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Public Health Genomics and Precision Health Knowledge Base (v9.0)
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Precision Health Database|Search|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
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Last data update: Apr 25, 2024
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The Biological and Clinical Role of the Telomerase Reverse Transcriptase Gene in Glioblastoma: A Potential Therapeutic Target?
Vincenzo Di Nunno et al. Cells 2024 13(1)
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Actionable molecular alterations in newly diagnosed and recurrent IDH1/2 wild-type glioblastoma patients and therapeutic implications: a large mono-institutional experience using extensive next-generation sequencing analysis.
Marta Padovan et al. Eur J Cancer 2023 191112959
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The Glioma-IRE project - Molecular profiling in patients with glioma: steps toward an individualized diagnostic and therapeutic approach.
Veronica Villani et al. Journal of translational medicine 2023 21(1) 215
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Integrated molecular and clinical analysis of BRAF-mutant glioma in adults.
Karisa C Schreck et al. NPJ precision oncology 2023 7(1) 23
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Study protocol of the GLOW study: maximising treatment options for recurrent glioblastoma patients by whole genome sequencing-based diagnostics-a prospective multicenter cohort study.
van Opijnen Mark P et al. BMC medical genomics 2022 15(1) 233
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Inherited genetics of adult diffuse glioma and polygenic risk scores-a review.
Eckel-Passow Jeanette E et al. Neuro-oncology practice 2022 9(4) 259-270
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Clinical Application of Comprehensive Genomic Profiling Tests for Diffuse Gliomas.
Omura Takaki et al. Cancers 2022 14(10)
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Integrated analysis of single-cell RNA-seq dataset and bulk RNA-seq dataset constructs a prognostic model for predicting survival in human glioblastoma.
Lai Wenwen et al. Brain and behavior 2022 e2575
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Genomic Analysis of Tumors from Patients with Glioblastoma with Long-Term Response to Afatinib.
Owen Scott et al. OncoTargets and therapy 2022 15367-380
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Prospective genomically-guided identification of 'early/evolving' and 'undersampled' IDH-wildtype glioblastoma leads to improved clinical outcomes.
Zhang Yalan et al. Neuro-oncology 2022
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Detection of TERT Promoter Mutations as a Prognostic Biomarker in Gliomas: Methodology, Prospects, and Advances.
Hasanau Tsimur et al. Biomedicines 2022 10(3)
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Genome-Wide Analysis for the Regulation of Gene Alternative Splicing by DNA Methylation Level in Glioma and its Prognostic Implications.
Yang Zeyuan et al. Frontiers in genetics 2022 13799913
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Clinical utility of targeted next generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making.
Lim-Fat Mary Jane et al. Neuro-oncology 2021
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Molecular profile to guide personalized medicine in adult patients with primary brain tumors: results from the ProfiLER trial.
Bonneville-Levard Alice et al. Medical oncology (Northwood, London, England) 2021 39(1) 4
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Prognostic implications of epidermal and platelet-derived growth factor receptor alterations in 2 cohorts of IDHwt glioblastoma.
Alnahhas Iyad et al. Neuro-oncology advances 2021 3(1) vdab127
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Combination chemotherapy versus temozolomide for patients with methylated MGMT (m-MGMT) glioblastoma: results of computational biological modeling to predict the magnitude of treatment benefit.
Castro Michael et al. Journal of neuro-oncology 2021
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Differential Predictors and Clinical Implications Associated With Long-Term Survivors in IDH Wildtype and Mutant Glioblastoma.
Jiang Haihui et al. Frontiers in oncology 2021 11632663
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BRAF more frequently co-occurs with IDH1/2 mutations in adult patients with gliomas than in patients harboring BRAF but without a survival advantage.
Wang Wei et al. BMC neurology 2021 21(1) 195
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The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance.
Leelatian Nalin et al. Neurosurgery clinics of North America 2021 32(2) 171-180
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Evaluation of an Assay for MGMT Gene Promoter Methylation in Glioblastoma Samples.
Filipits Martin et al. Anticancer research 2020 Nov 40(11) 6229-6236
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Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma.
Satomi Kaishi et al. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2020 Oct
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Novel Molecular Markers in Glioblastoma-Benefits of Liquid Biopsy.
Birkó Zsuzsanna et al. International journal of molecular sciences 2020 Oct 21(20)
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Incorporating genomic signatures into surgical and medical decision-making for elderly glioblastoma patients.
Ene Chibawanye I et al. Neurosurgical focus 2020 Oct 49(4) E11
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Development of a Nomogram With Alternative Splicing Signatures for Predicting the Prognosis of Glioblastoma: A Study Based on Large-Scale Sequencing Data.
Wang Zihao et al. Frontiers in oncology 2020 101257
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Targeted next-generation sequencing of adult gliomas for retrospective prognostic evaluation and up-front diagnostics.
Petersen Jeanette K et al. Neuropathology and applied neurobiology 2020 Jul
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A Molecular Signature associated with prolonged survival in Glioblastoma patients treated with Regorafenib.
Santangelo Alessandra et al. Neuro-oncology 2020 Jul
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A fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas.
Calabrese Evan et al. Scientific reports 2020 Jul 10(1) 11852
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Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities.
Oh Sejin et al. Nature communications 2020 Jul 11(1) 3288
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Assessment of genetic and non-genetic risk factors for venous thromboembolism in glioblastoma - The predictive significance of B blood group.
Heenkenda Menikae K et al. Thrombosis research 2019 Nov 183136-142
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Integrating Genomic Data with Transcriptomic Data for Improved Survival Prediction for Adult Diffuse Glioma.
Yang Qi et al. Journal of Cancer 2020 11(13) 3794-3802
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Page last reviewed:
Feb 1, 2024
Page last updated:
Apr 25, 2024
Content source:
Public Health Genomics Branch in the Division of Blood Disorders and Public Health Genomics
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National Center on Birth Defects and Developmental Disabilities
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