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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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111 hot topic(s) found with the query "Antimicrobial resistance"

A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial.
Rainer Tan et al. Nat Med 2023 12 (Posted: Dec 22, 2023 10AM)

From the abstract: "Excessive antibiotic use and antimicrobial resistance are major global public health threats. We developed ePOCT+, a digital clinical decision support algorithm in combination with C-reactive protein test, hemoglobin test, pulse oximeter and mentorship, to guide health-care providers in managing acutely sick children under 15?years old. To evaluate the impact of ePOCT+ compared to usual care, we conducted a cluster randomized controlled trial in primary care facilities. The use of ePOCT+ in intervention facilities resulted in a reduction in the coprimary outcome of antibiotic prescription compared to usual care (23.2% versus 70.1%, adjusted difference -46.4%, 95% confidence interval (CI) -57.6 to -35.2). "

Harnessing genomics for antimicrobial resistance surveillance
The Lancet Series, November 2023 (Posted: Nov 17, 2023 8AM)

From the article: "Historically, surveillance of bacteria harboring antimicrobial resistance (AMR) has relied on phenotypic analysis of isolates taken from infected individuals, which provides only a low-resolution view of the epidemiology behind an individual infection or wider outbreak. Recent years have seen increasing adoption of powerful new genomic technologies with the potential to revolutionize AMR surveillance by providing a high-resolution picture of the AMR profile of the bacteria causing infections and providing real-time actionable information for treating and preventing infection. "

Global trends in the increasing prevalence of the fosfomycin resistance genenin Staphylococcus aureus
DFM Monte et al, Lancet Microbe, November 2023 (Posted: Nov 11, 2023 3PM)

From the paper: " Our results revealed that 59?065 (55·7%) of 106?005 S aureus strains harboured the fosB gene. Our comprehensive genomic analysis of the global distribution of S aureus strains carrying fosfomycin resistance genes revealed their presence in 34 countries. This prevalence extends to several continents, highlighting the widespread nature of this resistance mechanism."

Genomic surveillance for antimicrobial resistance - a One Health perspective.
Steven P Djordjevic et al. Nat Rev Genet 2023 9 (Posted: Sep 29, 2023 7AM)

From the abstract: "To understand and manage the threat posed to health (human, animal, plant and environmental) and security (food and water security and biosecurity), a multifaceted ‘One Health’ approach to AMR surveillance is required. Genomic technologies have enabled monitoring of the mobilization, persistence and abundance of AMR genes and mutations within and between microbial populations. Their adoption has also allowed source-tracing of AMR pathogens and modelling of AMR evolution and transmission. "

How to fight antibiotic resistance.
Mike May et al. Nat Med 2023 7 (7) 1583-1586 (Posted: Jul 19, 2023 7AM)

Researchers use artificial intelligence and bioinformatics to discover new antimicrobials, while governments pilot financial incentives for pharma. Antimicrobial resistance (AMR) to existing medicines creates one of the biggest dangers for global health. According to the Antimicrobial Resistance Collaborators, AMR had a role in 4.95 million deaths in 2019, with the highest death rate — 27.3 deaths per 100,000 people — found in sub-Saharan Africa. This is a problem that only promises to get worse.

The evolution and international spread of extensively drug resistant Shigella sonnei.
Lewis C E Mason et al. Nature communications 2023 4 (1) 1983 (Posted: Apr 10, 2023 7AM)

Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a most recent common ancestor in 2018 carrying a low-fitness cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data.

An ISO-certified genomics workflow for identification and surveillance of antimicrobial resistance
NL Sherry et al, Nature Comm, January 4, 2023 (Posted: Jan 05, 2023 5AM)

Here, we report the creation and validation of abritAMR, an ISO-certified bioinformatics platform for genomics-based bacterial AMR gene detection. The abritAMR platform utilises NCBI’s AMRFinderPlus, as well as additional features that classify AMR determinants into antibiotic classes and provide customised reports. We validate abritAMR by comparing with PCR or reference genomes, representing 1500 different bacteria and 415 resistance alleles.

Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections
PH Serpa et al, Genome Medicine, July 12, 2022 (Posted: Jul 12, 2022 1PM)

Antimicrobial resistance (AMR) is rising at an alarming rate and complicating the management of infectious diseases including lower respiratory tract infections (LRTI). Metagenomic next-generation sequencing (mNGS) is a recently established method for culture-independent LRTI diagnosis, but its utility for predicting AMR has remained unclear. We aimed to assess the performance of mNGS for AMR prediction in bacterial LRTI and demonstrate proof of concept for epidemiological AMR surveillance and rapid AMR gene detection using Cas9 enrichment and nanopore sequencing.

Tracing the origins of antibiotic resistance
CMJE vandenbrook et al, Nature Medicine, March 22, 2022 (Posted: Mar 26, 2022 3PM)

It has long been known that resistance exists to every single type of antibiotic in clinical use, without exception, though the origins and mechanisms of this resistance have long remained elusive. It was thought that the development of resistance was driven by the use of antibiotics in the clinic and in farming. We now understand that, as most antibiotic compounds are derived from nature, resistance is the result of ongoing evolution and that there is a constant flow of resistance genes between different ecological niches — not only human and animal, but also environmental.

Exploiting genomics to mitigate the public health impact of antimicrobial resistance
C Waddington et al, Genome Medicine, February 16, 2022 (Posted: Feb 17, 2022 10AM)

This review explores how WGS techniques have advanced global, national, and local AMR surveillance, and how this improved understanding is being applied to inform solutions, such as novel diagnostic methods that allow antimicrobial use to be optimized and vaccination strategies for better controlling AMR. We highlight some future opportunities for AMR control informed by genomic sequencing, along with the remaining challenges that must be overcome to fully realise the potential of WGS approaches for international AMR control.

Whole genome sequencing-based classification of human-related Haemophilus species and detection of antimicrobial resistance genes
M Diricks et al, Genome Medicine, February 9, 2022 (Posted: Feb 10, 2022 8AM)

A gene presence/absence-based classification algorithm was developed, which employs the open-source gene-detection tool SRST2 and a new classification database comprising 36 genes, including capsule loci for serotyping. The newly developed algorithm can differentiate between clinically relevant Haemophilus species including, but not limited to, H. influenzae, H. haemolyticus, and H. parainfluenzae.

Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning
C Weiss et al, Nature Medicine, January 10, 2022 (Posted: Jan 11, 2022 8AM)

This dataset combines more than 300,000 mass spectra with more than 750,000 antimicrobial resistance phenotypes from four medical institutions. Validation on a panel of clinically important pathogens, including Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae, resulting in areas under the receiver operating characteristic curve of 0.80, 0.74 and 0.74, respectively, demonstrated the potential of using machine learning to substantially accelerate antimicrobial resistance determination and change of clinical management.

Innovative tools take aim at antibiotic-resistant microbes
J Madhusoodanan, Nature, August 23, 2021 (Posted: Aug 24, 2021 8AM)

Researchers are turning to tools such as atomic force microscopy, genomics and machine learning to create point-of-care diagnostic tests that they hope will provide results in minutes, minimizing the use of incorrect or unnecessary prescriptions. “An increase in rapidity is the most important advance needed.”

Vaccinology in the post−COVID-19 era
R Rappuoli et al, PNAS< January 11, 2021 (Posted: Jan 12, 2021 11AM)

Some of the vaccine technologies that are fast-tracked by the urgency of COVID-19 may also be the answer for other health priorities, such as antimicrobial resistance, chronic infections, and cancer, that the post-COVID-19 world will urgently need to face. This perspective analyzes the way COVID-19 is transforming vaccinology and the opportunities for vaccines to have an increasingly important role in health and well-being.

A decision algorithm to promote outpatient antimicrobial stewardship for uncomplicated urinary tract infection
S Kanjilal et al, Science Trans Med, November 4, 2020 (Posted: Nov 05, 2020 6AM)

A machine learning approach was calibrated to local hospital electronic health record data to predict the probability of resistance to antibiotic therapies for uncomplicated UTI. The algorithm then recommended the least broad-spectrum antibiotic to which a given isolate was predicted nonresistant. Use of the pipeline reduced both broad-spectrum and ineffective antibiotic prescription for UTI in the patient cohort relative to clinicians.

Emerging Drug-Resistant Meningitis Detected in the US
BM Kuehn, JAMA, August 11, 2020 (Posted: Aug 13, 2020 10AM)

Uncovering hidden antimicrobial resistance patterns within the hospital microbiome
BW Haak et al, Nature Medicine, June 8, 2020 (Posted: Jun 09, 2020 11AM)

Combined culture-dependent and culture-independent metagenomic sequencing methods reveal the pervasive and long-lasting presence of antimicrobial resistance genes within a tertiary hospital environment.

Editorial: Pathogen Genomics: Empowering Infectious Disease Surveillance and Outbreak Investigations
MJ Struenlens et al, Front Public Health, May 19, 2020 (Posted: May 20, 2020 8AM)

Comparative microbial genomics analysis by high-throughput whole-genome sequencing (WGS) offers exquisite resolution for epidemiological investigations of infectious disease. This approach has revolutionized outbreak detection and monitoring of transmission dynamics of infectious agents and antimicrobial resistance across humans, animals, and environment.

Powerful antibiotics discovered using AI- Machine learning spots molecules that work even against ‘untreatable’ strains of bacteria.
J Marchant, Nature, February 20, 2020 (Posted: Feb 21, 2020 9AM)

A pioneering machine-learning approach has identified powerful new types of antibiotic from a pool of more than 100 million molecules — including one that works against a wide range of bacteria, including tuberculosis and strains considered untreatable.

Notes from the Field: Carbapenem-resistant Klebsiella pneumoniae with mcr-1 Gene Identified in a Hospitalized Patient — Wyoming, January 2019
H Rhoades et al, MMWR, February 14, 2020 (Posted: Feb 18, 2020 9AM)

First identified in the United States in Pennsylvania in 2016 and since then reported in 20 more states, this is the first mcr-1 isolate reported in Wyoming or surrounding states. The patient’s frequent intermittent antibiotic use could have increased the risk for contracting antibiotic-resistant bacteria, but the route of acquisition is unknown

One year cross-sectional study in adult and neonatal intensive care units reveals the bacterial and antimicrobial resistance genes profiles in patients and hospital surfaces
AP Christoff et al, MedRXIV, February 13, 2020 (Posted: Feb 15, 2020 9AM)

Innovative and rapid antimicrobial susceptibility testing systems
AV Belkum et al, Nature Rev Microbiology, February 2020 (Posted: Feb 14, 2020 8AM)

Over the past 30 years, only a few high-throughput AST methods have been developed and widely implemented. By contrast, several studies have established proof of principle for various innovative AST methods, including both molecular-based and genome-based methods, which await clinical trials and regulatory review.

U.S. continues to lead the fight against antibiotic resistance
A Azar et al, Stat News, December 4, 2019 (Posted: Dec 04, 2019 0PM)

By coupling innovation with a now-proven strategy of commonsense interventions, we can win real victories. And by maintaining vigilance, spurring innovation, and sustaining global partnerships, we are protecting lives and the promise of modern medicine for generations to come

Biggest Threats and Data- 2019 AR Threats Report
CDC, November 2019 Brand (Posted: Nov 15, 2019 7AM)

More than 2.8 million antibiotic-resistant infections occur in the U.S. each year, and more than 35,000 people die as a result. In addition, 223,900 cases of Clostridioides difficile occurred in 2017 and at least 12,800 people died.

Machine learning based prediction of antibiotic sensitivity in patients with critical illness
D Ghosh et al, MedRXIV, September 20, 2019 (Posted: Sep 20, 2019 9AM)

Pathogen Genomics: Empowering Infectious Disease Surveillance and Outbreak Investigations
Frontiers Research Topic, 2019 (Posted: Aug 28, 2019 7AM)

With progress in high throughput nucleic acid sequencing technology, comparative microbial genomics is increasingly used for high resolution epidemiological investigation of sources and transmission dynamics of infectious agents and antimicrobial resistance determinants in humans, animals, and environmental reservoirs.

Public Health and Epidemiology Informatics: Can Artificial Intelligence Help Future Global Challenges? An Overview of Antimicrobial Resistance and Impact of Climate Change in Disease Epidemiology.
Rodríguez-González Alejandro et al. Yearbook of medical informatics 2019 Aug 28(1) 224-231 (Posted: Aug 21, 2019 9AM)

Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London
R Cave et al, Scientific Reports, August 1, 2019 (Posted: Aug 02, 2019 8AM)

This study compared staphylococci isolates recovered from high frequency touched surfaces from public areas in the community and hospitals in East and West London. 281 out of 600 (46.83%) staphylococci isolates recovered were multidrug resistant.

Genomic epidemiology of syphilis reveals independent emergence of macrolide resistance across multiple circulating lineages
MA Beale et al, Nature Communications, July 22, 2019 (Posted: Jul 23, 2019 8AM)

The study used direct sequencing of T. pallidum combined with phylogenomic analyses to inform our understanding of the current syphilis epidemic by demonstrating how macrolide resistance evolves in Treponema subspecies and provide a warning on broader issues of antimicrobial resistance.

Personal clinical history predicts antibiotic resistance of urinary tract infections
I Yelin et al, Nature Medicine, July 4, 2019 (Posted: Jul 05, 2019 8AM)

Machine-learning-assisted selection of antibiotic prescription
X Didelot et al, Nature Medicine, July 4, 2019 (Posted: Jul 05, 2019 8AM)

Machine learning can use patients? demographic information and previous clinical history to help physicians select the antibiotics most likely to successfully treat urinary tract infections, despite growing levels of resistance.

Sequencing-based methods and resources to study antimicrobial resistance
M Boolchaldani et al, Nature Reviews Genetics, March 18, 2019 (Posted: Mar 19, 2019 7AM)

This chip can quickly identify the microbes living in your body
RF Service, Science, July 16, 2018 (Posted: Jul 17, 2018 10AM)

Multiplexed identification, quantification and genotyping of infectious agents using a semiconductor biochip.
Hassibi Arjang et al. Nature biotechnology 2018 Jul (Posted: Jul 17, 2018 10AM)

Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens
S Baker et al, Science, May 18, 2018 (Posted: May 18, 2018 8AM)

Be Antibiotics Aware: Smart Use, Best Care
CDC Public Health Grand Round, May 15, 2018 (Posted: May 15, 2018 10AM)

Stop Spread of Unusual Antibiotic Resistance
Brand (Posted: Apr 24, 2018 9AM)

Containing Unusual Resistance
CDC Vital Signs, Apr 3, 2018 Brand (Posted: Apr 03, 2018 3PM)

What Everyone Should Know
Brand (Posted: Mar 06, 2018 9AM)

Narrowing the spectrum: the new frontier of precision antimicrobials
AE Paharik et al, Genome Medicine, December 2017 (Posted: Dec 15, 2017 10AM)

Comparison of phenotypic and WGS-derived antimicrobial resistance profiles of Salmonella enterica serovars Typhi and Paratyphi.
Day Martin R et al. The Journal of antimicrobial chemotherapy 2017 Dec (Posted: Dec 08, 2017 10AM)

Action and resistance mechanisms of antibiotics: A guide for clinicians.
Kapoor Garima et al. Journal of anaesthesiology, clinical pharmacology (3) 300-305 (Posted: Nov 13, 2017 11AM)

Phage Therapy’s Role in Combating Antibiotic-Resistant Pathogens
J Lyon, JAMA, Oct 25, 2017 (Posted: Oct 25, 2017 11AM)

Understanding and overcoming antibiotic resistance.
Richardson Lauren A et al. PLoS biology 2017 Aug (8) e2003775 (Posted: Aug 31, 2017 7AM)

Antimicrobial resistance: The complex challenge of measurement to inform policy and the public.
Wernli Didier et al. PLoS medicine 2017 Aug (8) e1002378 (Posted: Aug 31, 2017 7AM)

Next-generation sequencing to monitor the spread of antimicrobial resistance
M Otto, Genome Medicine, July 2017 (Posted: Aug 02, 2017 0PM)

National Strategy to Combat Antibiotic-Resistant Bacteria
(Posted: Jul 30, 2017 8PM)

Genomic sequencing of Neisseria gonorrhoeae to respond to the urgent threat of antimicrobial-resistant gonorrhea
Brand (Posted: Jul 30, 2017 8PM)

Antibiotic Resistance, Food, and Food-Producing Animals
Brand (Posted: Jul 30, 2017 11AM)

Next-generation approaches to understand and combat the antibiotic resistome.
Crofts Terence S et al. Nature reviews. Microbiology 2017 Jul (7) 422-434 (Posted: Jul 28, 2017 9AM)

Antibiotic Use in the United States, 2017: Progress and Opportunities
Brand (Posted: Jul 28, 2017 9AM)

Resistance to last-ditch antibiotic has spread farther than anticipated
S Reardon, Nature News, June 12, 2017 (Posted: Jun 13, 2017 8AM)

Infectious Fight: Tackling the Inevitability of Resistance, One Genome at a Time
Clinical Omics, February 7, 2017 (Posted: Feb 08, 2017 8AM)

The Microbiome & Innovations to Slow Antibiotic Resistance
Brand (Posted: Jan 12, 2017 0PM)

CDC's strategic investments empower the nation to combat antibiotic resistance
Brand (Posted: Jan 12, 2017 0PM)

CDC AR Solutions Initiative Fact Sheets by Topic
Brand (Posted: Jan 12, 2017 0PM)

The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report of EUROCAST committee
(Posted: Dec 23, 2016 6AM)

Scientists seek a way to predict antibiotic resistance
S Love, Stat News, November 7, 2016 (Posted: Nov 07, 2016 8AM)

Strain Dependent Genetic Networks for Antibiotic-Sensitivity in a Bacterial Pathogen with a Large Pan-Genome.
van Opijnen Tim et al. PLoS pathogens 2016 Sep (9) e1005869 (Posted: Nov 07, 2016 8AM)

Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes.
Adu-Oppong Boahemaa et al. Annals of the New York Academy of Sciences 2016 Oct (Posted: Nov 02, 2016 6AM)

Functional Metagenomics as a Tool for Identification of New Antibiotic Resistance Genes from Natural Environments.
Dos Santos Débora Farage Knupp et al. Microbial ecology 2016 Oct (Posted: Oct 07, 2016 8AM)

Antimicrobial Resistance
HD Marston et al, JAMA, September 20, 2016 (Posted: Sep 20, 2016 7PM)

Antibiotic Resistant Bacteria and the World's Peril
L Garret, Scientific American Blog, Sept 19, 2016 (Posted: Sep 20, 2016 7AM)

Investigation of Escherichia coli Harboring the mcr-1 Resistance Gene — Connecticut, 2016
MMWR, September 9, 2016 (Posted: Sep 09, 2016 5PM)

Tracking mcr -1
(Posted: Sep 09, 2016 5PM)

Investigation of First Identified mcr-1 Gene in an Isolate from a U.S. Patient — Pennsylvania, 2016
MMWR, September 9, 2016 (Posted: Sep 09, 2016 5PM)

Finding risks in a flood of genetic data: Sequencing improvements aid resistance study, outbreak response
G Cima, JAVMA News, July 13, 2016 (Posted: Jul 18, 2016 7PM)

Neisseria gonorrhoeae Antimicrobial Susceptibility Surveillance — The Gonococcal Isolate Surveillance Project, 27 Sites, United States, 2014
CDC MMWR, July 15, 2016 (Posted: Jul 15, 2016 2PM)

Prevention Epicenters Program supports research on new ways to prevent superbugs and improve healthcare quality
Brand (Posted: Jul 01, 2016 10AM)

FDA clears first test to detect specific genetic markers for certain antibiotic-resistant bacteria directly from clinical specimens
FDA, June 29, 2016 (Posted: Jun 29, 2016 8PM)

Nature Web Collection on Antimicrobial Resistance
June 2016 (Posted: Jun 17, 2016 11AM)

Infection Raises Specter of Superbugs Resistant to All Antibiotics
New York Times, May 2016 (Posted: May 31, 2016 8AM)

AMD Projects: Combating Healthcare-associated Infections
Brand (Posted: Mar 25, 2016 1PM)

Making Health Care Safer: Protect patients from antibiotic resistance
Brand (Posted: Mar 03, 2016 1PM)

Antimicrobial Resistance Genes and Modeling of Treatment Failure in Bacterial Vaginosis: Clinical Study of 289 Symptomatic Women.
Bostwick David G et al. Journal of medical microbiology 2016 Feb (Posted: Mar 01, 2016 8AM)

Why is antibiotic resistance a deadly emerging disease?
Courvalin Patrice et al. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2016 Jan (Posted: Mar 01, 2016 8AM)

Leaders Committed to Antibiotic Stewardship
Brand (Posted: Mar 01, 2016 8AM)

Spread of antibiotic-resistance gene does not spell bacterial apocalypse — yet
S Reardon, Nature News, December 21, 2015 (Posted: Dec 21, 2015 2PM)

Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis
P Bradley et al, Nature Communications, December 21, 2015 (Posted: Dec 21, 2015 10AM)

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study
YY Liu et al, Lancet Infectious Diseases, November 18, 2015 (Posted: Nov 19, 2015 0PM)

High-throughput functional screening reveals low frequency of antibiotic resistance genes in DNA recovered from the Upper Mississippi River.
Staley Christopher et al. Journal of water and health 2015 Sep (3) 693-703 (Posted: Nov 16, 2015 3PM)

Resistance gene naming and numbering: is it a new gene or not?
Hall Ruth M et al. The Journal of antimicrobial chemotherapy 2015 Oct (Posted: Nov 16, 2015 3PM)

Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in Feces.
Zaura Egija et al. mBio 2015 (6) (Posted: Nov 16, 2015 3PM)

Antibiotics Aren't Always the Answer
Brand (Posted: Nov 16, 2015 3PM)

Meta-genomic analysis of toilet waste from long distance flights; a step towards global surveillance of infectious diseases and antimicrobial resistance.
Nordahl Petersen Thomas et al. Sci Rep 2015 11444 (Posted: Aug 19, 2015 0PM)

Antibiotic Resistant and Virulence Determinants of Staphylococcus haemolyticus C10A as Revealed by Whole Genome Sequencing.
Chan Kok-Gan et al. J Genomics 2015 72-4 (Posted: Aug 11, 2015 3PM)

Potential of metabolomics to reveal Burkholderia cepacia complex pathogenesis and antibiotic resistance.
Shommu Nusrat S et al. Front Microbiol 2015 668 (Posted: Aug 11, 2015 3PM)

DNA-Microarray-based Genotyping of Clostridium difficile.
Gawlik Darius et al. BMC Microbiol. 2015 158 (Posted: Aug 11, 2015 3PM)

Vancomycin-resistant enterococcal infections: epidemiology, clinical manifestations, and optimal management.
O'Driscoll Tristan et al. Infect Drug Resist 2015 217-30 (Posted: Aug 11, 2015 3PM)

Review of Established and Innovative Detection Methods for Carbapenemase-Producing gram-negative Bacteria.
Osei Sekyere John et al. J. Appl. Microbiol. 2015 Aug 6. (Posted: Aug 11, 2015 3PM)

Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health.
Holt Kathryn E et al. Proc. Natl. Acad. Sci. U.S.A. 2015 Jul 7. (27) E3574-81 (Posted: Jul 29, 2015 3PM)

Novel Programs and Discoveries Aim to Combat Antibiotic Resistance.
Hampton Tracy et al. JAMA 2015 Jun 3. (Posted: Jun 04, 2015 0PM)

Over 150 Animal and Health Stakeholders Join White House Effort to Combat Antibiotic Resistance
White House Fact Sheet, June 2, 2015 (Posted: Jun 02, 2015 0PM)

The human gut resistome.
van Schaik Willem et al. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2015 Jun 5. (1670) (Posted: Jun 02, 2015 9AM)

Targets for Combating the Evolution of Acquired Antibiotic Resistance.
Culyba Matthew J et al. Biochemistry 2015 May 27. (Posted: Jun 02, 2015 9AM)

Rapid antibiotic resistance predictions from genome sequence data for S. aureus and M. tuberculosis.
Phelim Bradley et al. BioRXIV Server, April 26, 2015 (Posted: Apr 30, 2015 8PM)

WHO report finds systems to combat antibiotic resistance lacking
April 29, 2015 (Posted: Apr 29, 2015 9AM)

Obama unveils $1.2B plan to tackle drug-resistant bacteria
By Sarah Ferris, the Hill, March 27, 2015 (Posted: Mar 31, 2015 10AM)

Population structure of Neisseria gonorrhoeae based on whole genome data and its relationship with antibiotic resistance.
Ezewudo Matthew N et al. PeerJ 2015 e806 (Posted: Mar 30, 2015 5PM)

Investigation of a possible outbreak of carbapenem-resistant Acinetobacter baumannii in Odense, Denmark using PFGE, MLST and whole-genome-based SNPs.
Hammerum Anette M et al. J. Antimicrob. Chemother. 2015 Mar 19. (Posted: Mar 30, 2015 5PM)

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Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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