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Public Health Genomics and Precision Health Knowledge Base (v9.0)
PHGKB
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Public Health Genomics Branch
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Precision Health Database|Search|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Last data update: Apr 30, 2024
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Heritable human genome editing: correction, selection and treatment.
Rosamund Scott et al. Med Law Rev 2024
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How CRISPR gene editing could help treat Alzheimer’s
T Thompson, Nature, December 11, 2023
In historic decision, FDA approves a CRISPR-based medicine for treatment of sickle cell disease
A Feurstein, StatNews, December 8, 2023
CRISPR 2.0: a new wave of gene editors heads for clinical trials Landmark approval of the first CRISPR therapy paves the way for treatments based on more efficient and more precise genome editors.
H Ledford, Nature, December 7, 2023
Genome editing for sickle cell disease: still time to correct?
Giulia Ceglie et al. Front Pediatr 2023 111249275
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A new age of precision gene therapy.
Axel Schambach et al. Lancet 2023
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'Treasure trove' of new CRISPR systems holds promise for genome editing.
Sara Reardon et al. Nature 2023
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UK first to approve CRISPR treatment for diseases: what you need to know
C Wong. Nature. November 16, 2023
First trial of 'base editing' in humans lowers cholesterol - but raises safety concerns.
Miryam Naddaf et al. Nature 2023
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Commoning genomic solidarity to improve global health equality.
Joy Y Zhang et al. Cell Genom 2023 3(10) 100405
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Super-precise CRISPR tool enters US clinical trials for the first time.
Heidi Ledford et al. Nature 2023
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The divide so wide: Public perspectives on the role of human genome editing in the US healthcare system.
John P Nelson et al. Public Underst Sci 2023 9636625231189955
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Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions.
Karla Alex et al. J Med Ethics 2023
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Evolved Eugenics and Reinforcement of "Othering": Renewed Ethico-Legal Perspectives of Genome Editing in Reproduction.
Pin Lean Lau et al. BioTech (Basel) 2023 12(3)
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Towards an appropriate African framework for public engagement with human genome editing: a call to synergistic action.
Gerald Michael Ssebunnya et al. Wellcome Open Res 2023 7302
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Development of orphan drugs for rare disease.
Han-Wook Yoo et al. Clin Exp Pediatr 2023
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Genome Editing for Cystic Fibrosis.
Guoshun Wang et al. Cells 2023 12(12)
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Potent and uniform fetal hemoglobin induction via base editing.
Thiyagaraj Mayuranathan et al. Nat Genet 2023
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Unleashing CRISPR on Cancer.
et al. N Engl J Med 2023 388(25) e78
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"What if" should precede "whether" and "how" in the social conversation around human germline gene editing.
Diewertje Houtman et al. J Community Genet 2023
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CRISPR Therapy Exceeds Targets in Thalassemia, Sickle Cell Disease
M Basset, Medpage today, June 13, 2023
Duchenne Muscular Dystrophy Gene Therapy in 2023: Status, Perspective, and Beyond.
Dongsheng Duan et al. Hum Gene Ther 2023 34(9-10) 345-349
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CRISPR Editing Takes Aim at Ischemia/Reperfusion Injury.
Oscar E Reyes Gaido et al. JAMA Cardiol 2023
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Acceptance of genetic editing and of whole genome sequencing of human embryos by patients with infertility before and after the onset of the COVID-19 pandemic.
Werner M Neuhausser et al. Reprod Biomed Online 2023
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Human embryo science: can the world’s regulators keep pace? Concerned by the speed of research, policymakers are looking for alternative ways to establish rules on genome editing and other technologies.
P Ball, Nature, May 10, 2023
The ethics, equity, and governance of human genome editing need greater consideration.
Sarojini Nadimpally et al. BMJ 2023 381p996
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Mapping the 'Ethical' Controversy of Human Heritable Genome Editing: a Multidisciplinary Approach.
Richard Pougnet et al. Asian Bioeth Rev 2023 15(2) 189-204
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Novel and future lipid-modulating therapies for the prevention of cardiovascular disease.
Julia Brandts et al. Nat Rev Cardiol 2023
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Food and Drug Administration Guidance on Design of Clinical Trials for Gene Therapy Products with Potential for Genome Integration or Genome Editing and Associated Long-Term Follow-Up of Research Subjects.
Daniel Eisenman et al. Applied biosafety : journal of the American Biological Safety Association 2023 27(4) 201-209
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In the business of base editors: Evolution from bench to bedside.
Elizabeth M Porto et al. PLoS Biol 2023 21(4) e3002071
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Page last reviewed:
Feb 1, 2024
Page last updated:
Apr 30, 2024
Content source:
Public Health Genomics Branch in the Division of Blood Disorders and Public Health Genomics
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National Center on Birth Defects and Developmental Disabilities
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