20 hot topic(s) found with the query "Preeclampsia"
Researchers one step closer to preventing preeclampsia
Medical XPress, APA, March 14, 2024
(Posted: Mar 18, 2024 3PM)
From the website: "Researchers have identified several differences in DNA methylation in people who experienced preeclampsia during pregnancy, according to a new study from Oregon Health & Science University. The study also revealed these differences appear to occur in connection to genes relevant to the disease. "
Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes: A Mendelian Randomization Study.
Tormod Rogne et al. JAMA Netw Open 2024 1 (1) e2351166
(Posted: Jan 12, 2024 6AM)
From the abstract: " Which pathways mediate the inequity in pregnancy health associated with low educational attainment? In this cohort study of more than 3 million individuals, an association between genetically estimated lower educational attainment and increased risk of ectopic pregnancy, hyperemesis gravidarum, gestational diabetes, preeclampsia, preterm birth, and offspring low birth weight was observed. A sizeable portion of these associations were explained by targetable risk factors. These findings suggest that the association of socioeconomic inequalities with adverse pregnancy outcomes may be reduced by intervening for type 2 diabetes, body mass index, smoking, high-density lipoprotein cholesterol level, and systolic blood pressure."
Cord blood DNA methylation signatures associated with preeclampsia are enriched for cardiovascular pathways: insights from the VDAART trial.
Hanna M Knihtilä et al. EBioMedicine 2023 11 104890
(Posted: Nov 29, 2023 9AM)
From the abstract: "Preeclampsia has been associated with maternal epigenetic changes, in particular DNA methylation changes in the placenta. It has been suggested that preeclampsia could also cause DNA methylation changes in the neonate. We examined DNA methylation in relation to gene expression in the cord blood of offspring born to mothers with preeclampsia. This study included 128 mother-child pairs who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART), where assessment of preeclampsia served as secondary outcome. We found that preeclampsia is related to differential cord blood DNA methylation signatures of cardiovascular pathways, including the apelin signaling pathway. "
Pregnant and Living with Sickle Cell Disease: A Push for Better Outcomes
NIH, September 2023
(Posted: Sep 16, 2023 1PM)
From the website: " Experts say that medical advances in care and disease-modifying therapies have helped many people living with SCD survive well through their reproductive years. For parents-to-be, that means awareness is key. Individuals with SCD are at higher risk than the general population for preeclampsia, as Found discovered; but those with preeclampsia can go on to develop a condition called eclampsia, which can lead to seizures and even coma. People with SCD are also at higher risk for sepsis and blood clots. And there are risks for the fetus, such as lower-than-normal growth in the womb, preterm delivery, and stillbirth."
Using the methylome to predict pre-eclampsia
Tu’uhevaha J. Kaitu’u-Lino et al, Nature Medicine, August 28, 2023
(Posted: Aug 28, 2023 1PM)
From the abstract: "A blood test done in early pregnancy that measures cell-free DNA methylation could represent a novel way to predict the risk of preterm pre-eclampsia. Pre-eclampsia is a serious complication that imperils the lives of women and their unborn babies. Arising in 3–5% of pregnancies, it claims the lives of 60,000 pregnant women every year around the world. For every death, it is estimated that 50–100 women encounter permanent health ailments because of a pre-eclamptic pregnancy; pre-eclampsia is also associated with adverse fetal mortality and morbidity."
Cell-free DNA methylome analysis for early preeclampsia prediction
M de Borre et al, Nature Medicine, August 28, 2023
(Posted: Aug 28, 2023 1PM)
From the abstract: "To identify at-risk pregnancies for preeclampsia (PE), we profiled methylomes of plasma-derived, cell-free DNA from 498?pregnant women, of whom about one-third developed early-onset PE. We detected DNA methylation differences between control and PE pregnancies that enabled risk stratification at PE diagnosis but also presymptomatically, at around 12?weeks of gestation. The first-trimester risk prediction model was validated in an external cohort collected from two centers (area under the curve (AUC)?=?0.75) and integrated with routinely available maternal risk factors (AUC?=?0.85). The combined risk score correctly predicted 72% of patients with early-onset PE at 80% specificity."
Transforming preeclampsia diagnosis: The promising role of cfRNA
News Medical, August 15, 2023
(Posted: Aug 18, 2023 8AM)
Preeclampsia is a serious pregnancy disorder marked by elevated blood pressure and the presence of proteins in urine. It impacts approximately 2% to 4% of expectant mothers worldwide, resulting in approximately 46,000 maternal fatalities and roughly 500,000 deaths of both fetuses and newborns annually.
A recent study illuminates a potential diagnostic avenue for this condition utilizing plasma cell-free RNA (cfRNA).
Polygenic prediction of preeclampsia and gestational hypertension.
Michael C Honigberg et al. Nat Med 2023 5
(Posted: May 30, 2023 6AM)
Here we tested the association of maternal DNA sequence variants with preeclampsia in 20,064 cases and 703,117 control individuals and with gestational hypertension in 11,027 cases and 412,788 control individuals across discovery and follow-up cohorts using multi-ancestry meta-analysis. Altogether, we identified 18 independent loci associated with preeclampsia/eclampsia and/or gestational hypertension, 12 of which are new (for example, MTHFR–CLCN6, WNT3A, NPR3, PGR and RGL3), including two loci (PLCE1 and FURIN) identified in the multitrait analysis.
Analysis of Pregnancy Complications and Epigenetic Gestational Age of Newborns
CL Acosta et al, JAMA Network Open, February 24, 2023
(Posted: Feb 24, 2023 11AM)
Is exposure to gestational diabetes, gestational hypertension, or preeclampsia associated with biological gestational age, measured via epigenetic clocks, in newborns? In this national multisite cohort study of 1801 children, preeclampsia and gestational diabetes were significantly associated with decelerated gestational age in exposed offspring at birth vs unexposed offspring (ie, they were estimated to be biologically younger than their chronological gestational age), and these associations were more pronounced in female offspring. No associations were observed for gestational hypertension and accelerated or decelerated biological age.
Preeclampsia, Genomics and Public Health
E Dawson et al, CDC Blog Post, October 25, 2022
(Posted: Oct 25, 2022 10AM)
Preeclampsia is estimated to occur in 5 to 7 percent of all pregnancies and is one of the leading causes of maternal morbidity. Risk factors for preeclampsia include first pregnancy; history of preeclampsia; history of hypertension, chronic kidney disease, or both; history of thrombophilia (a condition that increases risk of blood clots); pregnancy from in vitro fertilization; family history of preeclampsia. A recent study identified a cell free RNA (cfRNA) signature that was promising in predicting pre-eclampsia several weeks before the onset of symptoms.
Improving preeclampsia risk prediction by modeling pregnancy trajectories from routinely collected electronic medical record data
S Li et al, NPJ Digital Medicine, June 6, 2022
(Posted: Jun 06, 2022 7AM)
We assessed whether information routinely collected in electronic medical records (EMR) could enhance the prediction of preeclampsia risk beyond what is achieved in standard of care assessments. We developed a digital phenotyping algorithm to curate 108,557 pregnancies from EMRs across the Mount Sinai Health System, accurately reconstructing pregnancy journeys and normalizing these journeys across different hospital EMR systems. We then applied machine learning approaches to a training dataset (N?=?60,879) to construct predictive models of preeclampsia across three major pregnancy time periods (ante-, intra-, and postpartum). The resulting models predicted preeclampsia with high accuracy across the different pregnancy periods, with areas under the receiver operating characteristic curves (AUC) of 0.92, 0.82, and 0.89 at 37 gestational weeks, intrapartum and postpartum, respectively.
Early prediction of preeclampsia in pregnancy with cell-free RNA
MN Moufaraj et al, Nature, February 9, 2022
(Posted: Feb 10, 2022 8AM)
Here we used 404 blood samples from 199 pregnant mothers to identify and validate cfRNA transcriptomic changes that are associated with preeclampsia, a multi-organ syndrome that is the second largest cause of maternal death globally5. We find that changes in cfRNA gene expression between normotensive and preeclamptic mothers are marked and stable early in gestation, well before the onset of symptoms. These changes are enriched for genes specific to neuromuscular, endothelial and immune cell types and tissues that reflect key aspects of preeclampsia physiology.
A blood test to predict pre‑eclampsia
K O'Leary, Nature Medicine, January 2022
(Posted: Jan 27, 2022 10AM)
Pre-eclampsia is characterized by the onset of maternal high blood pressure in the later stages of pregnancy, and is a major driver of maternal morbidity and mortality — but clinicians have no reliable way to predict (and thereby prevent) its onset. Circulating cell-free RNA (cfRNA) in maternal blood can provide information on fetal gene expression (and therefore development) during pregnancy. A new study identified a cfRNA signature that predicted pre-eclampsia several weeks before the onset of symptoms, with a positive predictive value of 32% (compared with <5% for current methods) and 75% sensitivity.
High Blood Pressure During Pregnancy
CDC, May 2020
(Posted: May 20, 2020 8AM)
You are more at risk for preeclampsia if: This is the first time you have given birth; You had preeclampsia during a previous pregnancy; You have chronic (long-term) high blood pressure, chronic kidney disease, or both; You have a history of thrombophilia (a condition that increases risk of blood clots); You have a family history of preeclampsia.
Pre-eclampsia: pathophysiology and clinical implications
GJ Burton et al, BMJ, July 16, 2019
(Posted: Jul 16, 2019 8AM)
Pre-eclampsia is a common disorder that particularly affects first pregnancies. There are two sub-types: early and late onset pre-eclampsia, with others almost certainly yet to be identified. Early onset pre-eclampsia arises owing to defective placentation, while late onset pre-eclampsia may center around interactions between normal senescence of the placenta and a maternal genetic predisposition to cardiovascular and metabolic disease.
Updates on Screening, Prevention, Treatment, and Genetic Markers for Preeclampsia.
Palomaki Glenn E et al. Clinical chemistry 2018 Sep
(Posted: Sep 12, 2018 9AM)
Genetic Approaches in Preeclampsia.
Yong Hannah E J et al. Methods in molecular biology (Clifton, N.J.) 2018 53-72
(Posted: May 22, 2018 9AM)
Genetic and non-genetic risk factors for pre-eclampsia: an umbrella review of systematic reviews and meta-analyses of observational studies.
Giannakou Konstantinos et al. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2017 Nov
(Posted: Jan 23, 2018 9AM)
Babies DNA affects mothers risk of pre-eclampsia in pregnancy, study finds
Science Mag, June 19, 2017
(Posted: Jun 19, 2017 2PM)
Antiphospholipid Antibody Syndrome
From NHLBI health topic site
(Posted: Jan 11, 2014 11AM)
What Is
Antiphospholipid (AN-te-fos-fo-LIP-id) antibody syndrome (APS) is an autoimmune disorder. Autoimmune disorders occur if the body's immune system makes antibodies that attack and damage tissues or cells.
Antibodies are a type of protein. They usually help defend the body against infections. In APS, however, the body makes antibodies that mistakenly attack phospholipids?a type of fat.
Phospholipids are found in all living cells and cell membranes, including blood cells and the lining of blood vessels.
When antibodies attack phospholipids, cells are damaged. This damage causes blood clots to form in the body's arteries and veins. (These are the vessels that carry blood to your heart and body.)
Usually, blood clotting is a normal bodily process. Blood clots help seal small cuts or breaks on blood vessel walls. This prevents you from losing too much blood. In APS, however, too much blood clotting can block blood flow and damage the body's organs.
Overview
Some people have APS antibodies, but don't ever have signs or symptoms of the disorder. Having APS antibodies doesn't mean that you have APS. To be diagnosed with APS, you must have APS antibodies and a history of health problems related to the disorder.
APS can lead to many health problems, such as stroke, heart attack, kidney damage, deep vein thrombosis (throm-BO-sis), and pulmonary embolism (PULL-mun-ary EM-bo-lizm).
APS also can cause pregnancy-related problems, such as multiple miscarriages, a miscarriage late in pregnancy, or a premature birth due to eclampsia (ek-LAMP-se-ah). (Eclampsia, which follows preeclampsia, is a serious condition that causes seizures in pregnant women.)
Very rarely, some people who have APS develop many blood clots within weeks or months. This condition is called catastrophic antiphospholipid syndrome (CAPS).
People who have APS also are at higher risk for thrombocytopenia (THROM-bo-si-to-PE-ne-ah). This is a condition in which your blood has a lower than normal number of blood cell fragments called platelets (PLATE-lets). Antibodies destroy the platelets, or they?re used up during the clotting process. Mild to serious bleeding can occur with thrombocytopenia.
APS can be fatal. Death may occur as a result of large blood clots or blood clots in the heart, lungs, or brain.
Outlook
APS can affect people of any age. However, it's more common in women and people who have other autoimmune or rheumatic (ru-MAT-ik) disorders, such as lupus. ("Rheumatic" refers to disorders that affect the joints, bones, or muscles.)
APS has no cure, but medicines can help prevent its complications. Medicines are used to stop blood clots from forming. They also are used to keep existing clots from getting larger. Treatment for APS is long term.
If you have APS and another autoimmune disorder, it's important to control that condition as well. When the other condition is controlled, APS may cause fewer problems.
