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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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48 hot topic(s) found with the query "Longevity"

Educational Mobility, Pace of Aging, and Lifespan Among Participants in the Framingham Heart Study
GH Graaf et al, JAMA Network Open, March 1, 2024 (Posted: Mar 01, 2024 0PM)

From the abstract: " Is upward educational mobility associated with a slower pace of biological aging and increased longevity? In this cohort study of 3101 participants representing 2 generations of the Framingham Heart Study, upward educational mobility was associated with a slower pace of aging (as measured with whole-blood DNA-methylation data) and lower risk of death. Slower pace of aging accounted for approximately half of the association between educational mobility and mortality. These results suggest that interventions to promote educational attainment may slow the pace of biological aging and promote longevity. "

Validation of biomarkers of aging.
Mahdi Moqri et al. Nat Med 2024 2 (Posted: Feb 18, 2024 7AM)

From the abstract: "The search for biomarkers that quantify biological aging (particularly ‘omic’-based biomarkers) has intensified in recent years. Such biomarkers could predict aging-related outcomes and could serve as surrogate endpoints for the evaluation of interventions promoting healthy aging and longevity. However, no consensus exists on how biomarkers of aging should be validated before their translation to the clinic. Here, we review current efforts to evaluate the predictive validity of omic biomarkers of aging in population studies, discuss challenges in comparability and generalizability. "

Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans.
Chao-Jie Ye et al. Nat Hum Behav 2023 6 (Posted: Jul 03, 2023 8AM)

Here we performed two-sample Mendelian randomization analyses applying genetic instruments of education, income and occupation (n?=?248,847 to 1,131,881) to estimate their causal effects and consequences on parental lifespan and self-longevity (n?=?28,967 to 1,012,240) from the largest available genome-wide association studies in populations of European ancestry. Each 4.20 years of additional educational attainment were causally associated with a 3.23-year-longer parental lifespan independently of income and occupation and were causally associated with 30–59% higher odds of self-longevity.

Epigenetic profile of Japanese supercentenarians: a cross-sectional study
S Komaki et al, The Lancet Healthy Longevity, February 2023 (Posted: Feb 03, 2023 7AM)

Epigenome-wide association analyses showed that centenarians and supercentenarians had younger-than-expected epigenetic states (DNA methylation profiles similar to those of non-centenarians) for 557 CpG sites enriched in cancer-related and neuropsychiatric-related genes, whereas these individuals had advanced (or older) epigenetic states for 163 CpG sites represented by genes related to TGF-ß signalling, which is involved in anti-inflammatory responses and known to contribute to healthy ageing.

Diet modulates genetic effects on longevity.
et al. Nature genetics 2023 1 (Posted: Jan 11, 2023 6AM)

Why some individuals live longer than others is of major interest across a range of scientific disciplines, from evolutionary biology to human health. Evolutionary theory tells us that lifespan-reducing alleles should be purged from the gene pool1, yet decades of genome-wide association studies (GWAS) and model organism studies have shown that such alleles persist. Here, we address one potential explanation for this conundrum, the idea that alleles that regulate lifespan do so only in certain contexts (known as ‘genotype-by-environment’ (GxE) effects).

Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women
P Jain et al, JAMA Network Open, July 27, 2022 (Posted: Jul 27, 2022 3PM)

This cohort study was a secondary analysis of 3 Women’s Health Initiative ancillary studies among 1813 women eligible to survive to age 90 years by end of study period. The study found that increased epigenetic age acceleration as measured by 4 epigenetic clocks was associated with lower odds of survival to age 90 years with intact mobility; results were similar when including intact cognitive functioning. Meaning These findings suggest that epigenetic age acceleration may be a useful biomarker to estimate functional and cognitive aging among older women.

Efficacy and longevity of immune response to 3rd COVID-19 vaccine and effectiveness of a 4th dose in severely immunocompromised patients with cancer
A Thakkar et al, MEDRXIV, July 6, 2022 (Posted: Jul 07, 2022 7AM)

Mendelian randomization analysis for attention deficit/hyperactivity disorder: studying a broad range of exposures and outcomes.
Soler Artigas María et al. International journal of epidemiology 2022 6 (Posted: Jun 18, 2022 10AM)

We used genome-wide association study (GWAS) summary statistics for ADHD (n?=?53?293) and 124 traits related to anthropometry, cognitive function and intelligence, early life exposures, education and employment, lifestyle and environment, longevity, neurological, and psychiatric and mental health or personality and psychosocial factors available in the MR-Base database (16?067 =n?=766?345). Our findings strengthen previous evidence of a causal effect of ADHD liability on smoking and major depression, and are consistent with a causal effect on odds of decreased average total household income [odds ratio (OR)?=?0.966, 95% credible interval (CrI)?=?(0.954, 0.979)] and increased lifetime number of sexual partners [OR?=?1.023, 95% CrI?=?(1.013, 1.033)].

Making sense of the ageing methylome.
Seale Kirsten et al. Nature reviews. Genetics 2022 5 (Posted: May 08, 2022 7AM)

Over time, the human DNA methylation landscape accrues substantial damage, which has been associated with a broad range of age-related diseases, including cardiovascular disease and cancer. Various age-related DNA methylation changes have been described, including at the level of individual CpGs, such as differential and variable methylation, and at the level of the whole methylome, including entropy and correlation networks. Here, we review these changes in the ageing methylome as well as the statistical tools that can be used to quantify them. We detail the evidence linking DNA methylation to ageing phenotypes and the longevity strategies aimed at altering both DNA methylation patterns and machinery to extend healthspan and lifespan. Lastly, we discuss theories on the mechanistic causes of epigenetic ageing.

Intensity and longevity of SARS-CoV-2 vaccination response and efficacy of adjusted vaccination schedules in patients with immune-mediated inflammatory disease
D Simon et al, MEDRXIV, April 12, 2022 (Posted: Apr 13, 2022 10AM)

SARS-CoV-2 spike-binding antibody longevity and protection from re-infection with antigenically similar SARS-CoV-2 variants
J Kubale et al, MEDRXIV, March 30, 2022 (Posted: Mar 31, 2022 7AM)

Urinary peptidomic profiles to address age-related disabilities: a prospective population study
DS Martens et al, THe Lancet Healthy Longevity, October 2021 (Posted: Oct 17, 2021 2PM)

The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 called for innovation in addressing age-related disabilities. Our study aimed to identify and validate a urinary peptidomic profile (UPP) differentiating healthy from unhealthy ageing in the general population, to test the UPP predictor in independent patient cohorts, and to search for targetable molecular pathways underlying age-related chronic diseases.

Epigenetic clock: a promising mirror of aging
Z Liu et al, Lancet Healthy Longevity, May 2021 (Posted: May 19, 2021 8AM)

We are witnessing rapid progress in the intersection of aging and epigenetics. With advances in this field, we believe that epigenetic clocks could help answer the ultimate question—what is aging and how does it contribute to disease progression across different populations?

Epigenetic-age acceleration in the emerging burden of cardiometabolic diseases among migrant and non-migrant African populations: a population-based cross-sectional RODAM substudy
FP Chilunga et al, Lancet Healthy Longevity, ay 2021 (Posted: May 19, 2021 8AM)

Achieving healthy human longevity: A global grand challenge
V Dzau et al, Sci Trans Med, October 21, 2020 (Posted: Oct 22, 2020 9AM)

With continued advances in science and technology, there is great potential to improve the health and enrich the lives of older adults. By delaying the deleterious biological processes associated with aging, we could prevent debilitating illness and loss of function associated with aging.

Longevity Gene KLOTHO and Alzheimer Disease—A Better Fate for Individuals Who Carry APOE ε4
DB Dubbal et al, JAMA Neurology, April 13, 2020 (Posted: Apr 14, 2020 0PM)

A new meta-analysis provides strong evidence that individuals who carry APOE4 are not uniformly fated to develop AD and specifically establishes a protective role of KL-VS heterozygosity in the APOE4-AD risk. This work is important because it carries several implications for neurology, clinical trials, and translational research.

Biological age in UK Biobank: biomarker composition and prediction of mortality, coronary heart disease and hospital admissions
MS Chan et al, MedrxIV, December 15, 2019 (Posted: Dec 15, 2019 4PM)

This study identified that markers of impaired function in a range of organs account for a substantial proportion of the apparent effect of age on disease and hospital admissions. It supports a broader, multi-system approach to research and prevention of diseases of ageing

Deep Aging Clocks: The Emergence of AI-Based Biomarkers of Aging and Longevity
A Zhavoronkov et al, Cell, July 3, 2019 (Posted: Jul 05, 2019 11AM)

Predictors of chronological and biological age developed using deep learning (DL) are rapidly gaining popularity in the aging research community. The authors provide a brief overview of recent advances in the important field of aging clocks that have been developed using artificial intelligence, and discuss their potential health applications.

AI Based Predictors of Aging and Longevity Are on the Rise
Genetic Engineering and Biotechnology News, July 5, 2019 (Posted: Jul 05, 2019 11AM)

Exceptional Human Longevity.
Pignolo Robert J et al. Mayo Clinic proceedings 2018 Dec (Posted: Jan 01, 2019 1PM)

Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating.
Ruby J Graham et al. Genetics 2018 Nov (3) 1109-1124 (Posted: Nov 08, 2018 8AM)

The Key to a Long Life Has Little to Do With ‘Good Genes’
M Molteni, WIRED< NOvember 6, 2018 (Posted: Nov 08, 2018 8AM)

Genomic underpinnings of lifespan allow prediction and reveal basis in modern risks
TR Timmers et al, BioRXIV, July 2018 (Posted: Jul 07, 2018 6PM)

World's largest family tree reveals environment’s influence on lifespan
EC Hayden, Nature News, Mar 1, 2018 (Posted: Mar 01, 2018 3PM)

Massive genetic study shows how humans are evolving Analysis of 215,000 people's DNA suggests variants that shorten life are being selected against.
B Martin, Nature News, Sep 7, 2017 (Posted: Sep 07, 2017 3PM)

Identifying genetic variants that affect viability in large cohorts
H Mostafavi et al, PLOS Biology, Sep 2017 (Posted: Sep 06, 2017 6PM)

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.
Giuliani Cristina et al. Mechanisms of ageing and development 2017 Feb (Posted: Jun 19, 2017 9AM)

The genetics of human longevity: an intricacy of genes, environment, culture and microbiome.
Dato Serena et al. Mechanisms of ageing and development 2017 Apr (Posted: Jun 19, 2017 9AM)

Scientists Discover a Key to a Longer Life in Male DNA
C Zimmer, New York Times, June 16, 2017 (Posted: Jun 19, 2017 9AM)

Microbial Genetic Composition Tunes Host Longevity
B Han et al, Cell, June 2017 (Posted: Jun 15, 2017 1PM)

Epigenetic Mechanisms of Longevity and Aging.
Sen Payel et al. Cell 2016 Aug (4) 822-39 (Posted: Feb 26, 2017 4PM)

The genetics of exceptional longevity identifies new druggable targets for vascular protection and repair.
Puca Annibale A et al. Pharmacological research 2016 Dec 169-174 (Posted: Feb 26, 2017 4PM)

A review of the biomedical innovations for healthy longevity.
Moskalev Alexey et al. Aging 2017 Jan (1) 7-25 (Posted: Feb 26, 2017 4PM)

Human longevity: Genetics or Lifestyle? It takes two to tango.
Passarino Giuseppe et al. Immunity & ageing : I & A 2016 12 (Posted: Jul 01, 2016 10AM)

The genetics of exceptional longevity: Insights from centenarians.
Santos-Lozano Alejandro et al. Maturitas 2016 Aug 49-57 (Posted: Jul 01, 2016 10AM)

Human Longevity is Influenced by many Genetic Variants: Evidence from 75,000 UK Biobank Participants
LC Pilling et al, BioxRV, February 2016 (Posted: Feb 22, 2016 10AM)

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity
K Fortney et al, PLOS Genetics, December 17, 2015 (Posted: Dec 17, 2015 8PM)

New genes associated with extreme longevity identified
Medical News Today December 17, 2015 (Posted: Dec 17, 2015 8PM)

IL7R gene expression network associates with human healthy ageing.
Passtoors Willemijn M et al. Immunity & ageing : I & A 2015 21 (Posted: Dec 15, 2015 3PM)

Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes.
Moskalev Alexey et al. Nucleic acids research 2015 Nov (Posted: Dec 15, 2015 3PM)

Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population.
Lin Rong et al. Journal of human genetics 2015 Dec (Posted: Dec 15, 2015 3PM)

Do you think you’ll live to be 100? The answer may be in your genes.
M Cimons, Washington Post, December 15, 2015 (Posted: Dec 15, 2015 3PM)

Mouse models and aging: longevity and progeria.
Liao Chen-Yu et al. Curr. Top. Dev. Biol. 2014 249-85 (Posted: Jun 01, 2015 0PM)

Promoting Health and Longevity through Diet: From Model Organisms to Humans.
Fontana Luigi et al. Cell 2015 Mar 26. (1) 106-118 (Posted: May 01, 2015 9AM)

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake.
Sharples Adam P et al. Aging Cell 2015 Apr 10. (Posted: May 01, 2015 9AM)

Extended fertility and longevity: the genetic and epigenetic link.
Wainer-Katsir Kerem et al. Fertil. Steril. 2015 Mar 18. (Posted: May 01, 2015 9AM)

Longevity: epigenetic and biomolecular aspects.
Taormina Giusi et al. Biomol Concepts 2015 Apr 17. (Posted: Apr 18, 2015 9AM)

Longevity and compression of morbidity from a neuroscience perspective: Do we have a duty to die by a certain age?
Faria Miguel A et al. Surg Neurol Int 2015 49 (Posted: Apr 18, 2015 9AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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