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Public Health Genomics and Precision Health Knowledge Base (v9.0)
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Precision Health Database|Search|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Pharmacogenomics
Last data update: Apr 25, 2024
. (Total: 63675 Documents since 2012)
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Real-World Cost Effectiveness of a Policy of KRAS Testing to Inform Cetuximab or Panitumumab for Third-Line Therapy of Metastatic Colorectal Cancer in British Columbia, Canada.
Reka E Pataky et al. Pharmacoecon Open 2023
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A Cost-effectiveness Analysis of Adding Cetuximab to the First-line Treatment of Metastatic Colorectal Carcinoma in Iran; Considering Genetic Screening for Precision Medicine.
Yousefi Nazila et al. Journal of gastrointestinal cancer 2023
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A study of gene variation in All-RAS wild-type metastatic colorectal cancer and its correlation with cetuximab.
Tao Huimin et al. Journal of gastrointestinal oncology 2023 13(6) 3009-3024
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Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C
R Yaeger et al, NEJM, December 21, 2022
Mutation analysis of a 10-gene panel for colorectal cancer in Huizhou, Guangdong Province of China.
Li Jun et al. The Journal of international medical research 2021 49(11) 3000605211061040
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Cetuximab plus irinotecan administered biweekly with reduced infusion time to heavily pretreated patients with metastatic colorectal cancer and related RAS and BRAF mutation status.
Jensen Benny V et al. International journal of cancer 2020 Dec
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Cetuximab in Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Ovarian Cancer Without KRAS, NRAS, or BRAF Mutations: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.
Fisher Julie G et al. Targeted oncology 2020 Oct
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Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance).
Lenz Heinz-Josef et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 37(22) 1876-1885
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Comprehensive analysis of colorectal cancer-risk loci and survival outcome: A prognostic role for CDH1 variants.
Summers Matthew G et al. European journal of cancer (Oxford, England : 1990) 2020 12456-63
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Guideline-recommended incorporation of biomarker testing results in metastatic colorectal cancer therapy.
Freml Jared et al. Personalized medicine 2020 Apr
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Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives.
Martinelli E et al. Annals of oncology : official journal of the European Society for Medical Oncology 2020 Jan 31(1) 30-40
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Molecular genetics of cutaneous squamous cell carcinoma: perspective for treatment strategies.
Di Nardo Lucia et al. Journal of the European Academy of Dermatology and Venereology : JEADV 2019 Nov
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Precision treatment in colorectal cancer: Now and the future.
Yau Tung On et al. JGH open : an open access journal of gastroenterology and hepatology 2019 Oct 3(5) 361-369
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Association of Prognostic Value of Primary Tumor Location in Stage III Colon Cancer With RAS and BRAF Mutational Status.
Taieb Julien et al. JAMA oncology 2018 4(7) e173695
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Translational Genomics and Recent Advances in Oral Squamous Cell Carcinoma.
Yeeng Chai Annie Wai et al. Seminars in cancer biology 2019 Sep
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Local Coverage Determination (LCD): Cetuximab (Erbitux) (L33278)
The U.S. Centers for Medicare & Medicaid Services
Local Coverage Determination (LCD): Genomic Sequence Analysis Panels in the Treatment of Solid Organ Neoplasms (L37810)
The U.S. Centers for Medicare & Medicaid Services
Colorectal adenocarcinoma-derived EGFR mutants are oncogenic and sensitive to EGFR-targeted monoclonal antibodies, cetuximab and panitumumab.
Kim Nayoung et al. International journal of cancer 2019 Jun
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Treatment of stage IV non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Socinski Mark A et al. Chest 2013 May 143(5 Suppl) e341S-e368S
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Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy.
Madi Ayman et al. European journal of cancer (Oxford, England : 1990) 2018 Oct 10231-39
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Molecular genetics of head and neck squamous cell carcinoma.
Saada-Bouzid Esma et al. Current opinion in oncology 2019 Mar
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Economic Value of Pharmacogenetic Testing for Cancer Drugs with Clinically Relevant Drug-Gene Associations: A Systematic Literature Review.
Faruque Fahim et al. Journal of managed care & specialty pharmacy 2019 Feb 25(2) 260-271
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Rechallenge for Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer With Acquired Resistance to First-line Cetuximab and Irinotecan: A Phase 2 Single-Arm Clinical Trial.
Cremolini Chiara et al. JAMA oncology 2018 Nov
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A Pilot Prospective Study of Refractory Solid Tumor Patients for NGS-Based Targeted Anticancer Therapy.
Seol Young Mi et al. Translational oncology 2018 Nov 12(2) 301-307
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Future of Evidence Synthesis in Precision Oncology: Between Systematic Reviews and Biocuration
SM Boca et al, JCO Precision Oncology, September 2018
RAS-expanded Mutations and HER2 Expression in Metastatic Colorectal Cancer: A New Step of Precision Medicine.
Valentini Anna M et al. Applied immunohistochemistry & molecular morphology : AIMM 2018 Sep 26(8) 539-544
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Liquid Biopsy 'Weather Forecast' Can Predict When Tumors Will Return
V Forster, Forbes, August 30, 2018
Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation.
Cecchin Erika et al. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2018 Jul 3918-40
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Precision Medicine in Metastatic Colorectal Cancer: Relevant Carcinogenic Pathways and Targets-PART 1: Biologic Therapies Targeting the Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor.
Weinberg Benjamin A et al. Oncology (Williston Park, N.Y.) 2017 31(7) 539-48
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Molecular Testing for the Treatment of Advanced Colorectal Cancer: An Overview.
Lin Patrick S et al. Methods in molecular biology (Clifton, N.J.) 2018 1765281-297
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Page last reviewed:
Feb 1, 2024
Page last updated:
Apr 25, 2024
Content source:
Public Health Genomics Branch in the Division of Blood Disorders and Public Health Genomics
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National Center on Birth Defects and Developmental Disabilities
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