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Family Health History PHGKB

Specific PHGKB|Family Health History PHGKB|PHGKB

Last Posted: Mar 04, 2021
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A Proclamation on National Colorectal Cancer Awareness Month, 2021
The White House, March 1, 2021

People with increased risk for developing the disease include certain racial and ethnic minority populations, as well as individuals with inflammatory bowel disease, a family history of colorectal cancer, or other risk factors such as tobacco use.

Family history assessment significantly enhances delivery of precision medicine in the genomics era.
Bylstra Yasmin et al. Genome medicine 2021 Jan (1) 3

This study demonstrates that the collection and analysis of comprehensive family history and genomic data are complementary and in combination can prioritize individuals for genomic analysis. Thus, family history remains a critical component of health risk assessment, providing important actionable data when implementing genomics screening programs.

Family Health History PHGKB
CDC, November 2020

Family Health History PHGKB is an online, continuously updated, searchable database of information and publications relevant to the role of family health history in healthcare and disease prevention.

Happy Thanksgiving 2020: Family and Family Health History Are As Important As Ever
RF Green et al, November 23, 2020

This Thanksgiving might not look the same as the ones before it, but some things haven’t changed. Even if you can’t see your loved ones in person, Thanksgiving is still a great time to talk to your family members about your family health history.


news Latest News and Publications
Familial Hypercholesterolemia: A Narrative Review on Diagnosis and Management Strategies for Children and Adolescents. External Web Site Icon
Tada Hayato et al. Vascular health and risk management 2021 1759-67
Risk-adapted starting age of breast cancer screening in women with a family history of ovarian or other cancers: A nationwide cohort study. External Web Site Icon
Mukama Trasias et al. Cancer 2021
The Value of Family History in Colorectal Screening Decisions for Oldest Old Geriatric Populations. External Web Site Icon
Miller David R et al. Cureus 2021 13(1) e12815
Polygenic risk score is a predictor of adenomatous polyps at screening colonoscopy. External Web Site Icon
Northcutt Michael J et al. BMC gastroenterology 2021 Feb 21(1) 65
Room for improvement: One third of Lynch syndrome patients presenting for genetic testing in a highly specialised centre in Stockholm already have cancer. External Web Site Icon
Bernstedt Sophie Walton et al. Hereditary cancer in clinical practice 2021 Feb 19(1) 18
Familial Colorectal Cancer and Genetic Susceptibility: Colorectal Risk Variants in First-Degree Relatives of Patients With Colorectal Cancer. External Web Site Icon
Gargallo-Puyuelo Carla J et al. Clinical and translational gastroenterology 2021 Feb 12(2) e00301
Family history of prostate cancer and prostate tumor aggressiveness in black and non-black men;results from an equal access biopsy study. External Web Site Icon
Jenkins Kimberly R et al. Cancer causes & control : CCC 2021 Feb
First-degree family history of prostate cancer is associated the risk of breast cancer and ovarian cancer. External Web Site Icon
Zheng QiongFei et al. Medicine 2021 Jan 100(4) e23816
Genetic predisposition to prostate cancer: an update. External Web Site Icon
Ni Raghallaigh Holly et al. Familial cancer 2021 Jan
Germline pathogenic variants in the Ataxia Telangiectasia Mutated (ATM) gene are associated with high and moderate risks for multiple cancers. External Web Site Icon
Hall Michael J et al. Cancer prevention research (Philadelphia, Pa.) 2021 Jan
Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later. External Web Site Icon
Isgut Monica et al. Genome medicine 2021 Jan 13(1) 13
LDL-cholesterol lowering and clinical outcomes in hypercholesterolemic subjects with and without a familial hypercholesterolemia phenotype: Analysis from the secondary prevention 4S trial. External Web Site Icon
Vallejo-Vaz Antonio J et al. Atherosclerosis 2021 Jan 3201-9
Targeting lung cancer screening to individuals at greatest risk: the role of genetic factors. External Web Site Icon
Lebrett Mikey B et al. Journal of medical genetics 2021 Jan
A streamlined model for use in clinical breast cancer risk assessment maintains predictive power and is further improved with inclusion of a polygenic risk score. External Web Site Icon
Allman Richard et al. PloS one 2021 16(1) e0245375
Assessing Lung Cancer Absolute Risk Trajectory based on a Polygenic Risk Model. External Web Site Icon
Hung Rayjean J et al. Cancer research 2021 Jan
Correlates of Coronary Artery Calcification Prevalence and Severity in Patients With Heterozygous Familial Hypercholesterolemia. External Web Site Icon
Drouin-Chartier Jean-Philippe et al. CJC open 2021 Jan 3(1) 62-70
Cost-Effectiveness of Coronary Artery Calcium Scoring in People With a Family History of Coronary Disease. External Web Site Icon
Venkataraman Prasanna et al. JACC. Cardiovascular imaging 2021 Jan
Family History of Pulmonary Fibrosis Predicts Worse Survival in Patients with Interstitial Lung Disease. External Web Site Icon
Cutting Claire et al. Chest 2021 Jan
Influence of lived experience on risk perception among women who received a breast cancer polygenic risk score: 'Another piece of the pie'. External Web Site Icon
Willis Amanda M et al. Journal of genetic counseling 2021 Jan
Adopted individuals' interest in elective genomic testing. External Web Site Icon
Edgar Jessica et al. Journal of medical genetics 2020 Dec

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Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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