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Public Health Genomics and Precision Health Knowledge Base (v9.0)
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Precision Health Database|Search|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Pharmacogenomics
Last data update: Apr 25, 2024
. (Total: 63675 Documents since 2012)
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Cost-utility analysis and cross-country comparison of pharmacogenomics-guided treatment in colorectal cancer patients participating in the U-PGx PREPARE study.
Vasileios Fragoulakis et al. Pharmacol Res 2023 106949
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Addressing barriers to increased adoption of DPYD genotyping at a large multisite cancer center.
Sarah A Morris et al. Am J Health Syst Pharm 2023
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Cost-Effectiveness Analysis of a New Second-Line Treatment Regimen for Advanced Intrahepatic Cholangiocarcinoma: Biomarker-Driven Targeted Therapy of Pemigatinib Versus 5-FU Chemotherapy.
Chueh Chen-Han et al. PharmacoEconomics 2022
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Utilization of Drugs with Pharmacogenetic Dosing Recommendations in Switzerland: A Descriptive Study Using the Helsana Database.
Wittwer Nina L et al. Pharmacogenomics and personalized medicine 2022 15967-976
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Cost-Effectiveness of Pharmacogenomics-Guided Prescribing to Prevent Gene-Drug-Related Deaths: A Decision-Analytic Model.
van der Wouden Cathelijne H et al. Frontiers in pharmacology 2022 13918493
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Detection of relevant pharmacogenetic information through exome sequencing in oncology.
Verdez Simon et al. Pharmacogenomics 2022
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Implementing Pharmacogenetic Testing in Gastrointestinal Cancers (IMPACT-GI): Study Protocol for a Pragmatic Implementation Trial for Establishing DPYD and UGT1A1 Screening to Guide Chemotherapy Dosing.
Varughese Lisa A et al. Frontiers in oncology 2022 12859846
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Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy.
Diasio Robert B et al. Cancers 2022 14(13)
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Cost-effectiveness of DPYD Genotyping Prior to Fluoropyrimidine-based Adjuvant Chemotherapy for Colon Cancer.
Brooks Gabriel A et al. Clinical colorectal cancer 2022
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Dihydropyrimidine Dehydrogenase Deficiency and Implementation of Upfront DPYD Genotyping.
White Cassandra et al. Clinical pharmacology and therapeutics 2022
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Xeroderma pigmentosum: an updated review.
Leung Alexander Kc et al. Drugs in context 2022 11
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Comutation of PIK3CA and TP53 in Residual Disease After Preoperative Anti-HER2 Therapy in ERBB2 (HER2)-Amplified Early Breast Cancer.
Holmes Frankie Ann et al. JCO precision oncology 2022 31-26
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Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing.
Reizine Natalie M et al. Cancer 2022
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Real-World Evaluation of Universal Germline Screening for Cancer Treatment-Relevant Pharmacogenes.
Hutchcraft Megan L et al. Cancers 2021 13(18)
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DPYD Genotyping in Patients Who Have Planned Cancer Treatment With Fluoropyrimidines: A Health Technology Assessment.
et al. Ontario health technology assessment series 2021 21(14) 1-186
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[New recommendation on pharmacogenetic screening prior to 5-fluorouracil based cancer treatment - Swedish experience indicates less adverse effects and healthcare cost savings].
Schultz Alice et al. Lakartidningen 2021 118
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Association of emergence of new mutations in circulating tumuor DNA during chemotherapy with clinical outcome in metastatic colorectal cancer.
Jia Ning et al. BMC cancer 2021 21(1) 845
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All You Need to Know About DPYD Genetic Testing for Patients Treated With Fluorouracil and Capecitabine: A Practitioner-Friendly Guide.
Innocenti Federico et al. JCO oncology practice 2020 Nov OP2000553
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Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance).
Lenz Heinz-Josef et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 37(22) 1876-1885
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Mismatch Repair Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy.
Cercek Andrea et al. Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Mar
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The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.
Angus Lindsay et al. Nature genetics 2019 Sep
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Association of Prognostic Value of Primary Tumor Location in Stage III Colon Cancer With RAS and BRAF Mutational Status.
Taieb Julien et al. JAMA oncology 2018 4(7) e173695
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Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial.
Sparano Joseph A, et al. JAMA oncology 2019 9 0.
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Negative Hyperselection of Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer Who Received Panitumumab-Based Maintenance Therapy.
Morano Federica et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 Sep JCO1901254
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Local Coverage Determination (LCD): Genetic Testing for Lynch Syndrome (L34912)
The U.S. Centers for Medicare & Medicaid Services
Local Coverage Determination (LCD): Cetuximab (Erbitux) (L33278)
The U.S. Centers for Medicare & Medicaid Services
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen Ezra E W et al. Journal for immunotherapy of cancer 2019 Jul 7(1) 184
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Three Biomarkers Predict Gastric Cancer Patients' Susceptibility To Fluorouracil-based Chemotherapy.
Pan Jiaomeng et al. Journal of Cancer 2019 10(13) 2953-2960
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Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update.
Sohal Davendra P S et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 Aug 36(24) 2545-2556
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DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.
Henricks Linda M et al. The Lancet. Oncology 2018 19(11) 1459-1467
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Page last reviewed:
Feb 1, 2024
Page last updated:
Apr 25, 2024
Content source:
Public Health Genomics Branch in the Division of Blood Disorders and Public Health Genomics
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National Center on Birth Defects and Developmental Disabilities
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