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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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81 hot topic(s) found with the query "Proteomics"

Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma
L Jiang et al, Nature Medicine, January 29, 2024 (Posted: Jan 29, 2024 8AM)

From the abstract: "Adjuvant chemotherapy benefits patients with resected pancreatic ductal adenocarcinoma (PDAC), but the compromised physical state of post-operative patients can hinder compliance. Biomarkers that identify candidates for prompt adjuvant therapy are needed. In this prospective observational study, 1,171 patients with PDAC who underwent pancreatectomy were enrolled and extensively followed-up. Proteomic profiling of 191 patient samples unveiled clinically relevant functional protein modules. A proteomics-level prognostic risk model was established for PDAC, with its utility further validated using a publicly available external cohort. "

Challenges and best practices in omics benchmarking.
Thomas G Brooks et al. Nat Rev Genet 2024 1 (Posted: Jan 15, 2024 10AM)

From the abstract: "Benchmarking refers to the process of objectively comparing and evaluating the performance of different computational or analytical techniques when processing and analysing large-scale biological data sets, such as transcriptomics, proteomics and metabolomics. With thousands of omics benchmarking studies published over the past 25 years, the field has matured to the point where the foundations of benchmarking have been established and well described. "

We need a genomics-savvy healthcare workforce
Nature Medicine, August 16, 2023 (Posted: Aug 17, 2023 11AM)

The increasingly central role of genomics in healthcare means that not only are more genetic counselors needed, but also multidisciplinary teams are essential for utilizing genomic technologies in the clinical setting. Genomic tests (such as those based on whole-exome or whole-genome sequencing) generate an enormous amount of highly complex data, which requires professionals with specialized bioinformatic skills and the know-how to operate within clinically accredited frameworks. In addition, although genomics is currently the most common ‘-omic’ used in the clinic, transcriptomics and proteomics are also being incorporated into algorithms to inform clinical practice.

Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis
S Zhou et al, Nature Genetics, August 9, 2023 (Posted: Aug 09, 2023 4PM)

We undertook a large-scale multiancestry exome-wide association study for estimated bone mineral density, which showed that the burden of rare coding alleles in 19 genes was associated with estimated bone mineral density (P<3.6×10–7). These genes were highly enriched for a set of known causal genes for osteoporosis (65-fold; P=2.5×10–5). Exome-wide significant genes had 96-fold increased odds of being the top ranked effector gene at a given GWAS locus (P=1.8×10–10). By integrating proteomics Mendelian randomization evidence, we prioritized CD109 (cluster of differentiation 109) as a gene for which heterozygous loss of function is associated with higher bone density.

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
Erik C B Johnson et al. Nat Med 2023 8 (Posted: Aug 08, 2023 8PM)

Here we show that proteomic measurements in autosomal dominant AD cerebrospinal fluid (CSF) linked to brain protein coexpression can be used to characterize the evolution of AD pathology over a timescale spanning six decades. SMOC1 and SPON1 proteins associated with Aß plaques were elevated in AD CSF nearly 30 years before the onset of symptoms, followed by changes in synaptic proteins, metabolic proteins, axonal proteins, inflammatory proteins and finally decreases in neurosecretory proteins. The proteome discriminated mutation carriers from noncarriers before symptom onset as well or better than Aß and tau measures.

Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.
Keenan A Walker et al. Sci Transl Med 2023 7 (705) eadf5681 (Posted: Jul 24, 2023 1PM)

Here, we used a large-scale proteomics platform to examine the association of 4877 plasma proteins with 25-year dementia risk in 10,981 middle-aged adults. We found 32 dementia-associated plasma proteins that were involved in proteostasis, immunity, synaptic function, and extracellular matrix organization. We then replicated the association between 15 of these proteins and clinically relevant neurocognitive outcomes in two independent cohorts. We demonstrated that 12 of these 32 dementia-associated proteins were associated with cerebrospinal fluid (CSF) biomarkers of AD, neurodegeneration, or neuroinflammation.

From Mendel to multi-omics: shifting paradigms
TB Mersha, EJHG, July 20, 2023 (Posted: Jul 20, 2023 7AM)

Multi-omics analysis is an emerging approach that aims to better understand health and disease through the convergence of different omics studies (genomics, transcriptomics, proteomics, metabolomics, metagenomics, phenomics, exposomics). Although technical limitations related to the analysis of high-dimensional multi-omics datasets and use of fairly small samples have hindered our ability to conduct multi-omic research, emerging technology and computational tools have facilitated impactful multi-omic research.

Proteomic characterization of acute kidney injury in patients hospitalized with SARS-CoV2 infection
I Paranjpe et al, Comm Med, June 12, 2023 (Posted: Jun 12, 2023 9AM)

Acute kidney injury (AKI) is a known complication of COVID-19 and is associated with an increased risk of in-hospital mortality. Unbiased proteomics using biological specimens can lead to improved risk stratification and discover pathophysiological mechanisms. Using clinical and proteomic data, our results suggest that while both acute and long-term COVID-associated kidney dysfunction are associated with markers of tubular dysfunction, AKI is driven by a largely multifactorial process involving hemodynamic instability and myocardial damage.

Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma.
Nardhy Gomez-Lopez et al. Communications medicine 2023 4 (1) 48 (Posted: Apr 07, 2023 8AM)

Herein, we profile the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls and show alterations that display a dose-response relationship with disease severity; yet, such proteomic perturbations are dampened during pregnancy. In both pregnant and non-pregnant state, the proteome response induced by COVID-19 shows enrichment of mediators implicated in cytokine storm, endothelial dysfunction, and angiogenesis.

Sepsis as a Challenge for Personalized Medicine
R Zahorek et al, J Per Med, December 1, 2022 (Posted: Dec 01, 2022 3PM)

The remarkable progress in clinical medicine in the field of Sepsis can be attributed to basic research, genomics and proteomics, together with a better understanding of the immunopathology, biology and epidemiology of sepsis syndrome. The aim of this Special Issue is to provide research evidence and potential uses for personalized medicine in Sepsis, highlighting eight papers focused on research achievements in animal and human studies.

Broad-capture proteomics and machine learning for early detection of type 2 diabetes risk
Nature Medicine, November 10, 2022 (Posted: Nov 11, 2022 7AM)

Impaired glucose tolerance (IGT) is a common condition that affects glucose control after sugar consumption. Isolated IGT is undetected by screening and diagnostic strategies, leaving affected individuals at high risk of developing diabetes. Here, a machine-learning framework identifies a three-protein signature for detecting isolated IGT from a single blood sample.

From Genomics to Proteomics— What’s the Impact on Population Health?
D Rasooly et al, CDC Blog Post, September 30, 2022 Brand (Posted: Sep 30, 2022 0PM)

New insights into the genome have led to the emergence of proteomics, the study of the structure and function of an individual’s entire set of expressed proteins. Proteomics is highly linked to genomics, since the blueprint for each protein is inscribed on an organism’s genes. This field of study has great potential for advancing health and medicine.

After the Genome—A Brief History of Proteomics
M Suran, JAMA, August 31, 2022 (Posted: Aug 31, 2022 0PM)

With researchers touting recent success in sequencing the human genome’s remaining gaps, an emerging frontier is proteomics: identifying and studying an entire set of expressed proteins in the human body and other organisms. Collectively, these sets are called proteomes, and unlike genomes, proteomes alter over time and depict current health conditions—not conditions at risk of occurring.

Neutrophil proteomics identifies temporal changes and hallmarks of delayed recovery in COVID19
MB Long et al, MEDRXIV, August 22, 2022 (Posted: Aug 23, 2022 8AM)

Neutrophil changes associated with COVID19 disease severity and prolonged illness were characterized and candidate targets for modulation of neutrophil function were identified. Delayed recovery from COVID19 was associated with changes in metabolic and signalling proteins, complement, chemokine and leukotriene receptors, integrins and inhibitory receptors.

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19
M Pietzner et al, Nat Comms, August 15, 2022 (Posted: Aug 15, 2022 7PM)

Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but unreported (e.g., RAB2A) candidate protein mediators of COVID-19 outcomes by integrating results from the COVID-19 Host Genetics Initiative with population-based plasma proteomics using statistical colocalisation.

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
K Sacco et al, Nature Medicine, February 17, 2022 (Posted: Feb 17, 2022 8AM)

In this longitudinal multi-institutional study, we applied multi-omics (analysis of soluble biomarkers, proteomics, single-cell gene expression and immune repertoire analysis) to profile children with COVID-19 (n?=?110) and MIS-C (n?=?76), along with pediatric healthy controls (pHCs; n?=?76). pCOVID-19 was characterized by robust type I interferon (IFN) responses, whereas prominent type II IFN-dependent and NF-?B-dependent signatures, matrisome activation and increased levels of circulating spike protein were detected in MIS-C, with no correlation with SARS-CoV-2 PCR status around the time of admission.

Large-scale integration of the plasma proteome with genetics and disease
E Ferkingstad et al, Nature Genetics, December 2, 2021 (Posted: Dec 03, 2021 11AM)

The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and levels of proteins in plasma. We identified 938 genes encoding potential drug targets with variants that influence levels of possible biomarkers. Combining proteomics, genomics and transcriptomics, we provide a valuable resource that can be used to improve understanding of disease pathogenesis and to assist with drug discovery and development.

Immunoprecipitation-targeted proteomics assays facilitate rational development of SARS-CoV-2 serological diagnostics
Z Fu et al, MEDRXIV, October 26, 2021 (Posted: Oct 27, 2021 10AM)

The growing need for controlled data access models in clinical proteomics and metabolomics
TM Keane et al, Nature Communications, October 2021 (Posted: Oct 04, 2021 9AM)

More and more clinical studies include potentially sensitive human proteomics or metabolomics datasets, but bioinformatics resources for managing the access to these data are not yet available. This commentary discusses current best practices and future perspectives for the responsible handling of clinical proteomics and metabolomics data.

20 years of precision medicine in oncology
The Lancet editorial, May 15, 2021 (Posted: May 19, 2021 8AM)

In the 20 years since the publication of the first draft of the human genome project, the use of genotyping and genomics have become part of standard treatment for some cancers. The desire to go beyond blanket, and often difficult, treatments for patients to a more refined, efficient, and patient-centered approach is an ideal that is hard to oppose. But as precision medicine in oncology expands to include big data, proteomics, transcriptomics, molecular imaging, and more, there are serious challenges ahead to translate that ideal into meaningful and equitable health care for patients.

Next generation plasma proteome profiling to monitor health and disease
W Zhong et al, Nature Comms, May 3, 2021 (Posted: May 05, 2021 7AM)

The need for precision medicine approaches to monitor health and disease makes it important to develop sensitive and accurate assays for proteome profiles in blood. Here, we describe an approach for plasma profiling based on proximity extension assay combined with next generation sequencing.

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
A Stukalov et al, Nature Medicine, April 12, 2021 (Posted: Apr 13, 2021 6AM)

Revealing the role of the human blood plasma proteome in obesity using genetic drivers.
Zaghlool Shaza B et al. Nature communications 2021 2 (1) 1279 (Posted: Feb 26, 2021 8AM)

Many proteins have been linked to complex disorders and are also under substantial genetic control. Here, we investigate the associations between over 1000 blood circulating proteins and body mass index (BMI) in three studies including over 4600 participants. We show that BMI is associated with widespread changes in the plasma proteome. We observe 152 replicated protein associations with BMI.

Quantitative plasma proteomics of survivor and non-survivor COVID-19 patients admitted to hospital unravels potential prognostic biomarkers and therapeutic targets
DC Di Flora et al, MEDRXIV, January 2, 2021 (Posted: Jan 04, 2021 7AM)

Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens.
K Bezstarosti et al, BIORXIV, December 18, 2020 (Posted: Dec 19, 2020 7AM)

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Zheng Jie et al. Nature genetics 2020 Sep (Posted: Sep 09, 2020 9AM)

The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here we estimated the effects of 1,002 proteins on 225 phenotypes using two-sample Mendelian randomization (MR) and colocalization.

Genetics meets proteomics: perspectives for large population-based studies
K Suhre et al, Nature Rev Genetics, August 28, 2020 (Posted: Aug 29, 2020 0PM)

We review current findings from studies of the plasma proteome and discuss their potential for advancing biomedical translation through the interpretation of genome-wide association analyses. We highlight the challenges faced by currently available technologies and provide perspectives relevant to their future application in large-scale biobank studies.

Strategies to enable large-scale proteomics for reproducible research
RC Poulos et al, Nature Comms, July 30, 2020 (Posted: Jul 31, 2020 8AM)

Reproducible research is the bedrock of experimental science. To enable the deployment of large-scale proteomics, we assess the reproducibility of mass spectrometry (MS) over time and across instruments and develop computational methods for improving quantitative accuracy.

Lung Adenocarcinoma (LUAD) Discoveries from two NCI Proteomics Consortia
NCI, July 9, 2020 Brand (Posted: Jul 10, 2020 6AM)

Advances in genomics have revealed new insights in the biology of LUAD, but comprehensive information about how various gene mutations lead to this disease is still lacking. Investigators addressed this challenge by adding comprehensive proteomics to genomics, or proteogenomics, to reveal an additional dimension of lung cancer biology.

Proteomics Uncovers Immunosuppression in COVID-19 Patients with Long Disease Course
S Tang et al, MEDRXIV, June 17, 2020 (Posted: Jun 18, 2020 8AM)

Serum proteomics in COVID-19 patients: Altered coagulation and complement status as a function of IL-6 level
A D'Alessandro et al, MEDRXIV, May 29, 2020 (Posted: May 31, 2020 7AM)

Proteomics of SARS-CoV-2-infected host cells reveals therapy targets
D Bojkova et al, Nature, May 14, 2020 (Posted: May 16, 2020 7AM)

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics
CB Messner et al, MEDRXIV, May 3, 2020 (Posted: May 03, 2020 7AM)

TARGETED PROTEOMICS FOR THE DETECTION OF SARS-COV-2 PROTEINS.
BIORXIV, April 23, 2020 (Posted: Apr 25, 2020 7AM)

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
J Zheng et al, BIORXIV, December 2019 (Posted: Dec 10, 2019 8AM)

The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here, we estimated the effects of 1002 proteins on 225 phenotypes using two-sample Mendelian randomization.

Leveraging -omics for asthma endotyping
SR Tyler et al, JACI, July 2019 (Posted: Jul 02, 2019 0PM)

Asthma is a highly heterogeneous disease, The eliciting factors, natural history, underlying molecular biology, and clinical management of asthma vary highly among affected subjects. Because of this variation, many efforts have gone into subtyping asthma. Endotypes are subtypes of disease based on distinct pathophysiologic mechanisms. We discuss the application of -omics approaches, including transcriptomics, epigenomics, microbiomics, metabolomics, and proteomics, to asthma endotyping. -Omics approaches have provided supporting evidence for many existing endotyping paradigms and also suggested novel ways to conceptualize asthma endotypes.

Genomics, microbiomics, proteomics, and metabolomics in bronchopulmonary dysplasia.
Lal Charitharth Vivek et al. Seminars in perinatology 2018 Nov (7) 425-431 (Posted: Jan 23, 2019 10AM)

Exposure to tobacco smoke and low birth weight: from epidemiology to metabolomics.
Dessì Angelica et al. Expert review of proteomics 2018 Jul (Posted: Jul 30, 2018 8AM)

Genomic atlas of the human plasma proteome
BB Sun et al, Nature, June 6, 2018 (Posted: Jun 07, 2018 9AM)

The use of omics profiling to improve outcomes of bone regeneration and osseointegration. How far are we from personalized medicine in dentistry?
Calciolari E et al. Journal of proteomics 2018 Feb (Posted: Feb 27, 2018 9AM)

Circulating Tumor DNA as Biomarkers for Cancer Detection
X Han et al, Genomics, Proteomics and Bioinformatics, April 2017 (Posted: May 13, 2017 6AM)

Proteomics of Atrial Fibrillation- Evolving From a Coarse Understanding to a Fine Phenotype
C Hyman, JAMA Cardiology, March 29, 2017 (Posted: Apr 03, 2017 2PM)

Beyond genomics: Using proteomics to target tumors
Fred Hutchinson Cancer Center, March 2017 (Posted: Apr 03, 2017 2PM)

Personalized Medicine in Respiratory Disease: Role of Proteomics.
Priyadharshini V S et al. Advances in protein chemistry and structural biology 2016 115-46 (Posted: Feb 06, 2017 1PM)

ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.
Gupta Amit Kumar et al. Scientific reports 2016 Sep 32713 (Posted: Nov 01, 2016 9AM)

Immunomic approaches for antigen discovery of human parasites.
Kassegne Kokouvi et al. Expert review of proteomics 2016 Oct (Posted: Oct 26, 2016 7PM)

Postgenomics biomarkers for rabies—the next decade of proteomics.
Mehta Shraddha M et al. Omics : a journal of integrative biology 2015 Feb (2) 67-79 (Posted: Sep 28, 2016 4PM)

The Present and Future of Biomarkers in Prostate Cancer: Proteomics, Genomics, and Immunology Advancements.
Gaudreau Pierre-Olivier et al. Biomarkers in cancer 2016 (Suppl 2) 15-33 (Posted: Sep 19, 2016 9AM)

The Significance of Proteomic Biomarkers in Male Breast Cancer.
Zografos Eleni et al. Cancer genomics & proteomics (3) 183-190 (Posted: Jul 25, 2016 8PM)

Towards Better Precision Medicine: PacBio Single-Molecule Long Reads Resolve the Interpretation of HIV Drug Resistant Mutation Profiles at Explicit Quasispecies (Haplotype) Level.
Huang Da Wei et al. Journal of data mining in genomics & proteomics 2016 Jan (1) (Posted: Jun 27, 2016 10AM)

Clinical utility of serum biomarkers in Duchenne muscular dystrophy.
Hathout Yetrib et al. Clinical proteomics 2016 9 (Posted: Apr 16, 2016 6PM)

Proteomic contributions to our understanding of vaccine and immune responses.
Galassie Allison C et al. Proteomics. Clinical applications 2015 Dec (11-12) 972-89 (Posted: Feb 23, 2016 6AM)

Single-cell Transcriptome Study as Big Data.
Yu Pingjian et al. Genomics, proteomics & bioinformatics 2016 Feb (Posted: Feb 22, 2016 4PM)

Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers
Maria M. Esterhuysea, et al. Mbio, November 2015 (Posted: Nov 07, 2015 0PM)

Genomic, Proteomic, and Metabolomic Data Integration Strategies.
Wanichthanarak Kwanjeera et al. Biomarker insights 2015 (Suppl 4) 1-6 (Posted: Nov 05, 2015 0PM)

Exploring the potential of public proteomics data.
Vaudel Marc et al. Proteomics 2015 Oct (Posted: Nov 05, 2015 11AM)

Progress in proteomics for clinical microbiology: MALDI-TOF MS for microbial species identification and more.
van Belkum Alex et al. Expert review of proteomics 2015 Oct 1-11 (Posted: Nov 05, 2015 11AM)

Translational Research and Plasma Proteomic in Cancer.
Santini Annamaria Chiara et al. Journal of cellular biochemistry 2015 Oct (Posted: Nov 05, 2015 11AM)

Proteomics and drug discovery in cancer.
Dias Matheus H et al. Drug discovery today 2015 Oct (Posted: Nov 05, 2015 11AM)

Proteomics in the genome engineering era.
Vandemoortele Giel et al. Proteomics 2015 Oct (Posted: Nov 05, 2015 11AM)

The expanding landscape of the thiol redox proteome.
Yang Jing et al. Molecular & cellular proteomics : MCP 2015 Oct (Posted: Nov 05, 2015 11AM)

Next generation sequencing technologies in cancer diagnostics and therapeutics: A mini review.
Li W et al. Cellular and molecular biology (Noisy-le-Grand, France) 2015 (5) 91-102 (Posted: Nov 05, 2015 11AM)

Streptococcus pneumoniae proteomics: determinants of pathogenesis and vaccine development.
Bittaye Mustapha et al. Expert review of proteomics 2015 Nov 1-15 (Posted: Nov 05, 2015 11AM)

Proteomics: High-protein research
N Savage, Nature Outlook, November 4, 2015 (Posted: Nov 05, 2015 11AM)

Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt-Jakob disease.
Kipkorir Terry et al. Proteomics 2015 May 1. (Posted: Jun 11, 2015 4AM)

High throughput proteomic analysis and a comparative review identify the nuclear chaperone, Nucleophosmin among the common set of proteins modulated in Chikungunya virus infection.
Abraham Rachy et al. J Proteomics 2015 Apr 29. 126-41 (Posted: May 15, 2015 11AM)

Assessment of the association between micronuclei and the degree of uterine lesions and viral load in women with human papillomavirus.
Adam Mônica Lúcia et al. Cancer Genomics Proteomics 2015 Mar-Apr (2) 67-71 (Posted: May 06, 2015 9AM)

ERAP1 polymorphism relevant to inflammatory disease shapes the peptidome of the birdshot chorioretinopathy-associated HLA-A*29:02 antigen.
Alvarez-Navarro Carlos et al. Mol. Cell Proteomics 2015 Apr 19. (Posted: May 05, 2015 10AM)

Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.
Lance Eboni I et al. Proteomics Clin Appl 2014 Dec (11-12) 813-27 (Posted: May 01, 2015 11AM)

Biological Databases for Human Research.
Zou Dong et al. Genomics Proteomics Bioinformatics 2015 Feb (1) 55-63 (Posted: Apr 14, 2015 0PM)

Development of data representation standards by the human proteome organization proteomics standards initiative.
Deutsch Eric W et al. J Am Med Inform Assoc 2015 Feb 28. (Posted: Apr 11, 2015 8AM)

Proteomics of Colorectal Cancer in a Genomic Context: First Large-Scale Mass Spectrometry-Based Analysis from the Cancer Genome Atlas.
Jimenez Connie R et al. Clin. Chem. 2015 Feb 26. (Posted: Apr 02, 2015 8PM)

Proteomics as the final step in the functional metagenomics study of antimicrobial resistance.
Fouhy Fiona et al. Front Microbiol 2015 172 (Posted: Mar 30, 2015 5PM)

Possible Biomarkers for the Early Detection of HIV-associated Heart Diseases: A Proteomics and Bioinformatics Prediction.
Rasheed Suraiya et al. Comput Struct Biotechnol J 2015 145-52 (Posted: Mar 30, 2015 6AM)

Web Resources for Pharmacogenomics.
Zhang Guoqing et al. Genomics Proteomics Bioinformatics 2015 Feb 19. (Posted: Mar 11, 2015 10AM)

Implications of functional proteomics in breast cancer.
Chae Young Kwang et al. Oncologist 2014 Apr (4) 328-35 (Posted: Mar 04, 2015 9PM)

Research progress in applying proteomics technology to explore early diagnosis biomarkers of breast cancer, lung cancer and ovarian cancer.
Luo Lu et al. Asian Pac. J. Cancer Prev. 2014 (20) 8529-38 (Posted: Mar 04, 2015 8PM)

Biomarkers for pancreatic cancer: recent achievements in proteomics and genomics through classical and multivariate statistical methods.
Marengo Emilio et al. World J. Gastroenterol. 2014 Oct 7. (37) 13325-42 (Posted: Feb 28, 2015 11AM)

Phenome-genome association studies of pancreatic cancer: new targets for therapy and diagnosis.
Narayanan Ramaswamy et al. Cancer Genomics Proteomics 0 (1) 9-19 (Posted: Feb 28, 2015 11AM)

Epigenetic Silencing of GNMT Gene in Pancreatic Adenocarcinoma.
Botezatu Anca et al. Cancer Genomics Proteomics 0 (1) 21-30 (Posted: Feb 28, 2015 11AM)

Metabolomics in Population-Based Research
Brand (Posted: Jan 11, 2014 11AM)

Metabolomics is the study of small molecules of both endogenous and exogenous origin, such as metabolic substrates and their products, lipids, small peptides, vitamins and other protein cofactors generated by metabolism, which are downstream from genes. This approach has received more attention in recent years as an ideal methodology to unravel signals closer to the culmination of the disease process. The compounds identified through metabolomic profiling represent a range of intermediate metabolic pathways that may serve as biomarkers of exposure, susceptibility, or disease. In short, it is a valuable approach for deciphering metabolic outcomes with a phenotypic change. Until recently, metabolomics and other post-genomic platforms, such as proteomics and transcriptomics, have not been suitable for large-scale, high-throughput epidemiologic applications. Studies that employed metabolomics technologies have focused on toxicological, physiological, and disease responses in animal models and small-scale human studies. This has been due mainly to the limited capacity of the analytical platforms for sample throughput and the processing requirements for the enormous amounts of data created. Improved sample preparation, robotic sample-delivery systems, automated data processing, and use of multivariate statistical and chemometric methods, with associated reductions in cost, are now allowing researchers to realize the potential for metabolic phenotyping in epidemiology. Investigators have begun to extend these studies to larger-scale population studies for biomarker discovery. With these studies comes the challenge of applying metabolomics technologies in a manner that generates meaningful results. Epidemiologists must strive to comprehensively understand the principles of metabolomics to determine when it is appropriate to use biomarkers identified using this technology, which includes the ability to determine when biomarkers have been validated sufficiently. Cancer


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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