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Public Health Genomics and Precision Health Knowledge Base (v9.0)
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Precision Health Database|Search|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Rare Diseases
Last data update: Apr 25, 2024
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Cytogenetic Heterogeneity in Chronic Lymphocytic Leukemia.
Pina J Trivedi et al. Journal of the Association of Genetic Technologists 2023 49(1) 4-9
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A survival prediction model and nomogram based on immune-related gene expression in chronic lymphocytic leukemia cells.
Huang Han-Ying et al. Frontiers in medicine 2023 91026812
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The inherited genetic contribution and polygenic risk score for risk of CLL and MBL: a narrative review.
Kleinstern Geffen et al. Leukemia & lymphoma 2022 1-11
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Rare Germline ATM Variants Influence the Development of Chronic Lymphocytic Leukemia.
Lampson Benjamin L et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2022 JCO2200269
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Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.
Robbe Pauline et al. Nature genetics 2022
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Molecular map of chronic lymphocytic leukemia and its impact on outcome.
Knisbacher Binyamin A et al. Nature genetics 2022
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Landscape of TP53 Alterations in Chronic Lymphocytic Leukemia via Data Mining Mutation Databases.
Soussi Thierry et al. Frontiers in oncology 2022 12808886
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Evaluation of a Prognostic Epigenetic Classification System in Chronic Lymphocytic Leukemia Patients.
Grimm Christina et al. Biomarker insights 2022 1711772719211067972
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Up to 6.5 years (median 4 years) of follow-up of first-line ibrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and high-risk genomic features: integrated analysis of two phase 3 studies.
Burger Jan A et al. Leukemia & lymphoma 2022 1-12
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Molecular characterization of Novel ATM fusions in chronic lymphocytic leukemia and T-cell prolymphocytic leukemia.
Kanagal-Shamanna Rashmi et al. Leukemia & lymphoma 2021 1-11
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Cellular and humoral Immune response to mRNA COVID-19 vaccination in subjects with chronic lymphocytic leukemia
ZL Lyski et al, MEDRXIV, November 5, 2021
Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients.
Pacholewska Alicja et al. International journal of molecular sciences 2021 22(17)
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An overview of genetic predisposition to familial hematological malignancies.
Hamadou Walid Sabri et al. Bulletin du cancer 2021
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Comparison Between Venetoclax-based and Bruton Tyrosine Kinase Inhibitor-based Therapy as Upfront Treatment of Chronic Lymphocytic Leukemia (CLL): A Systematic Review and Network Meta-analysis.
Molica Stefano et al. Clinical lymphoma, myeloma & leukemia 2020 Oct
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[Fluorescence in Situ Hybridization for Detecting Molecular Cytogenetic Abnormalities of Chronic Lymphocytic Leukemia].
Zhang Hai-Ying et al. Zhongguo shi yan xue ye xue za zhi 2020 Oct 28(5) 1474-1479
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Venetoclax Plus Rituximab in Relapsed Chronic Lymphocytic Leukemia: 4-Year Results and Evaluation of Impact of Genomic Complexity and Gene Mutations From the MURANO Phase III Study.
Kater Arnon P et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2020 Sep JCO2000948
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Prognostic and Predictive Molecular Biomarkers in Chronic Lymphocytic Leukemia.
Lee Jimmy et al. The Journal of molecular diagnostics : JMD 2020 Jun
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Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencing.
Davi Frédéric et al. Leukemia 2020 Jun
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Comprehensive Genomic Analysis of Noonan Syndrome and Acute Myeloid Leukemia in Adults: A Review and Future Directions.
Alhumaid Muhned S et al. Acta haematologica 2020 Jun 1-11
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Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.
Tausch Eugen et al. Blood 2020 Mar
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Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study.
Leeksma Alexander C et al. Haematologica 2020 Jan
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Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.
Tausch Eugen et al. Haematologica 2020 Jan
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An update on: molecular genetics of high-risk chronic lymphocytic leukemia.
Moia Riccardo et al. Expert review of hematology 2019 Nov 1-8
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Undetectable MRD Using Next Generation Sequencing is Associated With Improved PFS After Treatment with FCR for CLL.
Thompson Philip A et al. Blood 2019 Sep
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Noncoding RNAs in Extracellular Fluids as Cancer Biomarkers: The New Frontier of Liquid Biopsies.
Pardini Barbara et al. Cancers 2019 Aug 11(8)
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Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics.
Speedy Helen E et al. Nature communications 2019 Aug 10(1) 3615
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Local Coverage Determination (LCD): Flow Cytometry (L33661)
The U.S. Centers for Medicare & Medicaid Services
iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL.
Hallek Michael et al. Blood 2018 131(25) 2745-2760
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Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction.
Kurtz David M, et al. Cell 2019 7 0. (3) 699-713.e19
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Impact of gene mutations and chromosomal aberrations on progression-free survival in chronic lymphocytic leukemia patients treated with front-line chemoimmunotherapy: Clinical practice experience.
Spunarova Michaela et al. Leukemia research 2019 Apr 8175-81
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Page last reviewed:
Feb 1, 2024
Page last updated:
Apr 25, 2024
Content source:
Public Health Genomics Branch in the Division of Blood Disorders and Public Health Genomics
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National Center on Birth Defects and Developmental Disabilities
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