Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

01/06/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

Gene Therapies Make It to Clinical Trials
L Marsa, Discover, December 2020

After years of ethical debates and breakthroughs in the lab, CRISPR has finally made its way to clinical trials. Researchers are now looking at whether the DNA-editing tool, as well as more conventional gene therapies, can effectively treat a wide array of heritable disorders and even cancers.

Genetic apps: raising more questions than they answer?
T Burki, January 1, 2020 Lancet Digital Health

Genetic factors, adherence to healthy lifestyle behavior, and risk of invasive breast cancer among women in the UK Biobank.
Arthur Rhonda S et al. Journal of the National Cancer Institute 2020 Jan

Using regression models, we examined the association of a modified healthy lifestyle index (HLI) with risk of invasive breast cancer by genetic risk group among 146,326 women from the UK Biobank. The study shows that an overall healthy lifestyle may attenuate the impact of genetic factors on invasive breast cancer risk among women of European ancestry.

Moving Molecular Profiling to Routine Clinical Practice: A Way Forward?
Freidlin Boris et al. Journal of the National Cancer Institute 2019 Dec

Molecular profiling of a patient’s tumor to guide targeted treatment selection offers the potential to advance patient care by improving outcomes and minimizing toxicity (by avoiding ineffective treatments). However, current development of molecular profile panels is often based on institution-specific or subjective algorithms to non-randomized patient cohorts

No multiplicative GXE interactions for breast cancer risk: Have we reached a verdict or is the jury still out?
Terry Mary Beth et al. International journal of epidemiology 2019 Dec

Thinking through ways to improve how we communicate the absence of multiplicative interactions while at the same time promoting a greater awareness of additive interactions, and absolute risk, remains a challenge.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP