Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
Sign up MyPHGKB to receive the daily hot topic email alert.Archived Hot Topics of the Day By Date
Cost-effectiveness and Return on Investment of a Nationwide Case-Finding Program for Familial Hypercholesterolemia in Children in the Netherlands.
Zanfina Ademi et al. JAMA Pediatr 2023 5 (Posted: May-02-2023 8AM)
Using deep learning-based natural language processing to identify reasons for statin nonuse in patients with atherosclerotic cardiovascular disease
A Sarraju et al, Comm Medicine, July 2022 (Posted: Jul-19-2022 8AM)
PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations.
Hao Qiukui et al. BMJ (Clinical research ed.) 2022 5 e069066 (Posted: May-11-2022 8AM)
When You Have Both: Managing FH and High Lp(a)
Family Heart Foundation, March 29, 2022 (Posted: Apr-01-2022 7AM)
A systematic review and meta-analysis of genotype-based and individualized data analysis of SLCO1B1 gene and statin-induced myopathy.
Turongkaravee Saowalak et al. The pharmacogenomics journal 2021 Feb (Posted: Feb-22-2021 7AM)
Effect of Pharmacogenetic Testing for Statin Myopathy Risk vs Usual Care on Blood Cholesterol
A Randomized Clinical Trial
JL Vassy et al, JAMA Network Open, December 2, 2020 (Posted: Dec-04-2020 11AM)
The Stroke Family
The FH Foundation, January 6, 2020 (Posted: Jan-07-2020 8AM)
Familial hypercholesterolemia and elevated lipoprotein(a): double heritable risk and new therapeutic opportunities.
Vuorio A et al. Journal of internal medicine 2020 Jan 287(1) 2-18 (Posted: Jan-02-2020 9AM)
Genetic contribution to lipid target achievement with statin therapy: a prospective study.
Ruiz-Iruela Cristina et al. The pharmacogenomics journal 2019 Dec (Posted: Dec-10-2019 8AM)
Many Adults with Familial Hypercholesterolemia Are Not Meeting Goal LDL-Cholesterol Level
RF Green et al, CDC Blog Post, November 15, 2019 (Posted: Nov-15-2019 0PM)
Making the Case for Early Statins in Familial Hypercholesterolemia
P Wendling, Medscape, October 16, 2019 (Posted: Oct-18-2019 8AM)
20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia
IK Luirink et al, NEJM, October 17, 2019 (Posted: Oct-17-2019 9AM)
The role of statins in the treatment of familial hypercholesterolemia
S Gilding, The FH Foundation, March 5, 2019 (Posted: Mar-06-2019 8AM)
Value of a Hypothetical Pharmacogenomic Test for the Diagnosis of Statin-Induced Myopathy in Patients at High Cardiovascular Risk.
Mitchell Dominic et al. Molecular diagnosis & therapy 2018 Sep (Posted: Sep-19-2018 9AM)
MicroRNAs and response to statins in patients with hypercholesterolemia: from basic research to precision medicine.
Zambrano Tomás et al. Pharmacogenomics 2018 May (Posted: May-23-2018 9AM)
Cardiovascular Genetic Risk Testing for Targeting Statin Therapy in the Primary Prevention of Atherosclerotic Cardiovascular Disease: A Cost-Effectiveness Analysis.
Jarmul Jamie et al. Circulation. Cardiovascular quality and outcomes 2018 Apr 11(4) e004171 (Posted: Apr-18-2018 10AM)
A Discrete Event Simulation Model to Assess the Economic Value of a Hypothetical Pharmacogenomics Test for Statin-Induced Myopathy in Patients Initiating a Statin in Secondary Cardiovascular Prevention.
Mitchell Dominic et al. Molecular diagnosis & therapy 2018 Apr (Posted: Apr-18-2018 10AM)
Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk
BA Ference, et al. JAMA, August 28, 2017 (Posted: Aug-28-2017 1PM)
PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity-Reply.
Koren Michael J et al. JAMA cardiology 2017 Aug (Posted: Aug-18-2017 8AM)
PCSK9 Inhibitors, Statins, Low-Density Lipoprotein Cholesterol, Mevalonate Pathway, and Toxicity.
Guijarro Carlos et al. JAMA cardiology 2017 Aug (Posted: Aug-18-2017 8AM)
How Studying Familial Hypercholesterolemia Resulted in the Discovery of Statins as an Effective Treatment for High Cholesterol
JAMA Podcast, July 25, 2017 (Posted: Jul-26-2017 8AM)
Statins for children with inherited high blood cholesterol
VA Kuoppola et al, Cochrane reviews, July 7, 2017 (Posted: Jul-07-2017 3PM)
The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-density Lipoprotein.
Kim Tae-Eun et al. Basic & clinical pharmacology & toxicology 2017 Jun (Posted: Jun-21-2017 8AM)
Younger Adults With Severe Dyslipidemia Less Likely to Be Prescribed Statins
TCTMD, January 5, 2017 (Posted: Jan-06-2017 7AM)
Statins for Prevention of Cardiovascular Disease in Adults
Evidence Report and Systematic Review for the US Preventive Services Task Force
R Chou et al, JAMA, November 15, 2016 (Posted: Nov-14-2016 6PM)
Cholesterol, Cardiovascular Risk, Statins, PCSK9 Inhibitors, and the Future of LDL-C Lowering
Fatima Rodriguez, et al, JAMA, November 15, 2016 (Posted: Nov-14-2016 6PM)
Statin Use for the Primary Prevention of Cardiovascular Disease in Adults
US Preventive Services Task Force Recommendation Statement
USPSTF, JAMA, November 15, 2016 (Posted: Nov-13-2016 2PM)
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.
Postmus Iris et al. Journal of medical genetics 2016 Sep (Posted: Sep-04-2016 9PM)
Statins in Heterozygous Familial Hypercholesterolemia
American College of Cardiology Foundation, July 11, 2016 (Posted: Jul-12-2016 7AM)
Prevalence of heterozygous familial hypercholesterolaemia and its impact on long-term prognosis in patients with very early ST-segment elevation myocardial infarction in the era of statins.
Rallidis Loukianos S et al. Atherosclerosis 2016 Mar 24917-21 (Posted: Apr-13-2016 11AM)
Seventeen years of statin pharmacogenetics: a systematic review.
Leusink Maarten et al. Pharmacogenomics 2016 Jan (2) 163-80 (Posted: Feb-22-2016 0PM)
Statin-Associated Autoimmune Myopathy
AL Mammen. NEJM, February 18, 2016 (Posted: Feb-22-2016 0PM)
Optimal Treatment using Statins from Childhood in Heterozygous Familial Hypercholesterolemia.
Nohara Atsushi et al. J. Atheroscler. Thromb. 2015 Sep 15. (Posted: Sep-16-2015 3PM)
Prevention of hepatocellular carcinoma by correction of metabolic abnormalities: Role of statins and metformin.
Ampuero Javier et al. World J Hepatol 2015 May 18. (8) 1105-11 (Posted: Jun-10-2015 11AM)
NIH Research Matters: Genetics Help Predict Heart Disease Risk, Statin Benefits
(Posted: Mar-23-2015 2PM)
Statins work for those at highest risk of heart attack - study,
the Guardian, March 3, 2015 (Posted: Mar-04-2015 9AM)
High Blood Cholesterol
From NHLBI health topic site (Posted: Jan-01-2014 0AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2023
- Page last updated:Jun 07, 2023
- Content source: