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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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53 hot topic(s) found with the query "Attention deficit hyperactivity disorder"

Connecting clinical and genetic heterogeneity in ADHD.
Chloe X Yap et al. Nat Genet 2024 2 (Posted: Feb 09, 2024 10AM)

From the abstract: "Understanding clinical heterogeneity in attention deficit hyperactivity disorder (ADHD) is important for improving personalized care and long-term outcomes. A recent study exploits the large scale and breadth of phenotyping of the iPSYCH cohort to link clinical heterogeneity to genetic heterogeneity in ADHD. "

Validity of Diagnostic Support Model for Attention Deficit Hyperactivity Disorder: A Machine Learning Approach
KC Chu et al, JPM, October 25, 2023 (Posted: Oct 25, 2023 9AM)

From the abstract: "An accurate and early diagnosis of attention deficit hyperactivity disorder can improve health outcomes and prevent unnecessary medical expenses. This study developed a diagnostic support model using a machine learning approach to effectively screen individuals for attention deficit hyperactivity disorder. Three models were developed: a logistic regression model, a classification and regression tree (CART), and a neural network. The models were assessed by using a receiver operating characteristic analysis. In total, 74 participants were enrolled into the disorder group, while 21 participants were enrolled in the control group. "

FASDetect as a machine learning-based screening app for FASD in youth with ADHD
L Ehrig et al, NPJ Digital Medicine, July 19, 2023 (Posted: Jul 20, 2023 7AM)

Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD in youth with ADHD symptoms. To develop the prediction model, medical record data from a University outpatient unit are assessed including 275 patients aged 0–19 years old with FASD with or without ADHD and 170 patients with ADHD without FASD aged 0–19 years old. We train 6 machine learning models based on 13 selected variables and evaluate their performance.

Evaluation of Birth Weight and Neurodevelopmental Conditions Among Monozygotic and Dizygotic Twins.
Johan Isaksson et al. JAMA Netw Open 2023 6 (6) e2321165 (Posted: Jul 01, 2023 9AM)

After adjustment for genetic factors, is birth weight associated with neurodevelopmental conditions? In this case-control study of 393 twins in Sweden, the twin with a lower birth weight in monozygotic twin pairs, but not dizygotic pairs, had more autism and attention-deficit/hyperactivity disorder (ADHD) symptoms, lower IQ ratings, and higher odds of having a diagnosis of autism and ADHD compared with their co-twin. These findings suggest that birth weight contributes to neurodevelopmental conditions when adjusting for genetic factors.

Association between Gut Microbiota and Emotional-Behavioral Symptoms in Children with Attention-Deficit/Hyperactivity Disorder
MJ Lee et al, J Per Medicine, September 29, 2022 (Posted: Oct 02, 2022 9AM)

Previous studies have explored the role of the microbiome in attention-deficit/hyperactivity disorder (ADHD). However, whether the microbiome is correlated with emotional–behavioral disturbances, the most common comorbid symptom of ADHD, remains unclear. We established a cross-sectional study in which 6- to 18-year-old children with ADHD who were receiving no medication and a healthy control group of children without ADHD were recruited to analyze their microbiome composition.

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups.
Mattheisen Manuel et al. Nature genetics 2022 9 (Posted: Sep 28, 2022 7AM)

Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable neurodevelopmental conditions, with considerable overlap in their genetic etiology. We dissected their shared and distinct genetic etiology by cross-disorder analyses of large datasets. We identified seven loci shared by the disorders and five loci differentiating them. All five differentiating loci showed opposite allelic directions in the two disorders and significant associations with other traits.

Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder.
Rajagopal Veera M et al. Nature genetics 2022 8 (Posted: Aug 05, 2022 8AM)

We evaluated genetic differences among childhood (n?=?14,878), persistent (n?=?1,473) and late-diagnosed (n?=?6,961) ADHD cases alongside 38,303 controls, and rare variant differences in 7,650 ADHD cases and 8,649 controls. We identified four genome-wide significant loci for childhood ADHD and one for late-diagnosed ADHD. We found increased polygenic scores for ADHD in persistent ADHD compared with the other two groups. Childhood ADHD had higher genetic overlap with hyperactivity and autism compared with late-diagnosed ADHD.

Mendelian randomization analysis for attention deficit/hyperactivity disorder: studying a broad range of exposures and outcomes.
Soler Artigas María et al. International journal of epidemiology 2022 6 (Posted: Jun 18, 2022 10AM)

We used genome-wide association study (GWAS) summary statistics for ADHD (n?=?53?293) and 124 traits related to anthropometry, cognitive function and intelligence, early life exposures, education and employment, lifestyle and environment, longevity, neurological, and psychiatric and mental health or personality and psychosocial factors available in the MR-Base database (16?067 =n?=766?345). Our findings strengthen previous evidence of a causal effect of ADHD liability on smoking and major depression, and are consistent with a causal effect on odds of decreased average total household income [odds ratio (OR)?=?0.966, 95% credible interval (CrI)?=?(0.954, 0.979)] and increased lifetime number of sexual partners [OR?=?1.023, 95% CrI?=?(1.013, 1.033)].

Why Family Health History is Important if You or Your Child has Learning or Attention Problems
CDC, June 13, 2022 (Posted: Jun 13, 2022 3PM)

Difficulties with learning and attention can run in families. Knowing about this family health history can help your child’s health care provider make a diagnosis if your child is having difficulty with learning or attention. Having a family member, especially another child, with a learning or attention problem can help you identify concerns early in your child. Finding learning and attention disorders early can help your child get services sooner, which can help your child succeed. Finding out more about family health history can help some parents discover for the first time that they also have a learning disorder or ADHD that has not been diagnosed or treated. However, having family members with learning or attention disorders does not automatically mean that your child will have a problem with learning or attention.

Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide
YY Joo et al, JAMA Network Open, February 21, 2022 (Posted: Feb 22, 2022 8AM)

Are genome-wide polygenic scores for specific psychiatric and common traits associated with high risk of suicide among preadolescent youths? In this cohort study of 11?869 preadolescent youths in the US, multiple genome-wide polygenic scores were significantly associated with suicidal thoughts and behaviors (ideation or attempts); specific genome-wide polygenic scores associated with the risk of suicide included attention-deficit/hyperactivity disorder, general happiness, and posttraumatic stress disorder.

Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD
SH Collins et al, NPJ Digital Medicine, March 26, 2021 (Posted: Mar 27, 2021 6AM)

Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
CA Moreau et al, Nature Comms, October 19, 2020 (Posted: Oct 20, 2020 7AM)

16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging data from 101 CNV carriers, 755 individuals with idiopathic ASD, SZ, or ADHD and 1,072 controls.

Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study
KX Lim et al, PLOS Medicine, June 1, 2020 (Posted: Jun 03, 2020 7AM)

We used data from UK Biobank participants to investigate 24 potential individual risk factors for self-harm.Out of these 24 risk factors, major depressive disorder, attention-deficit hyperactivity disorder and schizophrenia appeared to be the most plausible causal risk factors for self-harm.?

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD
D Demontis et al, BioRXIV Genomics, October 2019 (Posted: Oct 22, 2019 9AM)

Here we report a large genome wide association meta-analysis of ADHD based on seven cohorts in total including 3,802 cases and 31,305 controls. Three genome-wide significant loci were identified on chromosomes 1, 7, and 11.

A large data resource of genomic copy number variation across neurodevelopmental disorders
Mehdi Zarrei, et al. Genomic Medcine, October 7, 2019 (Posted: Oct 10, 2019 8AM)

Multiple studies have attempted to identify shared etiology among NDDs, but this is the first genome-wide CNV analysis across autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), and obsessive-compulsive disorder (OCD) at once. The study found clinically relevant CNVs (broadly defined) in 284 (10.5%) of total subjects.

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome
Z Yang et al, BioRXIV, September 16, 2019 (Posted: Sep 17, 2019 7AM)

New Opportunities With School-Based Telehealth: Convenient Connections to Care.
Frey Sean M et al. JAMA pediatrics 2019 Sep (Posted: Sep 10, 2019 9AM)

Future studies should test whether telemedicine can similarly improve the delivery of guideline-based preventive care for children with asthma and other chronic conditions, including attention deficit/hyperactivity disorder and diabetes. All children may not benefit equally from school-based telemedicine.

Association of Genetic and Environmental Risks for Attention-Deficit/Hyperactivity Disorder With Hypomanic Symptoms in Youths.
Hosang Georgina M et al. JAMA psychiatry 2019 Aug (Posted: Aug 15, 2019 8AM)

More than a quarter of the genetic risk factors for adolescent hypomanic traits were also associated with ADHD symptoms in childhood and adolescence, with hypomania-specific genetic risk factors detected. This study suggests that ADHD and hypomanic symptoms are associated with shared genetic factors, which should be the focus of further research.

Examining the Importance of Family History in Pediatric Behavioural Referrals.
Gander Sarah et al. Cureus 2019 May 11(5) e4790 (Posted: Aug 14, 2019 8AM)

Sibling Recurrence Risk and Cross-aggregation of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder
M Miller et al, JAMA Pediatrics, December 10, 2018 (Posted: Dec 10, 2018 11AM)

A vast study seeks to understand the genetic underpinnings of ADHD
The Economist, November 2018 (Posted: Dec 03, 2018 1PM)

Do borderline personality disorder and attention-deficit/hyperactivity disorder co-aggregate in families? A population-based study of 2 million Swedes.
Kuja-Halkola Ralf et al. Molecular psychiatry 2018 Oct (Posted: Nov 27, 2018 10AM)

Familial association of attention-deficit hyperactivity disorder with autoimmune diseases in the population of Sweden.
Li Xinjun et al. Psychiatric genetics 2018 Nov (Posted: Nov 27, 2018 10AM)

Genetic testing in children and adolescents with intellectual disability.
Bass Nick et al. Current opinion in psychiatry 2018 Nov (6) 490-495 (Posted: Nov 27, 2018 10AM)

Twenty years of research on attention-deficit/hyperactivity disorder (ADHD): looking back, looking forward.
Cortese Samuele et al. Evidence-based mental health 2018 Nov (4) 173-176 (Posted: Nov 27, 2018 10AM)

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
D Demontis et al, Nat Genetics, November 26, 2018 (Posted: Nov 27, 2018 10AM)

Genetics of Attention-Deficit/Hyperactivity Disorder: an update.
Akutagava-Martins Glaucia Chiyoko et al. Expert review of neurotherapeutics 2015 Dec (Posted: Jan 05, 2016 0PM)

Childhood attention-deficit/hyperactivity disorder symptoms and the development of adolescent alcohol problems: A prospective, population-based study of Swedish twins.
Quinn Patrick D et al. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015 Dec (Posted: Jan 05, 2016 0PM)

Rethinking Attention-Deficit/Hyperactivity Disorder
DA Christakis, JAMA Pediatrics, January 4, 2016 (Posted: Jan 05, 2016 0PM)

A Population-Based Imaging Genetics Study of Inattention/Hyperactivity: Basal Ganglia and Genetic Pathways.
Mous Sabine E et al. Journal of the American Academy of Child and Adolescent Psychiatry 2015 Sep (9) 745-52 (Posted: Oct 13, 2015 1PM)

Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population.
Pettersson E et al. Molecular psychiatry 2015 Aug (Posted: Oct 13, 2015 1PM)

Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD.
van Goozen Stephanie H M et al. Journal of child psychology and psychiatry, and allied disciplines 2015 Sep (Posted: Oct 13, 2015 1PM)

The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome.
Niarchou Maria et al. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015 Sep (Posted: Oct 13, 2015 1PM)

Attention Deficit Hyperactivity Disorder in the Light of the Epigenetic Paradigm.
Schuch Viviane et al. Frontiers in psychiatry 2015 126 (Posted: Oct 13, 2015 1PM)

Behavior Therapy First for Young Children with ADHD
Brand (Posted: Oct 13, 2015 1PM)

Genetic and Environmental Influences on the Developmental Course of Attention-Deficit/Hyperactivity Disorder Symptoms From Childhood to Adolescence.
Pingault Jean-Baptiste et al. JAMA Psychiatry 2015 Jul 1. (7) 651-8 (Posted: Aug 10, 2015 9AM)

LPHN3 and attention-deficit/hyperactivity disorder: a susceptibility and pharmacogenetic study.
Bruxel E M et al. Genes Brain Behav. 2015 Jun (5) 419-27 (Posted: Aug 10, 2015 9AM)

The Genetic Overlap of Attention-Deficit/Hyperactivity Disorder and Autistic-like Traits: an Investigation of Individual Symptom Scales and Cognitive markers.
Pinto Rebecca et al. J Abnorm Child Psychol 2015 May 30. (Posted: Aug 10, 2015 9AM)

Converging evidence does not support GIT1 as an ADHD risk gene.
Klein Marieke et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2015 Jun 10. (Posted: Aug 10, 2015 9AM)

New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder.
Alemany Silvia et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2015 Jul 14. (Posted: Aug 10, 2015 9AM)

Attention-deficit/hyperactivity disorder
Stephen V. Faraone et al. Nature Reviews Disease Primers, August 2015 (Posted: Aug 10, 2015 9AM)

Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children.
Groen-Blokhuis Maria M et al. J Am Acad Child Adolesc Psychiatry 2014 Oct (10) 1123-9.e6 (Posted: Apr 02, 2015 1PM)

Case-control genome-wide association study of persistent attention-deficit hyperactivity disorder identifies FBXO33 as a novel susceptibility gene for the disorder.
Sánchez-Mora Cristina et al. Neuropsychopharmacology 2015 Mar (4) 915-26 (Posted: Apr 02, 2015 1PM)

Copy number variants in attention-deficit hyperactive disorder: identification of the 15q13 deletion and its functional role.
Valbonesi Stefano et al. Psychiatr. Genet. 2015 Apr (2) 59-70 (Posted: Apr 02, 2015 1PM)

Annual Research Review: Rare genotypes and childhood psychopathology - uncovering diverse developmental mechanisms of ADHD risk.
Scerif Gaia et al. J Child Psychol Psychiatry 2015 Mar (3) 251-73 (Posted: Apr 02, 2015 1PM)

The molecular genetic architecture of attention deficit hyperactivity disorder.
Hawi Z et al. Mol. Psychiatry 2015 Mar (3) 289-97 (Posted: Apr 02, 2015 1PM)

The relative contribution of common and rare genetic variants to ADHD.
Martin J et al. Transl Psychiatry 2015 e506 (Posted: Apr 02, 2015 1PM)

Cadherin-13 gene is associated with hyperactive/impulsive symptoms in attention/deficit hyperactivity disorder.
Salatino-Oliveira Angélica et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2015 Apr (3) 162-9 (Posted: Apr 02, 2015 1PM)

Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD.
Stergiakouli Evie et al. J Am Acad Child Adolesc Psychiatry 2015 Apr (4) 322-7 (Posted: Apr 02, 2015 1PM)

CDC Information: ADHD Treatment Data
Learn about the patterns of treatment of ADHD, and what more could be done to improve the quality of care for children with ADHD. Brand (Posted: Feb 25, 2015 0PM)

Attention-Deficit / Hyperactivity Disorder (ADHD)
Brand (Posted: Feb 25, 2015 0PM)

Key Findings: Trends in the Parent-Report of Health Care Provider-Diagnosis and Medication Treatment for ADHD: United States, 2003—2011
Brand (Posted: Feb 25, 2015 0PM)

FastStats on ADHD
Brand (Posted: Feb 25, 2015 0PM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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