169 hot topic(s) found with the query "Pregnancy"
Pregnancy advances your 'biological' age - but giving birth turns it back.
Saima Sidik et al. Nature 2024 3
(Posted: Mar 25, 2024 9AM)
From the article: " DNA-methylation patterns can be used to estimate a person’s ‘biological age’, which reflects the physiological stresses that a person’s body has accrued over time. Some research has found that biological age is a better predictor of health problems such as cardiovascular disease3 and dementia4 than a person’s chronological age. Pregnancy may lead to changes in the distribution of certain chemical markers on a pregnant person’s DNA — changes similar to those that are a hallmark of getting older. But new research shows that, several months after a person gives birth, the chemical patterns revert to an earlier state. The results strengthen previous preliminary results in humans. "
Researchers one step closer to preventing preeclampsia
Medical XPress, APA, March 14, 2024
(Posted: Mar 18, 2024 3PM)
From the website: "Researchers have identified several differences in DNA methylation in people who experienced preeclampsia during pregnancy, according to a new study from Oregon Health & Science University. The study also revealed these differences appear to occur in connection to genes relevant to the disease. "
Prenatal Genetic Testing Is Rapidly Evolving. Here’s Why That Matters.
M Holmes, Huffington Post, January 12, 2024
(Posted: Jan 14, 2024 10AM)
From the article: " In the context of pregnancy, the role of DNA testing is to uncover genetic disease in a fetus. (An additional bonus for parents is learning the baby’s sex, which many are eager to know.) Unfortunately, genetic testing in pregnancy often isn’t as conclusive or uncomplicated as the DNA testing police use to determine whether someone was at the scene of a crime."
Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes: A Mendelian Randomization Study.
Tormod Rogne et al. JAMA Netw Open 2024 1 (1) e2351166
(Posted: Jan 12, 2024 6AM)
From the abstract: " Which pathways mediate the inequity in pregnancy health associated with low educational attainment? In this cohort study of more than 3 million individuals, an association between genetically estimated lower educational attainment and increased risk of ectopic pregnancy, hyperemesis gravidarum, gestational diabetes, preeclampsia, preterm birth, and offspring low birth weight was observed. A sizeable portion of these associations were explained by targetable risk factors. These findings suggest that the association of socioeconomic inequalities with adverse pregnancy outcomes may be reduced by intervening for type 2 diabetes, body mass index, smoking, high-density lipoprotein cholesterol level, and systolic blood pressure."
Pregnancy After Breast Cancer in Young BRCA Carriers An International Hospital-Based Cohort Study
M Lambertini et al, JAMA Network Open, December 7, 2023
(Posted: Dec 08, 2023 2PM)
From the abstract: "Among women carrying germline BRCA pathogenic variants, is pregnancy after breast cancer associated with adverse maternal or fetal outcomes? This international, hospital-based, retrospective cohort study including 4732 BRCA carriers showed that 1 in 5 patients conceived within 10 years after breast cancer diagnosis. Pregnancy following breast cancer in BRCA carriers was not associated with adverse maternal prognosis or fetal outcomes.
The cumulative incidence of pregnancy after breast cancer and disease-free survival in this large international cohort of young BRCA carriers may inform care for affected patients. "
What Is Prediabetes?
J Jin, JAMA Patient Corner, December 1, 2023
(Posted: Dec 02, 2023 9AM)
From the article: " Prediabetes affects approximately 1 in 3 US adults and about 720 million individuals worldwide. People with prediabetes often have no symptoms, so most people with prediabetes do not know they have it. Risk Factors for Prediabetes include: Being older than 45 years; Being overweight or obese; Being physically active less than 3 times a week; Eating an unhealthy diet; Having a parent or sibling with type 2 diabetes; Having a history of diabetes during pregnancy (gestational diabetes) or giving birth to an infant weighing more than 9 pounds; Having polycystic ovary syndrome."
Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss.
Rick Essers et al. Nat Med 2023 11
(Posted: Nov 27, 2023 10AM)
From the abstract: "Pregnancy loss is often caused by chromosomal abnormalities of the conceptus. The prevalence of these abnormalities and the allocation of (ab)normal cells in embryonic and placental lineages during intrauterine development remain elusive. In this study, we analyzed 1,745 spontaneous pregnancy losses and found that roughly half (50.4%) of the products of conception (POCs) were karyotypically abnormal, with maternal and paternal age independently contributing to the increased genomic aberration rate. "
mRNA SARS-CoV-2 Vaccination Before vs During Pregnancy and Omicron Infection Among Infants.
Orlanda Goh et al. JAMA Netw Open 2023 11 (11) e2342475
(Posted: Nov 11, 2023 4PM)
From the abstract: "s maternal vaccination associated with a lower risk of infection with Omicron SARS-CoV-2 variants, including XBB, among infants up to 6 months of age? In this national population-based cohort study of 7292 infants aged 6 months or younger in Singapore, the estimated vaccine effectiveness in infants against Omicron SARS-CoV-2 variants, including XBB, from maternal messenger RNA (mRNA) SARS-COV-2 vaccination was 42%. A lower risk of infection was only found in infants when the vaccine was administered during pregnancy. "
Prevalence and course of pregnancy symptoms using self-reported pregnancy app symptom tracker data
M Nissen et al, NPJ Digital Medicine, October 11, 2023
(Posted: Oct 11, 2023 4PM)
From the abstract: "We report real-world evidence from patient-reported outcomes that exceeds previous works: 1,549,186 tracked symptoms from 183,732 users of a smartphone pregnancy app symptom tracker are analyzed. The majority of users track symptoms on a single day. These data are generalizable to those users who use the tracker for at least 5 months. Week-by-week symptom report data are presented for each symptom. "
Deep representation learning identifies associations between physical activity and sleep patterns during pregnancy and prematurity.
Neal G Ravindra et al. NPJ Digit Med 2023 9 (1) 171
(Posted: Sep 29, 2023 7AM)
From the abstract: "In this study, we use physical activity data collected using a wearable device comprising over 181,944?h of data across N?=?1083 patients. Using a new state-of-the art deep learning time-series classification architecture, we develop a ‘clock’ of healthy dynamics during pregnancy by using gestational age (GA) as a surrogate for progression of pregnancy. We also develop novel interpretability algorithms that integrate unsupervised clustering, model error analysis, feature attribution, and automated actigraphy analysis, allowing for model interpretation with respect to sleep, activity, and clinical variables. "
Using the methylome to predict pre-eclampsia
Tu’uhevaha J. Kaitu’u-Lino et al, Nature Medicine, August 28, 2023
(Posted: Aug 28, 2023 1PM)
From the abstract: "A blood test done in early pregnancy that measures cell-free DNA methylation could represent a novel way to predict the risk of preterm pre-eclampsia. Pre-eclampsia is a serious complication that imperils the lives of women and their unborn babies. Arising in 3–5% of pregnancies, it claims the lives of 60,000 pregnant women every year around the world. For every death, it is estimated that 50–100 women encounter permanent health ailments because of a pre-eclamptic pregnancy; pre-eclampsia is also associated with adverse fetal mortality and morbidity."
Transforming preeclampsia diagnosis: The promising role of cfRNA
News Medical, August 15, 2023
(Posted: Aug 18, 2023 8AM)
Preeclampsia is a serious pregnancy disorder marked by elevated blood pressure and the presence of proteins in urine. It impacts approximately 2% to 4% of expectant mothers worldwide, resulting in approximately 46,000 maternal fatalities and roughly 500,000 deaths of both fetuses and newborns annually.
A recent study illuminates a potential diagnostic avenue for this condition utilizing plasma cell-free RNA (cfRNA).
Genomic testing for rare disease diagnosis—where are we now, and where should we be heading? The reflections of a behavioural scientist
C Lewis, EJHG, August 1, 2023
(Posted: Aug 01, 2023 9AM)
Much work has been done by behavioral scientists over recent years to understand patients’ and parents’ motivations for undergoing genomic testing. Findings highlight patients’ and parents’ desire: for a diagnosis to access treatments, for access to clinical trials and/or disease-specific screening; to receive a clear prognosis and information about recurrence risk; to understand the etiology of the condition and receive a reason “why” it occurred; to gain relief from guilt, for example, that it was not caused by something the mother did during her pregnancy (a concern I frequently come across); to gain legitimacy for the patient’s behavior and/or appearance; and to enable them the opportunity to connect with others through support groups and social media.
Multilevel barriers and facilitators to widespread use of preconception carrier screening in the United States
LE Hull et al, Genetics in Medicine, July 30, 2023
(Posted: Jul 31, 2023 11AM)
Although preconception reproductive genetic carrier screening (RGCS) is preferred to screening during pregnancy, population-wide preconception screening is not routinely performed in the U.S. We explored the multilevel barriers to the widespread adoption of preconception RGCS in the U.S. via key informant interviews. Barriers to preconception RGCS were identified at the levels of test characteristics, patients and couples, clinicians and care teams, and the external healthcare and policy environments.
Study provides a more complete picture of sickle cell disease mortality burden
L Ramsey, News Medical, June 2023
(Posted: Jun 16, 2023 8AM)
A new study suggests the number of deaths due to sickle cell disease is 11 times higher than what is indicated from mortality data sources alone. Sickle cell disease is not just underdiagnosed, but it also increases risk of infection and of death from conditions like stroke, heart problems, kidney problems, and pregnancy complications.
Early Pregnancy Loss
K Walter, JAMA, April 2023
(Posted: Apr 16, 2023 6AM)
Early pregnancy loss is caused most commonly by fetal chromosomal abnormalities, which account for more than two-thirds of all early pregnancy loss between 6 and 10 weeks of gestation. Risk factors for early pregnancy loss include older age at onset of pregnancy, prior pregnancy loss, some medical conditions (such as diabetes, hyperthyroidism, and lupus), and exposures during pregnancy that may harm a developing fetus (such as alcohol; some viral or bacterial infections; environmental exposure to lead, mercury, or radiation; and certain medications).
Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma.
Nardhy Gomez-Lopez et al. Communications medicine 2023 4 (1) 48
(Posted: Apr 07, 2023 8AM)
Herein, we profile the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls and show alterations that display a dose-response relationship with disease severity; yet, such proteomic perturbations are dampened during pregnancy. In both pregnant and non-pregnant state, the proteome response induced by COVID-19 shows enrichment of mediators implicated in cytokine storm, endothelial dysfunction, and angiogenesis.
A Parent’s Guide to Genetics and Hearing Loss
CDC, 2023
(Posted: Mar 31, 2023 7AM)
About 1 in 500 infants are born with or develop hearing loss during early childhood. Screening for hearing loss is considered standard care in the United States and in 2019 over 98% of children were screened, usually before leaving the hospital. Hearing loss has many causes, including genetic causes (that is, caused by the instructions in the baby’s cells) and non-genetic causes (such as certain infections the mother has during pregnancy or infections affecting the newborn baby).
Maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization
M Lipshhuetz et al, Nature Medicine, March 23, 2023
(Posted: Mar 24, 2023 6AM)
Compared to the second dose, the third dose was associated with reduced infant hospitalization with estimated effectiveness of 53% (95% CI: 36–65%). Greater protection was associated with a shorter interval between vaccination and delivery. A third maternal dose during pregnancy reduced the risk of infant hospitalization for COVID-19 during the first 4?months of life, supporting clinical and public health guidance for maternal booster vaccination to prevent infant COVID-19 hospitalization.
Estimated Effectiveness of Postpartum Maternal Messenger RNA COVID-19 Vaccination Against Delta and Omicron SARS-CoV-2 Infection and Hospitalization in Infants Younger Than 6 Months
SCJ Jorgenson et al, JAMA Pediatrics, February 27, 2023
(Posted: Feb 27, 2023 11AM)
Postpartum maternal COVID-19 vaccination was moderately effective against Delta infection in infants younger than 6 months but conferred little protection against Omicron. Indirect comparisons suggest postpartum maternal COVID-19 vaccination may be inferior to maternal vaccination during pregnancy, particularly against Omicron.
Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns
CL Acosta et al, JAMA Network Open, February 24, 2023
(Posted: Feb 24, 2023 11AM)
Is exposure to gestational diabetes, gestational hypertension, or preeclampsia associated with biological gestational age, measured via epigenetic clocks, in newborns? In this national multisite cohort study of 1801 children, preeclampsia and gestational diabetes were significantly associated with decelerated gestational age in exposed offspring at birth vs unexposed offspring (ie, they were estimated to be biologically younger than their chronological gestational age), and these associations were more pronounced in female offspring. No associations were observed for gestational hypertension and accelerated or decelerated biological age.
Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease.
Bilal Rayes et al. JAMA network open 2023 2 (2) e230034
(Posted: Feb 18, 2023 8AM)
Is there evidence for an association between hypertensive disorders of pregnancy (HDPs) and long-term risk of cardiovascular disease? In this large genome-wide genetic association study using mendelian randomization, HDPs were associated with higher risk of coronary artery disease and ischemic stroke but not heart failure or atrial fibrillation. Mediation analysis revealed a partial attenuation of the association between HDPs and coronary artery disease after adjustment for systolic blood pressure and type 2 diabetes. These results support the consideration of HDPs as potential risk factors for cardiovascular disease.
Maternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design study.
Sarah C J Jorgensen et al. BMJ (Clinical research ed.) 2023 2 e074035
(Posted: Feb 12, 2023 7AM)
Maternal covid-19 vaccination with a second dose during pregnancy was highly effective against delta and moderately effective against omicron infection and hospital admission in infants during the first six months of life. A third vaccine dose bolstered protection against omicron. Effectiveness for two doses was highest with maternal vaccination in the third trimester, and effectiveness decreased in infants beyond eight weeks of age.
Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study
TS Hartwig et al, The Lancet, February 2, 2023
(Posted: Feb 03, 2023 7AM)
The cffDNA-based test had a sensitivity for aneuploidy detection of 85% (95% CI 79–90) and a specificity of 93% (95% CI 88–96) compared with direct sequencing of the pregnancy tissue. Among 1000 cffDNA-based test results, 446 (45%) were euploid, 405 (41%) aneuploid, 37 (4%) had multiple aneuploidies, and 112 (11%) were inconclusive. This validation of cffDNA-based testing in pregnancy loss shows the potential and feasibility of the method to distinguish euploid and aneuploid pregnancy loss for improved clinical management and benefit of future reproductive medicine and women's health research.
How Wearable Sensors Can Support the Research on Foetal and Pregnancy Outcomes: A Scoping Review
A Maugeri et al, JPM, January 2023
(Posted: Jan 27, 2023 7AM)
Genomic autopsy to identify underlying causes of pregnancy loss and perinatal death.
Byrne Alicia B et al. Nature medicine 2023 1
(Posted: Jan 20, 2023 6AM)
Pregnancy loss and perinatal death are devastating events for families. We assessed ‘genomic autopsy’ as an adjunct to standard autopsy for 200?families who had experienced fetal or newborn death, providing a definitive or candidate genetic diagnosis in 105?families. Our cohort provides evidence of severe atypical in utero presentations of known genetic disorders and identifies novel phenotypes and disease genes. Inheritance of 42% of definitive diagnoses were either autosomal recessive (30.8%), X-linked recessive (3.8%) or autosomal dominant (excluding de novos, 7.7%), with risk of recurrence in future pregnancies.
Multi-omics signatures of the human early life exposome
L Maitre et al, Nature Comm, November 21, 2022
(Posted: Nov 21, 2022 8AM)
In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes.
Effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy: a national observational study in Israel.
Guedalia Joshua et al. Nature communications 2022 11 (1) 6961
(Posted: Nov 16, 2022 8AM)
Compared with the second dose, the third dose effectively prevents overall hospitalizations with SARS-CoV-2 infections, with estimated effectiveness of 92% (95% CI 83–96%) during Delta, and enhances protection against significant disease during Omicron, with effectiveness of 92% (95% CI 26–99%), and 48% (95% CI 37–57%) effectiveness against hospitalization overall. A third dose of the BNT162b2 mRNA COVID-19 vaccine during pregnancy, given at least 5 months after the second vaccine dose, enhances protection against adverse COVID-19-related outcomes.
Association of Patient and Site-of-Care Characteristics With Reproductive Carrier Screening Timing in a Large Integrated Health System
LE Hull et al, JAMA Network Open, November 8, 2022
(Posted: Nov 08, 2022 0PM)
Are site of care, clinician, and patient-specific factors associated with differences in whether reproductive genetic carrier screening was ordered prior to vs during pregnancy across a health care system? This cross-sectional study of 6509 patients who completed carrier screening ordered across the Mass General Brigham integrated health care system in Boston, Massachusetts, including 4 hospitals, 32 clinical sites, and 161 ordering clinicians, from October 1, 2018, through September 30, 2019, found that most (63%) had prenatal screening. Clinician specialty was associated with the greatest variation in timing among observed characteristics.
Current challenges in hemophilia genetics and how they can be overcome
JM Johnson, Nat Cardiovasc Research, October 2022
(Posted: Nov 04, 2022 11AM)
Genomic sequencing in hemophilia is a high-yield test and clinically useful for diagnosis, assessing the risk of developing neutralizing antibodies (‘inhibitors’) against the affected coagulation factor, pregnancy and neonatal management, and family counseling. New genomic technologies can detect several types of DNA change with high sensitivity. Systematic collection of genotype–phenotype data is important to better understand the genetics of hemophilia.
Preeclampsia, Genomics and Public Health
E Dawson et al, CDC Blog Post, October 25, 2022
(Posted: Oct 25, 2022 10AM)
Preeclampsia is estimated to occur in 5 to 7 percent of all pregnancies and is one of the leading causes of maternal morbidity. Risk factors for preeclampsia include first pregnancy; history of preeclampsia; history of hypertension, chronic kidney disease, or both; history of thrombophilia (a condition that increases risk of blood clots); pregnancy from in vitro fertilization; family history of preeclampsia. A recent study identified a cell free RNA (cfRNA) signature that was promising in predicting pre-eclampsia several weeks before the onset of symptoms.
Rapid Nanopore Sequencing–Based Screen for Aneuploidy in Reproductive Care
S Wei et al, NEJM, August 18, 2022
(Posted: Aug 17, 2022 5PM)
Aneuploid pregnancies are a major cause of pregnancy loss, fetal structural anomalies, and developmental delays. Consequently, the identification of genetic abnormalities is an important component of prenatal and fertility care. We developed and validated a new short-read–based approach for library preparation, sequencing, and data analysis that enables accurate, inexpensive, and same-day genomewide aneuploidy detection with the use of a palm-sized, nanopore-based DNA sequencer.
Safety of mRNA COVID-19 vaccines during pregnancy
S Ellington, Lancet, August 11, 2022
(Posted: Aug 14, 2022 11AM)
New findings are consistent with and add to the growing body of evidence that COVID-19 mRNA vaccines are safe during pregnancy. In the USA, data from several vaccine safety monitoring systems, including the Vaccine Adverse Event Report System (VAERS), v-safe, the v-safe COVID-19 Vaccine Pregnancy Registry, and the Vaccine Safety Datalink, have similarly not detected any safety concerns for people who received an mRNA COVID-19 vaccine in pregnancy or for their infants
Covid-19 vaccination in pregnancy.
Badell Martina L et al. BMJ (Clinical research ed.) 2022 8 e069741
(Posted: Aug 14, 2022 11AM)
Cost-effectiveness frameworks for comparing genome and exome sequencing versus conventional diagnostic pathways: A scoping review and recommended methods.
Ferket Bart S et al. Genetics in medicine : official journal of the American College of Medical Genetics 2022 7
(Posted: Jul 15, 2022 5AM)
We recommend the following considerations for each clinical scenario. For prenatal testing, performing comparative analyses of costs of ES strategies and postpartum care, as well as genetic diagnoses and pregnancy outcomes. For early diagnosis in pediatrics, modeling quality-adjusted life years (QALYs) and costs over =20 years for rapid turnaround GS/ES. For hereditary cancer syndrome testing, modeling cumulative costs and QALYs for the individual tested and first/second/third-degree relatives. For tumor profiling, not restricting to treatment uptake or response and including QALYs and costs of downstream outcomes. For screening, modeling lifetime costs and QALYs and considering consequences of low penetrance and GS/ES reanalysis.
Evaluation of Acute Adverse Events after Covid-19 Vaccination during Pregnancy.
DeSilva Malini et al. The New England journal of medicine 2022 6
(Posted: Jun 23, 2022 9AM)
Medically attended acute adverse events after Covid-19 vaccination immediately preceding or during pregnancy were uncommon. Covid-19 vaccines were not associated with an increased risk of the clinically serious acute adverse events that were evaluated. The present data add to the growing literature supporting the safety of Covid-19 vaccination during pregnancy.
Covid-19 Vaccination during Pregnancy - Two for the Price of One.
Rasmussen Sonja A et al. The New England journal of medicine 2022 6
(Posted: Jun 23, 2022 9AM)
Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants.
Halasa Natasha B et al. The New England journal of medicine 2022 6
(Posted: Jun 23, 2022 9AM)
We used a case–control test-negative design to assess the effectiveness of maternal vaccination during pregnancy against hospitalization for Covid-19 among infants younger than 6 months of age. A total of 537 case infants (181 of whom had been admitted to a hospital during the delta period and 356 during the omicron period; median age, 2 months) and 512 control infants were enrolled and included in the analyses; 16% of the case infants and 29% of the control infants had been born to mothers who had been fully vaccinated against Covid-19 during pregnancy. The effectiveness of maternal vaccination against hospitalization for Covid-19 among infants was 52% (95% confidence interval [CI], 33 to 65) overall, 80% (95% CI, 60 to 90) during the delta period, and 38% (95% CI, 8 to 58) during the omicron period. Effectiveness was 69% (95% CI, 50 to 80) when maternal vaccination occurred after 20 weeks of pregnancy and 38% (95% CI, 3 to 60) during the first 20 weeks of pregnancy.
Improving preeclampsia risk prediction by modeling pregnancy trajectories from routinely collected electronic medical record data
S Li et al, NPJ Digital Medicine, June 6, 2022
(Posted: Jun 06, 2022 7AM)
We assessed whether information routinely collected in electronic medical records (EMR) could enhance the prediction of preeclampsia risk beyond what is achieved in standard of care assessments. We developed a digital phenotyping algorithm to curate 108,557 pregnancies from EMRs across the Mount Sinai Health System, accurately reconstructing pregnancy journeys and normalizing these journeys across different hospital EMR systems. We then applied machine learning approaches to a training dataset (N?=?60,879) to construct predictive models of preeclampsia across three major pregnancy time periods (ante-, intra-, and postpartum). The resulting models predicted preeclampsia with high accuracy across the different pregnancy periods, with areas under the receiver operating characteristic curves (AUC) of 0.92, 0.82, and 0.89 at 37 gestational weeks, intrapartum and postpartum, respectively.
Safety of COVID-19 Vaccines During Pregnancy: A Systematic Review and Meta-Analysis
A Ciapponi et al, SSRN, April 1, 2022
(Posted: Apr 04, 2022 2PM)
We retrieved 8,837 records from the search strategy; 71 studies (61 clinical and 10 non-clinical studies, involving 17,719,495 pregnant persons and 389 pregnant animals, respectively) were included. Most studies (94%) were conducted in high-income countries and were cohort studies (51%). Less than 15% of studies were classified as high risk of bias. We identified nine COVID-19 vaccine studies, two preclinical studies, and seven involving 309,164 pregnant persons, mostly exposed to mRNA vaccines. Neither pregnancy outcomes nor reactogenicity exceeded the expected rates. The only exception was postpartum hemorrhage after COVID-19 vaccination reported by two studies. In conclusion, we found no safety concerns for currently administered COVID-19 vaccines during pregnancy.
Grandmaternal smoking during pregnancy is associated with differential DNA methylation in peripheral blood of their grandchildren
SM Watkins et al, EJHG, March 28, 2022
(Posted: Mar 29, 2022 7AM)
We show for the first time that DNAm at a small number of loci in cord blood is associated with grandmaternal smoking in humans. In adolescents we see suggestive associations in regions of the genome which we hypothesised a priori could be involved in transgenerational transmission - we observe sex-specific associations at two sites on the X chromosome and one in an imprinting control region. All are within transcription factor binding sites (TFBSs), and we observe enrichment for TFBS among the CpG sites with the strongest associations.
Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes
MC Magnus et al, JAMA, March 24, 2022
(Posted: Mar 27, 2022 7AM)
Is SARS-CoV-2 vaccination during pregnancy associated with adverse pregnancy outcomes? In this population-based retrospective cohort study that included 157 521 deliveries in Sweden and Norway, SARS-CoV-2 vaccination during pregnancy, compared with no SARS-CoV-2 vaccination during pregnancy, was not significantly associated with risk of preterm birth (adjusted hazard ratio [aHR], 0.98), stillbirth (aHR, 0.86), small for gestational age (adjusted odds ratio [aOR], 0.97), low Apgar score (aOR, 0.97), or neonatal care admission (aOR, 0.97).
Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes
DB Fell et al, JAMA, March 24, 2022
(Posted: Mar 27, 2022 7AM)
Is COVID-19 vaccination during pregnancy associated with adverse peripartum outcomes? In this population-based retrospective cohort study of 97?590 individuals in Ontario, Canada, COVID-19 vaccination during pregnancy, compared with vaccination after pregnancy and with no vaccination, was not significantly associated with increased risk of postpartum hemorrhage, chorioamnionitis, cesarean delivery, admission to neonatal intensive care unit, or low newborn 5-minute Apgar score.
COVID-19 mRNA Vaccines During Pregnancy- New Evidence to Help Address Vaccine Hesitancy
EO Kharbanda et al, JAMA, March 24, 2022
(Posted: Mar 27, 2022 7AM)
Although more than 100 countries recommend COVID-19 vaccination during pregnancy,4 COVID-19 vaccination in pregnant people has lagged behind that for age-matched, nonpregnant adults. In this issue of JAMA, 2 population-based observational retrospective studies evaluating outcomes in more than 250?000 pregnancies from 3 countries together provide the strongest evidence to date regarding the safety of COVID-19 vaccines in pregnancy.
COVID-19 Cases and Disease Severity in Pregnancy and Neonatal Positivity Associated With Delta (B.1.617.2) and Omicron (B.1.1.529) Variant Predominance
EH Adhikari et al, JAMA< March 24, 2022
(Posted: Mar 27, 2022 7AM)
As in nonpregnant people, Delta and Omicron variant predominance were associated with increased SARS-CoV-2 infections in pregnancy, with the majority occurring in unvaccinated individuals. Delta variant predominance was associated with increased illness severity and Omicron with decreased illness severity after adjusting for prior vaccination. The majority of early neonatal SARS-CoV-2 infections occurred among unvaccinated mothers with nonsevere COVID-19. Long-term risks of early neonatal SARS-CoV-2 infection are unknown, but maternal vaccination may be protective.
5 Things to Know About Heart Defects
CDC, February 2022
(Posted: Feb 15, 2022 3PM)
Heart defects are the most common type of birth defect, affecting nearly 1% of births – or about 40,000 births – per year in the United States. It is estimated that more than two million people in the United States are living with heart defects. Some heart defects can be found during pregnancy by looking at ultrasound pictures of the heart of the developing baby. Other heart defects aren’t detected until birth through newborn screening, or later in life, during childhood or adulthood. Screening newborns for heart defects allows them to be treated early and may prevent other health problems or early death. A CDC study found that, as of 2018, all 50 states and Washington, D.C. have newborn screening programs that test for critical congenital heart defects.
Early prediction of preeclampsia in pregnancy with cell-free RNA
MN Moufaraj et al, Nature, February 9, 2022
(Posted: Feb 10, 2022 8AM)
Here we used 404 blood samples from 199 pregnant mothers to identify and validate cfRNA transcriptomic changes that are associated with preeclampsia, a multi-organ syndrome that is the second largest cause of maternal death globally5. We find that changes in cfRNA gene expression between normotensive and preeclamptic mothers are marked and stable early in gestation, well before the onset of symptoms. These changes are enriched for genes specific to neuromuscular, endothelial and immune cell types and tissues that reflect key aspects of preeclampsia physiology.
NIPT and the concerns regarding ‘routinisation’
R Horn, EJHG, February 7, 2022
(Posted: Feb 07, 2022 0PM)
Despite NIPT’s advantages, offering the test as a public health service raises important ethical questions. One major concern is that NIPT could become routinised, as ‘just another pregnancy test’ and that this risks further undermining reproductive autonomy, a risk that has been associated with genetic prenatal testing for many decades. The concern is that routinisation of NIPT could affect the level of informed choice.
A blood test to predict pre‑eclampsia
K O'Leary, Nature Medicine, January 2022
(Posted: Jan 27, 2022 10AM)
Pre-eclampsia is characterized by the onset of maternal high blood pressure in the later stages of pregnancy, and is a major driver of maternal morbidity and mortality — but clinicians have no reliable way to predict (and thereby prevent) its onset. Circulating cell-free RNA (cfRNA) in maternal blood can provide information on fetal gene expression (and therefore development) during pregnancy. A new study identified a cfRNA signature that predicted pre-eclampsia several weeks before the onset of symptoms, with a positive predictive value of 32% (compared with <5% for current methods) and 75% sensitivity.
COVID vaccines safely protect pregnant people: the data are in
S Hall, Nature, January 12, 2022
(Posted: Jan 16, 2022 7AM)
When the vaccines were first administered to the public in late 2020, little was known about their effect on pregnant people, who hadn’t been represented in the original clinical trials that tested the shots. Although that is standard practice, it left pregnant people grappling with whether getting a jab was the best decision for themselves and their babies. But the data are now solid. They show that the risks of COVID-19 during pregnancy — including maternal death, stillbirth and premature delivery — far outweigh the risks of being vaccinated. And yet, according to data from the US Centers for Disease Control and Prevention (CDC), only around 40% of pregnant people in the United States had been vaccinated against COVID-19 by 1 January 2022.
Maternal and early life exposures and their potential to influence development of the microbiome
EE Bolte et al, Genome Medicine, January 11, 2022
(Posted: Jan 11, 2022 8AM)
Studies suggest that modifications to our metagenome and/or microbiome occur following certain environmental exposures during pregnancy and lactation, which in turn render risk of childhood and adult diseases. In this review, we will consider the evidence suggesting that development of the offspring microbiome may be vulnerable to maternal exposures, including an analysis of the data regarding the presence or absence of a low-biomass intrauterine microbiome.
RNA profiles reveal signatures of future health and disease in pregnancy
M Rasmussen et al, Nature, January 7, 2022
(Posted: Jan 08, 2022 7AM)
We show that cfRNA signatures from a single blood draw can track pregnancy progression at the placental, maternal and fetal levels and can robustly predict pre-eclampsia, with a sensitivity of 75% and a positive predictive value of 32.3% (s.d., 3%), which is superior to the state-of-the-art method2. cfRNA signatures of normal pregnancy progression and pre-eclampsia are independent of clinical factors, such as maternal age, body mass index and race,
Awareness of Birth Defects Across the Lifespan
CDC, January 3, 2022
(Posted: Jan 06, 2022 8AM)
Awareness of birth defects across the lifespan helps provide individuals, parents, and families affected by birth defects the information they need to seek proper care. It also gives healthcare professionals the evidence they need to deliver the best care for patients across all stages of life: before and during pregnancy, and in infancy, childhood, adolescence, and adulthood.
Receipt of COVID-19 Vaccine During Pregnancy and Preterm or Small-for-Gestational-Age at Birth — Eight Integrated Health Care Organizations, United States, December 15, 2020–July 22, 2021
HS Lipkind et al, MMWR, January 4, 2022
(Posted: Jan 04, 2022 2PM)
Pregnant women with COVID-19 are at increased risk for severe illness and adverse birth outcomes, yet many remain reluctant to be vaccinated. In a retrospective cohort of >40,000 pregnant women, COVID-19 vaccination during pregnancy was not associated with preterm birth or small-for-gestational-age at birth overall, stratified by trimester of vaccination, or number of vaccine doses received during pregnancy, compared with unvaccinated pregnant women.
V-safe and Registry Monitoring People Who Report Pregnancy
CDC, December 7, 2021
(Posted: Dec 08, 2021 8AM)
As of December 6, 2021, more than 178 thousand v-safe participants have indicated they were pregnant at the time they received COVID-19 vaccination. CDC is currently enrolling eligible participants and analyzing data to better understand how COVID-19 vaccination affects pregnant people. As CDC learns more about the effects of vaccination during pregnancy, data will be presented at the Advisory Committee on Immunization Practices (ACIP) meetings, which are open to the public, and in published reports.
Association between maternal depression during pregnancy and newborn DNA methylation
E Drzymalla et al, Trans Psychiatry, November 9, 2021
(Posted: Nov 10, 2021 9AM)
Waning of the Humoral Response to SARS-CoV-2 in Pregnancy is Variant-Dependent
R Plitman et al, MEDRXIV, November 3, 2021
(Posted: Nov 04, 2021 0PM)
Covid-19 Vaccination during Pregnancy and First-Trimester Miscarriage.
Magnus Maria C et al. The New England journal of medicine 2021 10
(Posted: Oct 21, 2021 6AM)
Our study found no evidence of an increased risk for early pregnancy loss after Covid-19 vaccination and adds to the findings from other reports supporting Covid-19 vaccination during pregnancy. Among 13,956 women with ongoing pregnancies (of whom 5.5% were vaccinated) and 4521 women with miscarriages (of whom 5.1% were vaccinated), the median number of days between vaccination and miscarriage or confirmation of ongoing pregnancy was 19 (Fig. S2). Among women with miscarriages, the adjusted odds ratios for Covid-19 vaccination were 0.91 (95% confidence interval [CI], 0.75 to 1.10) for vaccination in the previous 3 weeks and 0.81 (95% CI, 0.69 to 0.95) for vaccination in the previous 5 weeks.
Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion.
Zauche Lauren H et al. The New England journal of medicine 2021 9 (16) 1533-1535
(Posted: Oct 14, 2021 6AM)
A total of 2456 participants who were enrolled in the CDC v-safe Covid-19 pregnancy registry met the inclusion criteria for this study. Our findings suggest that the risk of spontaneous abortion after mRNA Covid-19 vaccination either before conception or during pregnancy is consistent with the expected risk of spontaneous abortion; these findings add to the accumulating evidence about the safety of mRNA Covid-19 vaccination in pregnancy.
The maternal microbiome: another bridge linking mothers and infants
Ebiomedicine editorial, September 30, 2021,
(Posted: Oct 01, 2021 7AM)
A total of 10–100 trillion microbes live symbiotically within each human host and are thought to affect our physical and mental health. The health effects are thought to begin as early as the gestational period. Research shows that maternal gut microbes may have both direct and indirect effects during pregnancy.
What is a ‘serious’ genetic condition? The perceptions of people living with genetic conditions
FK Boardman et al, EJHG, September 27, 2021
(Posted: Sep 28, 2021 6AM)
This study explores the concept of seriousness through the perspectives of people with a range of ‘clinically serious’ conditions (fragile X conditions, spinal muscular atrophy, cystic fibrosis, hemophilia, thalassemia). Attitudes towards suffering, quality of life (QoL) and selective pregnancy termination were elucidated from 45 in-depth qualitative interviews and 469 postal/online surveys. The majority of participants reported good health/wellbeing, and the capacity for good QoL, despite experiencing suffering with their condition.
Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy
EO Kharbanda et al, JAMA, September 8, 2021
(Posted: Sep 08, 2021 11AM)
Of 105?446 unique pregnancies, 13?160 spontaneous abortions and 92?286 ongoing pregnancies were identified. Overall, 7.8% of women received 1 or more BNT162b2 (Pfizer-BioNTech) vaccines; 6.0% received 1 or more mRNA-1273 (Moderna) vaccines; and 0.5% received an Ad26.COV.2.S (Janssen) vaccine during pregnancy and before 20 weeks’ gestation. Spontaneous abortions did not have an increased odds of exposure to a COVID-19 vaccination in the prior 28 days compared with ongoing pregnancies (adjusted odds ratio, 1.02; 95% CI, 0.96-1.08). Results were consistent for mRNA-1273 and BNT162b2 and by gestational age group.
Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy
N Dagan et al, Nature Medicine, September 7, 2021
(Posted: Sep 07, 2021 6AM)
A total of 10,861 vaccinated pregnant women were matched to 10,861 unvaccinated pregnant controls using demographic and clinical characteristics. Study outcomes included documented infection with SARS-CoV-2, symptomatic COVID-19, COVID-19-related hospitalization, severe illness and death. Estimated vaccine effectiveness from 7 through to 56?d after the second dose was 96% (95% confidence interval 89–100%) for any documented infection, 97% (91–100%) for infections with documented symptoms and 89% (43–100%) for COVID-19-related hospitalization.
Screening for autosomal recessive and X-linked conditions during pregnancy and preconception: a practice resource of the American College of Medical Genetics and Genomics (ACMG).
Gregg Anthony R et al. Genetics in medicine : official journal of the American College of Medical Genetics 2021 7
(Posted: Jul 22, 2021 7AM)
Carrier screening began 50 years ago with screening for conditions that have a high prevalence in defined racial/ethnic groups (e.g., Tay-Sachs disease in the Ashkenazi Jewish population; sickle cell disease in Black individuals). Cystic fibrosis was the first medical condition for which panethnic screening was recommended, followed by spinal muscular atrophy. Next-generation sequencing allows low cost and high throughput identification of sequence variants across many genes simultaneously.
Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons
TT Shimabukuru et al, NEJM< June 17, 2021
(Posted: Jun 16, 2021 7PM)
Among 3958 participants enrolled in the v-safe pregnancy registry, 827 had a completed pregnancy, of which 115 (13.9%) resulted in a pregnancy loss and 712 (86.1%) resulted in a live birth (mostly among participants with vaccination in the third trimester). Adverse neonatal outcomes included preterm birth (in 9.4%) and small size for gestational age (in 3.2%); no neonatal deaths were reported.
Maternal prenatal gut microbiota composition predicts child behaviour
SL Dawson et al, Ebiomedicine, June 4, 2021
(Posted: Jun 06, 2021 7AM)
We found evidence that the alpha diversity of the maternal fecal microbiota during the third trimester of pregnancy predicts child internalizing behavior at two years of age (-2·74, (-4·71, -0·78), p = 0·01 (Wald test), R2=0·07).
Understanding Pregnancy Loss, Infertility, Birth Defects and the MTHFR gene: What Everyone Should Know
J Gunter, the Vajenda, March 27, 2021
(Posted: Mar 29, 2021 6AM)
Many people have erroneously linked MTHFR polymorphisms with a myriad of medical conditions. In the world of reproductive medicine, it is blamed for a host of things, such as infertility, miscarriages, stillbirths, failure of in vitro fertilization (IVF), preecplampsia (a serious medical condition during pregnancy), and having a child with autism, Down syndrome, birth defects that impact the heart (congenital heart disease), and neural tube defects.
Application of Copy Number Variation Sequencing in Genetic Analysis of Miscarriages in Early and Middle Pregnancy.
Luo Shiqiang et al. Cytogenetic and genome research 2021 1-9
(Posted: Mar 26, 2021 9AM)
An abnormal chromosome number is the most important reason for embryo termination in early and middle pregnancy, followed by pathogenic chromosome CNVs. CNV-seq can quickly and accurately detect chromosome abnormalities and identify microdeletion and microduplication CNVs that cannot be detected by conventional chromosome analysis, which is convenient and efficient for genetic etiology diagnosis in miscarriage.
Pregnancy and COVID: what the data say - Pregnant women fare worse than others, although the risks to the fetus are slight.
S Subaraman, Nature News, March 9, 2021
(Posted: Mar 09, 2021 10AM)
Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection - Surveillance for Emerging Threats to Mothers and Babies Network, 20 state, local, and territorial health departments, March 29, 2020 -January 8, 2021
RR Galang et al, MEDRXIV, March 1, 2021
(Posted: Mar 02, 2021 8AM)
Among 5,963 pregnant women with SARS-CoV-2 infection, moderate-to-severe or critical COVID-19 illness was associated with age 30-39 years, Black/Non-Hispanic race/ethnicity, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, cardiovascular disease, pregestational diabetes mellitus or gestational diabetes. Risk of moderate-to-severe or critical illness increased with the number of underlying medical or pregnancy-related conditions.
National Birth Defects Prevention Month Digital Toolkit
CDC, January 2021
(Posted: Dec 29, 2020 8AM)
January is National Birth Defects Prevention Month. Join the nationwide effort to raise awareness of birth defects and their impact on families! Join CDC in sharing information on ways to plan for a healthy pregnancy and prevent birth defects with your patients, family, friends, and followers.
Recurrent pregnancy loss
E Dimitriadis et al, Nature DIs Primers, December 2020
(Posted: Dec 21, 2020 7AM)
Recurrent pregnancy loss can be caused by chromosomal errors, anatomical uterine defects, autoimmune disorders and endometrial dysfunction. Available treatments target the putative risk factors of pregnancy loss, although the effectiveness of many medical interventions is controversial.
Birth and Infant Outcomes Following Laboratory-Confirmed SARS-CoV-2 Infection in Pregnancy — SET-NET, 16 Jurisdictions, March 29–October 14, 2020
KR Woodworth et al, MMWR, November 2, 2020
(Posted: Nov 03, 2020 7AM)
Exome sequencing analysis on products of conception: a cohort study to evaluate clinical utility and genetic etiology for pregnancy loss
C Zhao et al, Genetics in Medicine, October 26, 2020
(Posted: Oct 26, 2020 9AM)
Pregnancy loss ranging from spontaneous abortion (SAB) to stillbirth can result from monogenic causes of Mendelian inheritance. This study evaluated the clinical application of exome sequencing (ES) in identifying the genetic etiology for pregnancy loss.
Investigating the Impact of COVID-19 during Pregnancy
CDC, October 9, 2020
(Posted: Oct 10, 2020 7AM)
Based on what is known at this time, pregnant people might be at an increased risk for severe illness from COVID-19 compared to non-pregnant people. Additionally, pregnant people with COVID-19 might have an increased risk of adverse pregnancy outcomes, such as preterm birth.
A Systematic Review and Meta-analysis of Pregnancy and COVID-19: Signs and Symptoms, Laboratory Tests and Perinatal Outcomes
H Hassanipour et al, MEDRXIV, September 28, 2020
(Posted: Sep 29, 2020 8AM)
What is the meaning of a 'genomic result' in the context of pregnancy?
Shkedi-Rafid Shiri et al. European journal of human genetics : EJHG 2020 Sep
(Posted: Sep 16, 2020 10AM)
As professional organizations develop guidelines on the use of genomic testing during pregnancy, we highlight the difficulties of discovering variants with uncertain clinical significance, and susceptibility to adult-onset diseases. We aim to foster international discussions about how decisions on disclosure are made and how uncertainty is communicated.
Data on COVID-19 during Pregnancy
CDC, August 2020
(Posted: Aug 28, 2020 8AM)
A recent study suggests that pregnant women with COVID-19 are more likely to be hospitalized and are at increased risk for intensive care unit (ICU) admission and receipt of mechanical ventilation than nonpregnant women. Risk of death is similar for both groups. But much remains unknown.
The association of alcohol polygenic risk scores with mental health outcomes: A multi-generational analysis in the Avon Longitudinal Study of Parents and Children
KE Easey et al, MEDRXIV, July 7, 2020
(Posted: Jul 08, 2020 6AM)
An alcohol PRS derived from GWAS of alcohol use in the general population was shown to be associated with frequency and amount of alcohol consumed during pregnancy, and maternal depression at 32 weeks gestation.
High Blood Pressure During Pregnancy
CDC, May 2020
(Posted: May 20, 2020 8AM)
You are more at risk for preeclampsia if: This is the first time you have given birth; You had preeclampsia during a previous pregnancy; You have chronic (long-term) high blood pressure, chronic kidney disease, or both; You have a history of thrombophilia (a condition that increases risk of blood clots); You have a family history of preeclampsia.
With Crispr, a Possible Quick Test for the Coronavirus: A pioneer of the gene-editing technology has devised a diagnostic test for the infection that could be as simple as a pregnancy test.
C Zimmer, NY Times, May 5, 2020
(Posted: May 05, 2020 0PM)
Genetic profile may predict chance of type 2 diabetes among women with gestational diabetes
NIH News Release, February 13, 2020
(Posted: Feb 14, 2020 8AM)
Women who go on to develop type 2 diabetes after having gestational, or pregnancy-related, diabetes are more likely to have particular genetic profiles. The findings provide insight into the genetic factors underlying the risk of type 2 diabetes and may inform strategies for reducing this risk among women who had gestational diabetes.
Deep phenotyping during pregnancy for predictive and preventive medicine
AG Paquette et al, Scit Trans Medicine, Januar 22, 2020
(Posted: Jan 24, 2020 8AM)
Systems biology offers a holistic approach to deciphering physiology or disease by deriving and integrating biological information to delineate relevant networks and their dynamics. We discuss why pregnancy is particularly well suited for prototyping deep phenotyping, scientific wellness, and related systems biology approaches to predictive medicine.
Folic Acid Information
CDC, January 2020
(Posted: Jan 05, 2020 11AM)
Folic acid is a B vitamin. If a woman has enough folic acid in her body before and during pregnancy, it can help prevent major birth defects of the baby’s brain and spine. Women need 400 micrograms (mcg) of folic acid every day.
Mom’s immune system and microbiome may help predict premature birth
A Keener, Science News, November 8, 2019
(Posted: Nov 10, 2019 8AM)
Putting it all together, the team developed an “immune clock” of pregnancy — a mathematical model that links the many immune parameters with how far along a pregnancy is. The model, reported in 2017 in Science Immunology, accurately estimated the gestational ages of a new set of 10 pregnancies.
Maternal microbiota in pregnancy and early life
B McDonald et al, Sci Trans Medicine, September 2019
(Posted: Sep 19, 2019 9AM)
Maternal Vaccines: Part of a Healthy Pregnancy
CDC, 2019
(Posted: Aug 08, 2019 9AM)
Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.
Serrano Myrna G et al. Nature medicine 2019 May
(Posted: Jun 03, 2019 9AM)
Genetic Testing and Pregnancy Outcome Analysis of 362 Fetuses with Congenital Heart Disease Identified by Prenatal Ultrasound.
Luo Shiyu et al. Arquivos brasileiros de cardiologia 2018 Aug
(Posted: Aug 29, 2018 10AM)
Do patients who achieve pregnancy using IVF-PGS do the recommended genetic diagnostic testing in pregnancy?
Kimelman Dana et al. Journal of assisted reproduction and genetics 2018 Aug
(Posted: Aug 22, 2018 11AM)
Clinical and Economic Impact of Adopting Noninvasive Prenatal Testing as a Primary Screening Method for Fetal Aneuploidies in the General Pregnancy Population.
Kostenko Emilia et al. Fetal diagnosis and therapy 2018 Aug 1-11
(Posted: Aug 22, 2018 11AM)
Sequencing of Circulating Cell-free DNA during Pregnancy.
Bianchi Diana W et al. The New England journal of medicine 2018 Aug (5) 464-473
(Posted: Aug 02, 2018 8AM)
Making Pregnancy Safer
M Humphrey, Frontline Genomics, July 9, 2018
(Posted: Jul 14, 2018 10AM)
Blood Test Might Predict Pregnancy Due Date and Preterm Birth
P Belluck, New York Times, June 7, 2018
(Posted: Jun 08, 2018 8AM)
Schizophrenia risk genes are not so risky if the mothers pregnancy was healthy
S Begley, Stat News, May 28, 2018
(Posted: May 29, 2018 11AM)
Familial Hypercholesterolemia and Pregnancy
G Lundberg et al, Am College Cardiology, May 14, 2018
(Posted: May 16, 2018 8AM)
Recognizing the Global Impact of Zika Virus Infection during Pregnancy.
Honein Margaret A et al. The New England journal of medicine 2018 Mar (11) 1055-1056
(Posted: Mar 15, 2018 8AM)
Genetic and epigenetic variations associated with idiopathic recurrent pregnancy loss.
Arias-Sosa Luis Alejandro et al. Journal of assisted reproduction and genetics 2018 Jan
(Posted: Feb 26, 2018 10AM)
The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser Daniel et al. Obstetrics and gynecology clinics of North America 2018 Mar (1) 143-154
(Posted: Feb 26, 2018 9AM)
Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States
B Fitzgerald et al, JAMA, Jan 25, 2018
(Posted: Jan 26, 2018 9AM)
