I had inherited a fatal genetic mutation in the prion protein gene). Pathogenic mutations in this gene cause prion disease, a rare adult-onset neurodegenerative disease that is rapidly fatal once it strikes. The mutation I carry makes me nearly certain to die of this disease if no preventive measure is developed.

Neurodevelopmental Abnormalities Associated With In Utero Zika Virus Infection in Infants and Children-The Unfolding Story.
Honein Margaret A et al. JAMA pediatrics 2020 Jan

It remains unknown whether the 90% to 95% of infants potentially congenitally exposed but without Zika virus–associated birth defects have a higher-than-baseline risk of neurodevelopmental abnormalities and, if so, how these disabilities may manifest over time.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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