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Public Health Genomics and Precision Health Knowledge Base (v9.0)
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Precision Health Database|Search|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Pharmacogenomics
Last data update: Apr 25, 2024
. (Total: 63675 Documents since 2012)
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Cost-utility analysis and cross-country comparison of pharmacogenomics-guided treatment in colorectal cancer patients participating in the U-PGx PREPARE study.
Vasileios Fragoulakis et al. Pharmacol Res 2023 106949
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UGT1A1 genotype-guided dosing of irinotecan: time to prioritize patient safety.
Sofía Lj Peeters et al. Pharmacogenomics 2023
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Pharmacogenetics testing (DPYD and UGT1A1) for fluoropyrimidine and irinotecan in routine clinical care: Perspectives of medical oncologists and oncology pharmacists.
Sarah Glewis et al. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2023 10781552231167554
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Towards UGT1A1 guided irinotecan dosing
JK Hicks, EJHG, February 7, 2023
Association between ABCG2, ABCB1, ABCC2 efflux transporters SNP's and irinotecan adverse effects in colorectal cancer patients: a real life study.
Barnett-Griness Ofra et al. Clinical pharmacology and therapeutics 2022
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Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan.
Hulshof Emma C et al. European journal of human genetics : EJHG 2022
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Utilization of Drugs with Pharmacogenetic Dosing Recommendations in Switzerland: A Descriptive Study Using the Helsana Database.
Wittwer Nina L et al. Pharmacogenomics and personalized medicine 2022 15967-976
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Dutch pharmacogenetics working group (DPWG) guideline for the gene–drug interaction between UGT1A1 and irinotecan
E Hulshof et al, EJHG, November 28, 2022
Cost-Effectiveness of Pharmacogenomics-Guided Prescribing to Prevent Gene-Drug-Related Deaths: A Decision-Analytic Model.
van der Wouden Cathelijne H et al. Frontiers in pharmacology 2022 13918493
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Implementing Pharmacogenetic Testing in Gastrointestinal Cancers (IMPACT-GI): Study Protocol for a Pragmatic Implementation Trial for Establishing DPYD and UGT1A1 Screening to Guide Chemotherapy Dosing.
Varughese Lisa A et al. Frontiers in oncology 2022 12859846
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Implementing Pre-Therapeutic UGT1A1 Genotyping in Clinical Practice: A Real-Life Study.
Personeni Nicola et al. Journal of personalized medicine 2022 12(2)
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The Value of Pharmacogenetics to Reduce Drug-Related Toxicity in Cancer Patients.
Mhandire Doreen Z et al. Molecular diagnosis & therapy 2022
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Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing.
Reizine Natalie M et al. Cancer 2022
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Preemptive pharmacogenetic testing to guide chemotherapy dosing in patients with gastrointestinal malignancies: a qualitative study of barriers to implementation.
Lau-Min Kelsey S et al. BMC cancer 2022 22(1) 47
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Real-World Evaluation of Universal Germline Screening for Cancer Treatment-Relevant Pharmacogenes.
Hutchcraft Megan L et al. Cancers 2021 13(18)
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Association of emergence of new mutations in circulating tumuor DNA during chemotherapy with clinical outcome in metastatic colorectal cancer.
Jia Ning et al. BMC cancer 2021 21(1) 845
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Feasibility of preemptive pharmacogenetic testing in colorectal cancer patients within a community oncology setting.
Luczak Tiana S et al. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2021 10781552211005529
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UGT1A1 genotype and irinotecan therapy: general review and implementation in routine practice.
Etienne-Grimaldi Marie-Christine et al. Fundamental & clinical pharmacology 2015 29(3) 219-37
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Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial.
Reizine Natalie et al. Therapeutic advances in medical oncology 2020 121758835920974118
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Cetuximab plus irinotecan administered biweekly with reduced infusion time to heavily pretreated patients with metastatic colorectal cancer and related RAS and BRAF mutation status.
Jensen Benny V et al. International journal of cancer 2020 Dec
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Mutations in DNA Repair Genes and Clinical Outcomes of Patients With Metastatic Colorectal Cancer Receiving Oxaliplatin or Irinotecan-containing Regimens.
Marks Eric I et al. American journal of clinical oncology 2020 Dec
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Pre-therapeutic UGT1A1 genotyping to reduce the risk of irinotecan-induced severe toxicity: Ready for prime time.
Hulshof Emma C et al. European journal of cancer (Oxford, England : 1990) 2020 Oct 1419-20
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Prognosis and personalized treatment prediction in TP53-mutant hepatocellular carcinoma: an in silico strategy towards precision oncology.
Yang Chen et al. Briefings in bioinformatics 2020 Aug
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Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance).
Lenz Heinz-Josef et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 37(22) 1876-1885
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Cost-effectiveness analysis of UGT1A1*6/*28 genotyping for preventing FOLFIRI-induced severe neutropenia in Chinese colorectal cancer patients.
Wei XiaoXia et al. Pharmacogenomics 2019 20(4) 241-249
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Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics.
de Man Femke M et al. Clinical pharmacokinetics 2018 57(10) 1229-1254
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Precision treatment in colorectal cancer: Now and the future.
Yau Tung On et al. JGH open : an open access journal of gastroenterology and hepatology 2019 Oct 3(5) 361-369
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Pharmacogenetic clinical randomised phase II trial to evaluate the efficacy and safety of FOLFIRI with high-dose irinotecan (HD-FOLFIRI) in metastatic colorectal cancer patients according to their UGT1A 1 genotype.
Páez David et al. British journal of cancer 2019 120(2) 190-195
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Local Coverage Determination (LCD): Cetuximab (Erbitux) (L33278)
The U.S. Centers for Medicare & Medicaid Services
Pharmacokinetic and Pharmacogenetic Markers of Irinotecan Toxicity.
Hahn Roberta Zilles et al. Current medicinal chemistry 2019 26(12) 2085-2107
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Page last reviewed:
Feb 1, 2024
Page last updated:
Apr 25, 2024
Content source:
Public Health Genomics Branch in the Division of Blood Disorders and Public Health Genomics
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National Center on Birth Defects and Developmental Disabilities
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