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Family Health History PHGKB

Specific PHGKB|Family Health History PHGKB|PHGKB

Last Posted: Jan 27, 2023
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Risk of Sudden Infant Death Syndrome Among Siblings of Children Who Died of Sudden Infant Death Syndrome in Denmark.
Charlotte Glinge et al. JAMA network open 2023 1 (1) e2252724

Is a family history of sudden infant death syndrome (SIDS) associated with increased risk of subsequent SIDS compared with the general population? In this cohort study of more than 2.6 million consecutive births in Denmark between 1978 and 2016, a total of 1540 infants died of SIDS. A higher rate of SIDS was observed among siblings of children who died of SIDS compared with the general population. These findings suggest that any sibling of a child who died of SIDS should be investigated with great care to exclude genetic and environmental factors.

Increasing Use and Impact of Family Health History in Medically Underserved Populations: Work in Progress
G Wood et al, CDC Blog Post, December 20, 2022

Despite years of public health efforts, family health history remains underutilized in clinical care, especially among people who are medically underserved. To address these issues, CDC’s Office of Genomics and Precision Public Health hosted a webinar on November 14, 2022, in conjunction with National Family Health History Day (Thanksgiving). The speakers called for better informed, systematic, and tailored efforts to address inequities in clinical use of FHH

Calculating variant penetrance from family history of disease and average family size in population-scale data.
Spargo Thomas P et al. Genome medicine 2022 12 (1) 141

We present a method for penetrance estimation in autosomal dominant phenotypes. It examines the distribution of a variant among people affected (cases) and unaffected (controls) by a phenotype within population-scale data and can be operated using cases only by considering family disease history. It is validated through simulation studies and candidate variant-disease case studies.

Implementation-effectiveness trial of systematic family health history based risk assessment and impact on clinical disease prevention and surveillance activities.
Wu R Ryanne et al. BMC health services research 2022 12 (1) 1486

19 primary care clinics at four geographically and culturally diverse U.S. healthcare systems. Participants: any English or Spanish-speaking adult with an upcoming appointment at an enrolling clinic. A personal and family health history based HRA with integrated guideline-based clinical decision support (CDS) was completed by each participant prior to their appointment. Risk reports were provided to patients and providers to discuss at their clinical encounter. Systematic health risk assessment revealed that almost half the population were at increased disease risk based on guidelines. Risk identification resulted in shared discussions between participants and providers but variable clinical action uptake depending upon the recommendation.

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Can Automated Alerts in the Electronic Health Record Encourage Referrals for Genetic Counseling and Testing Among Patients at High Risk for Hereditary Cancer Syndromes? External Web Site Icon
Zorn Kristin K et al. JCO oncology practice 2022 OP2100641
Do current family history-based genetic testing guidelines contribute to breast cancer health inequities? External Web Site Icon
Jakuboski Samantha H et al. NPJ breast cancer 2022 8(1) 36


Disclaimer: Articles listed in the Public Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.