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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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4 hot topic(s) found with the query "Occupational exposure"

Commentary on the contributions and future role of occupational exposure science in a vision and strategy for the discipline of exposure science.
Harper Martin et al. J Expo Sci Environ Epidemiol 2015 Feb 11. (Posted: May 20, 2015 2PM)

Increased N7-methyldeoxyguanosine DNA adducts after occupational exposure to pesticides and influence of genetic polymorphisms of paraoxonase-1 and glutathione S-transferase M1 and T1.
Gómez-Martín Antonio et al. Environ. Mol. Mutagen. 2014 Nov 26. (Posted: Mar 15, 2015 1PM)

Metabolic polymorphisms and biomarkers of effect in the biomonitoring of occupational exposure to low-levels of benzene: state of the art.
De Palma G et al. Toxicol. Lett. 2014 Dec 1. (2) 194-204 (Posted: Mar 15, 2015 1PM)

Genetic Susceptibility and Brain Tumors
Brand (Posted: Jan 11, 2014 11AM)

Polymorphisms in genes might modify the effects of exogenous and endogenous carcinogens in brain tumor development. DCEG investigators have evaluated the glutathione-S-transferase and cytochrome P-450 families of genes, both of which encode enzymes involved in the metabolism of solvents and other substrates. Occupational exposure to lead might cause meningioma, and a polymorphism in a gene for an enzyme that influences blood levels of lead [delta-aminolevulinic acid dehydratase, (ALAD)] was positively associated with the risk of meningioma. The association between glioma risk and history of allergies is being explored by examining the relation between glioma risk and polymorphisms in cytokine genes, and polymorphisms in a large panel of genes related to innate immunity also are under study. A recent paper from this study concerning apoptosis and cell cycle control genes identified caspase 8 as a possible susceptibility gene. Analyses concerning polymorphisms in oxidative stress genes, DNA repair genes, and insulin-like growth factor genes are in progress. No single epidemiological study of brain tumors has adequate statistical power to evaluate most gene-environment or gene-gene interactions. An international consortium of brain tumor epidemiological studies (BTEC) was organized so that brain tumor risks associated with genetic susceptibility and specific exposures can be evaluated in the combined studies.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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